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Using real genotype data, simulate a complex trait as a function of latent expression, fit eQTL weights in independent data, and perform GWAS/TWAS on complex trait.

Shell 26 4 Updated Jun 18, 2023

Python command line tool for Multi-Trait Analysis of GWAS (MTAG)

Python 169 54 Updated Jul 6, 2023

R package for performing 2-sample MR using MR-Base database

R 430 176 Updated Sep 26, 2024

Estimate local SNP heritability and genetic covariance from GWAS summary association statistics.

HTML 39 11 Updated May 2, 2018

Repo for the R package coloc

R 146 44 Updated Aug 16, 2024

Materials for GCB535 at Penn.

Jupyter Notebook 20 8 Updated Apr 19, 2019

Data objects for various sets of instruments

R 43 19 Updated Jun 22, 2020

LD Score Regression (LDSC)

Python 641 342 Updated Aug 16, 2024