This is an implementation of the Poission Margin Test (PMT) for normalisation-free significance analysis of NGS data. Unlike other methods that have a step to normalise differing library sizes, the PMT incorporates the library size as part of the model.

• Adam Kowalczyk, Justin Bedo, Thomas Conway, and Bryan Beresford-Smith. "The poisson margin test for normalization-free significance analysis of NGS data." Journal of Computational Biology 18.3 (2011): 391-400.