Term merge: [term labels and ID] Merge GO:0039724 (symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IKBKE activity) into GO:0085034 (symbiont-mediated suppression of host NF-kappaB cascade) #28253
Labels
Term to be merged: Provide GO ID and term label
GO:0039724 (symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IKBKE activity)
Which term do you propose this term merge into? Provide GO ID and term label
GO:0085034 (symbiont-mediated suppression of host NF-kappaB cascade) AND its name should be changed to "symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via suppression of host NF-kappaB cascade"--this should be a child of...
GO:0039537 (symbiont-mediated suppression of cytoplasmic pattern recognition receptor signaling pathway)
Reason for merge
The GO:0039724 term is TOO specific "A process in which a symbiont interferes with, inhibits or disrupts a cytoplasmic pattern recognition receptor signaling pathway by reducing the activity of host I-kappa-B kinase epsilon (IKBKE/IKK-epsilon/IKK-E)" and I can't see that it has any annotations. There are a LOT of things that a symbiont can do to suppress NFkappaB signaling and this term hits just a tiny fraction. A better term is
GO:0039723 (symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity) This term at least names an entire component of the NFkappaB signaling pathway. In fact, GO:0039723 should be a child of the renovated GO:0085034 while GO:0039724 should simply be obsoleted/disappear.
Reference(s)
PMID:nnnnnn
Any other information
@pgaudet
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