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The term 'glutamine catabolic process' appears to have the correct asserted parent and LD (noting that 'CHEBI:32678 glutaminate' is the conjugate base of glutamine):
id: GO:0006543
name: glutamine catabolic process
def: "The chemical reactions and pathways resulting in the breakdown of glutamine, 2-amino-4-carbamoylbutanoic acid." [GOC:ai]
is_a: GO:0009065 ! glutamine family amino acid catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: has_primary_input CHEBI:32678 ! glutaminate
But that term has three child terms that appear to have LD errors, resulting in them being incorrectly classified as children of 'glutamate catabolic process (GO:0006538)' (in addition to being children of 'glutamine catabolic process'):
id: GO:0019460
name: glutamine catabolic process to fumarate
def: "The chemical reactions and pathways resulting in the breakdown of glutamine into other compounds, including fumarate." [GOC:go_curators]
is_a: GO:0006543 ! glutamine catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: has_primary_input CHEBI:14321 ! glutamate(1-)
intersection_of: has_primary_output CHEBI:29806 ! fumarate(2-)
relationship: has_part GO:0019550 ! glutamate catabolic process to aspartate
id: GO:0019462
name: glutamine catabolic process to fumarate, using glutaminase
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glutamine into fumarate, beginning with conversion of glutamine into glutamate catalyzed by the enzyme glutaminase (EC:3.5.1.2)." [GOC:bf, GOC:jl]
xref: MetaCyc:GLUTAMINDEG-PWY
intersection_of: GO:0009056 ! catabolic process
intersection_of: has_part GO:0004359 ! glutaminase activity
intersection_of: has_primary_input CHEBI:14321 ! glutamate(1-)
intersection_of: has_primary_output CHEBI:29806 ! fumarate(2-)
id: GO:0019461
name: glutamine catabolic process to fumarate, using glutamate synthase (NADPH)
def: "The chemical reactions and pathways resulting in the breakdown of glutamine into fumarate, beginning with the conversion of glutamine to glutamate catalyzed by the enzyme glutamate synthase (NADPH) (EC:1.4.1.13)." [GOC:bf, GOC:jl]
xref: MetaCyc:GLUTAMINEFUM-PWY
intersection_of: GO:0009056 ! catabolic process
intersection_of: has_part GO:0004355 ! glutamate synthase (NADPH) activity
intersection_of: has_primary_input CHEBI:14321 ! glutamate(1-)
intersection_of: has_primary_output CHEBI:29806 ! fumarate(2-)
For those 3 terms, it looks like we need to change:
intersection_of: has_primary_input CHEBI:14321 ! glutamate(1-)
to
intersection_of: has_primary_input CHEBI:32678 ! glutaminate
On the other hand, all three terms (GO:0019460, GO:0019462 and GO:0019461) could just be obsoleted because:
none of them have any annotations
GO:0019462 and GO:0019461 are defined by single-step MetaCyc pathways
these MetaCyc 'pathways' just describe the conversion of L-glutamine -> L-glutamate, so not really "glutamine catabolic process to fumarate" anyway.
the definition of 'glutamine catabolic process to fumarate GO:0019460' (= "The chemical reactions and pathways resulting in the breakdown of glutamine into other compounds, including fumarate.") isn't really any different from its parent 'glutamine catabolic process' (= "The chemical reactions and pathways resulting in the breakdown of glutamine, 2-amino-4-carbamoylbutanoic acid.")
The text was updated successfully, but these errors were encountered:
The term 'glutamine catabolic process' appears to have the correct asserted parent and LD (noting that 'CHEBI:32678 glutaminate' is the conjugate base of glutamine):
id: GO:0006543
name: glutamine catabolic process
def: "The chemical reactions and pathways resulting in the breakdown of glutamine, 2-amino-4-carbamoylbutanoic acid." [GOC:ai]
is_a: GO:0009065 ! glutamine family amino acid catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: has_primary_input CHEBI:32678 ! glutaminate
But that term has three child terms that appear to have LD errors, resulting in them being incorrectly classified as children of 'glutamate catabolic process (GO:0006538)' (in addition to being children of 'glutamine catabolic process'):
id: GO:0019460
name: glutamine catabolic process to fumarate
def: "The chemical reactions and pathways resulting in the breakdown of glutamine into other compounds, including fumarate." [GOC:go_curators]
is_a: GO:0006543 ! glutamine catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: has_primary_input CHEBI:14321 ! glutamate(1-)
intersection_of: has_primary_output CHEBI:29806 ! fumarate(2-)
relationship: has_part GO:0019550 ! glutamate catabolic process to aspartate
id: GO:0019462
name: glutamine catabolic process to fumarate, using glutaminase
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glutamine into fumarate, beginning with conversion of glutamine into glutamate catalyzed by the enzyme glutaminase (EC:3.5.1.2)." [GOC:bf, GOC:jl]
xref: MetaCyc:GLUTAMINDEG-PWY
intersection_of: GO:0009056 ! catabolic process
intersection_of: has_part GO:0004359 ! glutaminase activity
intersection_of: has_primary_input CHEBI:14321 ! glutamate(1-)
intersection_of: has_primary_output CHEBI:29806 ! fumarate(2-)
id: GO:0019461
name: glutamine catabolic process to fumarate, using glutamate synthase (NADPH)
def: "The chemical reactions and pathways resulting in the breakdown of glutamine into fumarate, beginning with the conversion of glutamine to glutamate catalyzed by the enzyme glutamate synthase (NADPH) (EC:1.4.1.13)." [GOC:bf, GOC:jl]
xref: MetaCyc:GLUTAMINEFUM-PWY
intersection_of: GO:0009056 ! catabolic process
intersection_of: has_part GO:0004355 ! glutamate synthase (NADPH) activity
intersection_of: has_primary_input CHEBI:14321 ! glutamate(1-)
intersection_of: has_primary_output CHEBI:29806 ! fumarate(2-)
For those 3 terms, it looks like we need to change:
intersection_of: has_primary_input CHEBI:14321 ! glutamate(1-)
to
intersection_of: has_primary_input CHEBI:32678 ! glutaminate
On the other hand, all three terms (GO:0019460, GO:0019462 and GO:0019461) could just be obsoleted because:
The text was updated successfully, but these errors were encountered: