Skip to content
New issue

Have a question about this project? Sign up for a free GitHub account to open an issue and contact its maintainers and the community.

By clicking “Sign up for GitHub”, you agree to our terms of service and privacy statement. We’ll occasionally send you account related emails.

Already on GitHub? Sign in to your account

Obsoletion request: GO:0101030 tRNA-guanine transglycosylation #27782

Open
1 of 12 tasks
sjm41 opened this issue Apr 30, 2024 · 0 comments
Open
1 of 12 tasks

Obsoletion request: GO:0101030 tRNA-guanine transglycosylation #27782

sjm41 opened this issue Apr 30, 2024 · 0 comments

Comments

@sjm41
Copy link
Contributor

sjm41 commented Apr 30, 2024

Please provide as much information as you can:

  • GO term ID and Label
    GO:0101030 tRNA-guanine transglycosylation
    The modification of a tRNA anticodon loop by replacing guanine with queuonine. Reaction is tRNA guanine + queuine = tRNA queuine + guanine. PMID:24911101

  • Reason for deprecation Put an x in the appropriate box:

  • The reason for obsoletion is that this term represents a molecular function.
  • "Replace by" term (ID and label)

  • "Consider" term(s) (ID and label)
    MF: GO:0008479 tRNA-guanosine(34) queuine transglycosylase activity
    Catalysis of the reaction: guanosine34 in tRNA + queuine = guanine + queuosine34 in tRNA.

BP: GO:0002099 tRNA wobble guanine modification
The process in which a guanine in t position 34 of a tRNA is post-transcriptionally modified.

  • Are there annotations to this term?
    How many EXP: 14

  • Are there mappings and cross references to this term? (InterPro, Keywords; check QuickGO cross-references section)
    IPR004803

  • Is this term in a subset? (check the AmiGO page for that term)
    No

  • Any other information
    I think we need to retain one BP for this process (i.e. GO:0002099 tRNA wobble guanine modification) as the process appears to be multi-step in bacteria and archaea (but not eukaryotes.)
    E.g. IPR004803 entry says: In eukaryotes, queuine is directly exchanged into tRNA while in eubacteria, a queuine precursor (preQ1) is incorporated and ultimately modified to queuine. Archaea contain a closely related enzyme [IPR004804] that catalyses a base exchange of guanine for an archaeosine precursor. This precursor is then subsequently converted to the archaeal-specific modified base archaeosine.


Checklist for ontology editor

Check term usage and metadata in Protégé

  • check term usage in the ontology
  • check internal mappings: RHEA, EC, MetaCyc
  • check subset usage
  • check taxon constraints

Check annotations

Notification

Sign up for free to join this conversation on GitHub. Already have an account? Sign in to comment
Projects
None yet
Development

No branches or pull requests

1 participant