-
Notifications
You must be signed in to change notification settings - Fork 39
New issue
Have a question about this project? Sign up for a free GitHub account to open an issue and contact its maintainers and the community.
By clicking “Sign up for GitHub”, you agree to our terms of service and privacy statement. We’ll occasionally send you account related emails.
Already on GitHub? Sign in to your account
Obsoletion request: GO:0042960 antimonite secondary active transmembrane transporter activity #27767
Comments
Hi Pascale, No this is not right. ArsB proteins in some bacteria (including P0AB93 in E. coli) are pmf-dependent efflux pumps. They are secondary transporters which belong to transport class 2.A.45 [https://tcdb.org/search/result.php?tc=2.A.45] Amanda |
Thanks @amandamackie So is the UniProt description incorrect then ?
|
Oh or maybe they mean that it's the 'pore'/channel part of the complex, but not that's is a 'channel' in terms of mechanism... ? |
Can I move the term as a child of proton motive force dependent protein transmembrane transporter activity? |
I think this is a case where the biology is not amenable to discrete categorisation. In some bacteria ArsB forms a complex with an ATPase (ArsA protein) and the complex functions to export arsenite. So these ArsAB protein complexes will be primary active transporters - Transport Classification DB has a nice explanantion (see [https://tcdb.org/search/result.php?tc=3.A.4]. BUT in other bacteria including E. coli K-12 there is no ArsA ATPase and the same ArsB protein functions as a pmf dependent arsenite exporter. Re: GO:0009977: proton motive force dependent protein transmembrane transporter activity. My understanding is that this term refers to the pmf-dependent transport of proteins so it would not be an appropriate parent for pmf-dependent arsenite transport. |
GO:0042960 antimonite secondary active transmembrane transporter activity has a single annotation by EcoCyc to P0AB93. It seems this term has the same meaning as ATPase-coupled antimonite transmembrane transporter activity
Likewise for GO:0008490 arsenite secondary active transmembrane transporter activity ; should it be merged into ATPase-coupled arsenite transmembrane transporter activity; the same gene transports antimonite and arsenite.
@amandamackie Is this right? It certainly seems to be a primary active transporter.
Thanks, Pascale
The text was updated successfully, but these errors were encountered: