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Normalized using --perGroup with the plotProfile tool #1151

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aaperez9201 opened this issue Jul 23, 2022 · 0 comments
Open
4 tasks

Normalized using --perGroup with the plotProfile tool #1151

aaperez9201 opened this issue Jul 23, 2022 · 0 comments

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@aaperez9201
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Welcome to deepTools GitHub repository! Before opening the issue please check
that the following requirements are met :

  • Search whether this issue (or a similar issue) has been solved before
    using the search tab above. Link the previous issue if appropriate below.

  • Paste your deepTools version (deeptools --version) and your python
    version (python --version) below.
    deeptools 3.1.3
    Python 3.7.11

  • Paste the full deepTools command that produces the issue below
    (ignore if you simply spotted the issue in the code/documentation).

  • Paste the output printed on screen from the command that produces the issue
    below (ignore if you simply spotted the issue in the code/documentation).

This isn't an issue, per se, but rather a request to add functionality to the plotProfile tool. Currently, the plot profile tool allows you to plot the signal of a bigwig at specific genomic coordinates. the --perGroup argument allows the profile of the signal to be plotted on the same plot. This is great for understanding how much signal there is at the chosen coordinates. It is also great if you want to know where the signal is relative to each other (eg. relative positioning of the factors of interest on a promoter), but only when the signal is of similar strength. If the signal of the factors are varying by ~20 fold, it makes understanding the positioning of the factors more challenging (see attachment for an example). Is there a way to make the plot on a relative scale such that the apex of the signal are all at the same point on the y axis?
image

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