BioSynth is an innovative tool designed to simulate and visualize protein synthesis from DNA sequences. It integrates modern bioinformatics methods to provide a detailed understanding of the relationship between DNA sequences and their corresponding protein structures.

• 🧬 DNA Transcription and Translation: Converts DNA sequences into RNA sequences and subsequently translates them into protein sequences following the central dogma of molecular biology. Learn more about Transcription and Translation.
• 🧪 Mutation Simulation: Introduces random mutations in the DNA sequence to study their effects on the resulting protein. Read about Mutation Types.
• 🖼️ 3D Visualization: Generates and visualizes 3D structures of proteins and DNA-protein complexes using py3Dmol. Py3Dmol Documentation.
• ⚡ Asynchronous Processing: Utilizes Python's asyncio for efficient handling of multiple synthesis tasks concurrently. Asyncio Official Documentation.

BioSynth performs several key steps to transform a DNA sequence into a visualized 3D modeled protein. In this section, we'll delve into each of these steps in detail:

Transcription is the first step in protein synthesis, where the DNA sequence is transcribed into a messenger RNA (mRNA) sequence. This process involves replacing thymine (T) in the DNA with uracil (U) in the RNA.

• Process: The DNA sequence is unwound, and enzymes copy one of the strands to form mRNA.
• Example:

  dna_sequence = "ATGCGTACGTTAG"
  rna_sequence = dna_sequence.replace("T", "U")
  print("RNA Sequence:", rna_sequence)

2. 🔄 Translation: The RNA sequence is then translated into a protein sequence based on codon tables. A Guide to Translation.
3. 🧬 Protein Mutation: A random base in the DNA sequence is mutated to simulate real-world genetic variations. Understanding Genetic Mutations.
4. 🏗️ Structure Generation: 3D structures of the synthesized protein and DNA-protein complexes are generated and saved as PDB files. PDB File Format.
5. 🔍 Visualization: The generated structures are visualized in an interactive 3D viewer. 3D Molecular Visualization Tools.