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Magnushhoie authored Jul 3, 2023
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# Overview

DiscoTope-3.0 is a structure-based B-cell epitope prediction tool, exploiting inverse folding latent representations from the [ESM-IF1](https://github.com/facebookresearch/esm) model. The tool accepts input protein structures in the [PDB](https://en.wikipedia.org/wiki/Protein_Data_Bank_(file_format)) format (solved or predicted), and outputs per-residue epitope propensity scores in both a PDB and CSV format.
[DiscoTope-3.0](https://services.healthtech.dtu.dk/services/DiscoTope-3.0/) is a structure-based B-cell epitope prediction tool, exploiting inverse folding latent representations from the [ESM-IF1](https://github.com/facebookresearch/esm) model. The tool accepts input protein structures in the [PDB](https://en.wikipedia.org/wiki/Protein_Data_Bank_(file_format)) format (solved or predicted), and outputs per-residue epitope propensity scores in both a PDB and CSV format.

DiscoTope-3.0 accepts both experimental and AlphaFold2 modeled structures, with similar performance for both. It has been trained and validated only on single chain structures.

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