This gene encodes a transmembrane protein which is a member of the immunoglobulin superfamily. This protein is found on thymocytes and mature T cells. It plays an essential role in T-cell interactions and also in T-cell/B-cell interaction during early lymphoid development.[5]
CD7 can be aberrantly expressed in refractory anaemia with excess blasts (RAEB) and may confer a worse prognosis.[8] Also, a lack of CD7 expression could insinuate mycosis fungoides (MF) or Sezary syndrome (SS).[9]
^Ogata K, Kakumoto K, Matsuda A, Tohyama K, Tamura H, Ueda Y, Kurokawa M, Takeuchi J, Shibayama H, Emi N, Motoji T, Miyazaki Y, Tamaki H, Mitani K, Naoe T, Sugiyama H, Takaku F (October 2012). "Differences in blast immunophenotypes among disease types in myelodysplastic syndromes: a multicenter validation study". Leukemia Research. 36 (10): 1229–36. doi:10.1016/j.leukres.2012.05.006. PMID22682984.
^Stevens SR, Baron ED, Masten S, Cooper KD (October 2002). "Circulating CD4+CD7- lymphocyte burden and rapidity of response: predictors of outcome in the treatment of Sézary syndrome and erythrodermic mycosis fungoides with extracorporeal photopheresis". Archives of Dermatology. 138 (10): 1347–50. doi:10.1001/archderm.138.10.1347. PMID12374541. S2CID40541131.
Yoshikawa K, Seto M, Ueda R, Obata Y, Notake K, Yokochi T, Takahashi T (1991). "Molecular cloning of the gene coding for the human T cell differentiation antigen CD7". Immunogenetics. 33 (5–6): 352–60. doi:10.1007/BF00216694. PMID1711009. S2CID20322510.
Osada S, Utsumi KR, Ueda R, Akao Y, Tsuge I, Nishida K, Okada J, Matsuoka H, Takahashi T (1988). "Assignment of a gene coding for a human T-cell antigen with a molecular weight of 40,000 daltons to chromosome 17". Cytogenetics and Cell Genetics. 47 (1–2): 8–10. doi:10.1159/000132494. PMID3258561.
Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID8125298.
Lee DM, Schanberg LE, Fleenor DE, Seldin MF, Haynes BF, Kaufman RE (1996). "The mouse CD7 gene: identification of a new element common to the human CD7 and mouse Thy-1 promoters". Immunogenetics. 44 (2): 108–14. doi:10.1007/s002510050097. PMID8662072. S2CID29837811.
Leta E, Hou Z, Lederman L, Jung LK (October 1996). "Interaction between the extracellular domain of CD7 and concanavalin A: a clue to the identity of the ligand for CD7". Cellular Immunology. 173 (1): 15–21. doi:10.1006/cimm.1996.0247. PMID8871597.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID9373149.
Slentz-Kesler KA, Hale LP, Kaufman RE (February 1998). "Identification and characterization of K12 (SECTM1), a novel human gene that encodes a Golgi-associated protein with transmembrane and secreted isoforms". Genomics. 47 (3): 327–40. doi:10.1006/geno.1997.5151. PMID9480746.
