Vav is a family of proteins involved in cell signalling. They act as guanine nucleotide exchange factors (GEFs) for small G proteins of the Rho family.[1][2] GEF activity is mediated via module of tandem DH-PH domains. Vav proteins also appear to exhibit GEF-independent functions. Although it was originally thought that Vav proteins would only be present in multicellular organisms,[1] Vav family proteins have been observed in Choanoflagellates.[2]
Function
editSome functions of the Vav protein are important for the immune system. Specifically the ability of Vav to change the cytoskeletal structure of lymphocytes, which is particularly used to "aim" cytokines towards bound pathogens or cells.[3]
In humans there are three Vav proteins:
References
edit- ^ a b Bustelo, X. R. (March 2000). "Regulatory and Signaling Properties of the Vav Family". Molecular and Cellular Biology. 20 (5): 1461–1477. doi:10.1128/MCB.20.5.1461-1477.2000. PMC 85310. PMID 10669724.
- ^ a b Bustelo, Xosé R (November 2014). "Vav family exchange factors: an integrated regulatory and functional view". Small GTPases. 5 (2): e973757. doi:10.4161/21541248.2014.973757. PMC 4601183. PMID 25483299.
- ^ "Vav (Protein)". sciencedirect.com.
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