PBX1

PBX1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1B72, 1PUF
Dynodwyr
Cyfenwau	PBX1, PBX homeobox 1, CAKUHED
Dynodwyr allanol	OMIM: 176310 HomoloGene: 20574 GeneCards: PBX1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • sequence-specific DNA binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • protein heterodimerization activity • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • DNA binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • transcription factor binding • GO:0001948, GO:0016582 protein binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cydrannau o'r gell • cytoplasm • cnewyllyn cell • transcription regulator complex • nucleoplasm • RNA polymerase II transcription regulator complex Prosesau biolegol • anterior/posterior pattern specification • proximal/distal pattern formation • positive regulation of G2/M transition of mitotic cell cycle • embryonic organ development • embryonic hemopoiesis • negative regulation of DNA-binding transcription factor activity • transcription, DNA-templated • sex differentiation • multicellular organism development • embryonic limb morphogenesis • somatic stem cell population maintenance • regulation of cell population proliferation • adrenal gland development • spleen development • thymus development • positive regulation of cell population proliferation • urogenital system development • GO:0009373 regulation of transcription, DNA-templated • regulation of ossification • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • transcription by RNA polymerase II • negative regulation of neuron differentiation • embryonic skeletal system development • branching involved in ureteric bud morphogenesis • steroid biosynthetic process • cell differentiation • animal organ morphogenesis • positive regulation of transcription of Notch receptor target Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5087	n/a
Ensembl	ENSG00000185630	n/a
UniProt	P40424	n/a
RefSeq (mRNA)	NM_001204961 NM_001204963 NM_002585 NM_001353130 NM_001353131	n/a
RefSeq (protein)	NP_001191890 NP_001191892 NP_002576 NP_001340059 NP_001340060	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PBX1 yw PBX1 a elwir hefyd yn Pre-B-cell leukemia transcription factor 1 a PBX homeobox 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1q23.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PBX1.

• CAKUHED

Llyfryddiaeth

• "The PBX1 lupus susceptibility gene regulates CD44 expression. ". Mol Immunol. 2017. PMID 28257976.
• "Ovarian Cancer Chemoresistance Relies on the Stem Cell Reprogramming Factor PBX1. ". Cancer Res. 2016. PMID 27590741.
• "Targeted Exome Sequencing Identifies PBX1as Involved in Monogenic Congenital Anomalies of the Kidney and Urinary Tract. ". J Am Soc Nephrol. 2017. PMID 28566479.
• "PBX1haploinsufficiency leads to syndromic congenital anomalies of the kidney and urinary tract (CAKUT) in humans. ". J Med Genet. 2017. PMID 28270404.
• "Overexpression of lipid metabolism genes and PBX1 in the contralateral breasts of women with estrogen receptor-negative breast cancer.". Int J Cancer. 2017. PMID 28263391.