PAK3

PAK3
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1EES
Dynodwyr
Cyfenwau	PAK3, CDKN1A, MRX30, MRX47, OPHN3, PAK3beta, bPAK, hPAK-3, beta-PAK, ARA, p21 (RAC1) activated kinase 3, XLID30
Dynodwyr allanol	OMIM: 300142 HomoloGene: 55664 GeneCards: PAK3
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • nucleotide binding • protein kinase activity • SH3 domain binding • metal ion binding • kinase activity • GO:0001948, GO:0016582 protein binding • catalytic activity • GTPase binding • ATP binding • MAP kinase kinase activity • protein serine/threonine kinase activity Cydrannau o'r gell • cytoplasm • cytosol • endosome • Cellbilen • GO:0097483, GO:0097481 postsynaptic density • glutamatergic synapse Prosesau biolegol • regulation of neuron projection development • phosphorylation • ephrin receptor signaling pathway • dendrite development • T cell costimulation • synapse organization • GO:1904579 cellular response to organic cyclic compound • stimulatory C-type lectin receptor signaling pathway • multicellular organism development • protein phosphorylation • regulation of actin filament polymerization • positive regulation of neuron apoptotic process • dendritic spine development • positive regulation of DNA biosynthetic process • metabolaeth • T cell receptor signaling pathway • positive regulation of dendritic spine morphogenesis • MAPK cascade • regulation of actin cytoskeleton organization • positive regulation of fibroblast migration • dendritic spine morphogenesis • Rho protein signal transduction • regulation of mitotic cell cycle • axonogenesis • cell migration • stress-activated protein kinase signaling cascade • regulation of axonogenesis • regulation of apoptotic process • GO:0072468 signal transduction • activation of protein kinase activity • regulation of MAPK cascade Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5063	n/a
Ensembl	ENSG00000077264	n/a
UniProt	O75914	n/a
RefSeq (mRNA)	NM_001128166 NM_001128167 NM_001128168 NM_001128172 NM_001128173 NM_002578 NM_001324325 NM_001324326 NM_001324327 NM_001324328 NM_001324329 NM_001324330 NM_001324331 NM_001324332 NM_001324333 NM_001324334	n/a
RefSeq (protein)	NP_001121638 NP_001121639 NP_001121640 NP_001121644 NP_001121645 NP_001311254 NP_001311255 NP_001311256 NP_001311257 NP_001311258 NP_001311259 NP_001311260 NP_001311261 NP_001311262 NP_001311263 NP_002569	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PAK3 yw PAK3 a elwir hefyd yn P21 (RAC1) activated kinase 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom X dynol, band Xq23.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PAK3.

• ARA
• bPAK
• MRX30
• MRX47
• OPHN3
• PAK-3
• PAK3beta
• beta-PAK

Llyfryddiaeth

• "A novel long non-coding RNA-ARA: adriamycin resistance-associated. ". Biochem Pharmacol. 2014. PMID 24184505.
• "PAK signalling in neuronal physiology. ". Cell Signal. 2009. PMID 19036346.
• "Sequence analysis of P21-activated kinase 3 (PAK3) in chronic schizophrenia with cognitive impairment. ". Schizophr Res. 2008. PMID 18805672.
• "UnPAKing the class differences among p21-activated kinases. ". Trends Biochem Sci. 2008. PMID 18639460.
• "A novel splice mutation in PAK3 gene underlying mental retardation with neuropsychiatric features.". Eur J Hum Genet. 2008. PMID 18523455.