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| Original file line number | Diff line number | Diff line change |
|---|---|---|
| @@ -0,0 +1,31 @@ | ||
| library(NonCompart) | ||
| library(dplyr) | ||
| library(tidyr) | ||
| library(tibble) | ||
|
|
||
| head(Indometh) | ||
|
|
||
| ncaIndometh <- tabNCA(Indometh, colSubj="Subject", | ||
| colTime="time", colConc="conc", | ||
| dose=25, adm="Infusion", dur=0.5, concUnit="mg/L") | ||
| write.csv(ncaIndometh, 'data/ncaIndometh.csv', row.names = FALSE) | ||
|
|
||
| ncaIndometh %>% colnames() | ||
|
|
||
| ncaIndomethLong <- ncaIndometh %>% | ||
| as.tibble() %>% | ||
| arrange(ID) %>% | ||
| gather(key = 'PKparameter', value = 'PKparameterValue', b0:VSSP) | ||
|
|
||
| write.csv(ncaIndomethLong, 'data/ncaIndomethLong.csv', row.names = FALSE) | ||
|
|
||
| ncaIndomethStar <- ncaIndomethLong %>% | ||
| group_by(PKparameter) %>% | ||
| mutate(Ranking = min_rank(desc(PKparameterValue))) %>% | ||
| mutate(Star = ifelse(Ranking == 1, | ||
| yes = '*', | ||
| no = ifelse(Ranking == 6, | ||
| yes = '**', | ||
| no = ' '))) | ||
|
|
||
| write.csv(ncaIndomethStar, 'data/ncaIndomethStar.csv', row.names = FALSE) |
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| Original file line number | Diff line number | Diff line change |
|---|---|---|
| @@ -0,0 +1,7 @@ | ||
| "ID","b0","CMAX","CMAXD","TMAX","TLAG","CLST","CLSTP","TLST","LAMZHL","LAMZ","LAMZLL","LAMZUL","LAMZNPT","CORRXY","R2","R2ADJ","AUCLST","AUCALL","AUCIFO","AUCIFOD","AUCIFP","AUCIFPD","AUCPEO","AUCPEP","AUMCLST","AUMCIFO","AUMCIFP","AUMCPEO","AUMCPEP","MRTIVLST","MRTIVIFO","MRTIVIFP","VZO","VZP","CLO","CLP","VSSO","VSSP" | ||
| 1,-1.72421059639646,1.5,0.06,0.25,0,0.05,0.0502485064135143,8,4.37812701206528,0.158320482400297,5,8,3,-0.998532286621828,0.997066727426216,0.994133454852432,1.74125,1.74125,2.05706510643443,0.0822826042573772,2.0586347480231,0.0823453899209241,15.3527034922993,15.4172442842464,3.27125,7.79255448051925,7.81502594373644,58.0208260567461,58.1415337127341,1.62867910983489,3.53819049340947,3.54621783380523,76.7635174614967,76.7049877929306,12.1532371152478,12.1439706698857,43.0004680253208,43.0651653627562 | ||
| 3,-0.175286858431038,2.03,0.0812,0.25,0,0.08,0.0747559092002026,8,2.293063170278,0.302280019819912,0.75,8,9,-0.973482979595454,0.947669111562043,0.94019327035662,2.9325,2.9325,3.19715526913642,0.127886210765457,3.17980681586146,0.127192272634459,8.2778359778536,7.77741637095222,6.39875,9.39152229661219,9.19534267578028,31.8667432402495,30.4131425481974,1.93201193520887,2.68746205799662,2.64179286927502,25.8682374307925,26.0093698751079,7.81945132328614,7.86211284135105,21.0144787456829,20.7700736417167 | ||
| 6,0.155579544657487,2.72,0.1088,0.25,0,0.08,0.0399725765960521,8,1.64294680807057,0.421892648718165,0.5,8,10,-0.935855785859431,0.875826051926574,0.860304308417395,2.93375,2.93375,3.12337169699582,0.124934867879833,3.02849584759299,0.121139833903719,6.07105767072826,3.12847870233298,5.00625,6.97267842561125,5.9887901357925,28.2019090166038,16.4063210350329,1.45643374520665,1.98242031434102,1.72748005517403,18.9720552210259,19.5664063261934,8.00417062882588,8.2549229908536,15.8676304540362,14.2602148236972 | ||
| 2,0.0643586275963175,1.85,0.074,0.25,0,0.07,0.0344498520872912,8,1.61544094217238,0.429076150334429,0.5,8,10,-0.931191674546507,0.867117934744728,0.850507676587818,2.4775,2.4775,2.64064120452848,0.105625648181139,2.55778843379069,0.102311537351628,6.17809054288414,3.13897868682219,4.381875,6.06721967358498,5.21130178173009,27.7778746156581,15.915923054733,1.51866801210898,2.04763122047032,1.78742487567935,22.0646090817291,22.7793335575756,9.46739752342239,9.7740687500684,19.3857387455631,17.4704136204725 | ||
| 4,-0.982357129866236,2.05,0.082,0.25,0,0.06,0.0495714902818329,8,2.74244612209262,0.252747784168332,1,8,8,-0.935544879811905,0.875244222142273,0.854451592499318,1.95375,1.95375,2.19114080521489,0.0876456322085957,2.14988026656177,0.085995210662471,10.83411913328,9.12284603065077,3.7075,6.54586634839538,6.05253416426272,43.3612022813628,38.7446662938147,1.64763275751759,2.73742387199229,2.56528895278541,45.1421630553333,46.0085322167232,11.409581684801,11.6285545706141,31.2328612734204,29.8306025768587 | ||
| 5,-0.0499189799474626,2.31,0.0924,0.25,0,0.09,0.0562424678832525,8,1.9606985693831,0.353520521401732,0.75,8,9,-0.950764854539454,0.903953808627429,0.890232924145633,2.8725,2.8725,3.12708210924544,0.125083284369817,3.0315925122543,0.121263700490172,8.14120321601879,5.24781980464785,5.5325,8.28929076671746,7.25526351286615,33.2572573975366,23.7450164258139,1.6760226283725,2.40080687910611,2.14321857523362,22.61445337783,23.3267671305837,7.99467334934562,8.24649087862073,19.1936667733153,17.6740324315546 |
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| Original file line number | Diff line number | Diff line change |
|---|---|---|
| @@ -0,0 +1,229 @@ | ||
| "ID","PKparameter","PKparameterValue" | ||
| 1,"b0",-1.72421059639646 | ||
| 2,"b0",0.0643586275963175 | ||
| 3,"b0",-0.175286858431038 | ||
| 4,"b0",-0.982357129866236 | ||
| 5,"b0",-0.0499189799474626 | ||
| 6,"b0",0.155579544657487 | ||
| 1,"CMAX",1.5 | ||
| 2,"CMAX",1.85 | ||
| 3,"CMAX",2.03 | ||
| 4,"CMAX",2.05 | ||
| 5,"CMAX",2.31 | ||
| 6,"CMAX",2.72 | ||
| 1,"CMAXD",0.06 | ||
| 2,"CMAXD",0.074 | ||
| 3,"CMAXD",0.0812 | ||
| 4,"CMAXD",0.082 | ||
| 5,"CMAXD",0.0924 | ||
| 6,"CMAXD",0.1088 | ||
| 1,"TMAX",0.25 | ||
| 2,"TMAX",0.25 | ||
| 3,"TMAX",0.25 | ||
| 4,"TMAX",0.25 | ||
| 5,"TMAX",0.25 | ||
| 6,"TMAX",0.25 | ||
| 1,"TLAG",0 | ||
| 2,"TLAG",0 | ||
| 3,"TLAG",0 | ||
| 4,"TLAG",0 | ||
| 5,"TLAG",0 | ||
| 6,"TLAG",0 | ||
| 1,"CLST",0.05 | ||
| 2,"CLST",0.07 | ||
| 3,"CLST",0.08 | ||
| 4,"CLST",0.06 | ||
| 5,"CLST",0.09 | ||
| 6,"CLST",0.08 | ||
| 1,"CLSTP",0.0502485064135143 | ||
| 2,"CLSTP",0.0344498520872912 | ||
| 3,"CLSTP",0.0747559092002026 | ||
| 4,"CLSTP",0.0495714902818329 | ||
| 5,"CLSTP",0.0562424678832525 | ||
| 6,"CLSTP",0.0399725765960521 | ||
| 1,"TLST",8 | ||
| 2,"TLST",8 | ||
| 3,"TLST",8 | ||
| 4,"TLST",8 | ||
| 5,"TLST",8 | ||
| 6,"TLST",8 | ||
| 1,"LAMZHL",4.37812701206528 | ||
| 2,"LAMZHL",1.61544094217238 | ||
| 3,"LAMZHL",2.293063170278 | ||
| 4,"LAMZHL",2.74244612209262 | ||
| 5,"LAMZHL",1.9606985693831 | ||
| 6,"LAMZHL",1.64294680807057 | ||
| 1,"LAMZ",0.158320482400297 | ||
| 2,"LAMZ",0.429076150334429 | ||
| 3,"LAMZ",0.302280019819912 | ||
| 4,"LAMZ",0.252747784168332 | ||
| 5,"LAMZ",0.353520521401732 | ||
| 6,"LAMZ",0.421892648718165 | ||
| 1,"LAMZLL",5 | ||
| 2,"LAMZLL",0.5 | ||
| 3,"LAMZLL",0.75 | ||
| 4,"LAMZLL",1 | ||
| 5,"LAMZLL",0.75 | ||
| 6,"LAMZLL",0.5 | ||
| 1,"LAMZUL",8 | ||
| 2,"LAMZUL",8 | ||
| 3,"LAMZUL",8 | ||
| 4,"LAMZUL",8 | ||
| 5,"LAMZUL",8 | ||
| 6,"LAMZUL",8 | ||
| 1,"LAMZNPT",3 | ||
| 2,"LAMZNPT",10 | ||
| 3,"LAMZNPT",9 | ||
| 4,"LAMZNPT",8 | ||
| 5,"LAMZNPT",9 | ||
| 6,"LAMZNPT",10 | ||
| 1,"CORRXY",-0.998532286621828 | ||
| 2,"CORRXY",-0.931191674546507 | ||
| 3,"CORRXY",-0.973482979595454 | ||
| 4,"CORRXY",-0.935544879811905 | ||
| 5,"CORRXY",-0.950764854539454 | ||
| 6,"CORRXY",-0.935855785859431 | ||
| 1,"R2",0.997066727426216 | ||
| 2,"R2",0.867117934744728 | ||
| 3,"R2",0.947669111562043 | ||
| 4,"R2",0.875244222142273 | ||
| 5,"R2",0.903953808627429 | ||
| 6,"R2",0.875826051926574 | ||
| 1,"R2ADJ",0.994133454852432 | ||
| 2,"R2ADJ",0.850507676587818 | ||
| 3,"R2ADJ",0.94019327035662 | ||
| 4,"R2ADJ",0.854451592499318 | ||
| 5,"R2ADJ",0.890232924145633 | ||
| 6,"R2ADJ",0.860304308417395 | ||
| 1,"AUCLST",1.74125 | ||
| 2,"AUCLST",2.4775 | ||
| 3,"AUCLST",2.9325 | ||
| 4,"AUCLST",1.95375 | ||
| 5,"AUCLST",2.8725 | ||
| 6,"AUCLST",2.93375 | ||
| 1,"AUCALL",1.74125 | ||
| 2,"AUCALL",2.4775 | ||
| 3,"AUCALL",2.9325 | ||
| 4,"AUCALL",1.95375 | ||
| 5,"AUCALL",2.8725 | ||
| 6,"AUCALL",2.93375 | ||
| 1,"AUCIFO",2.05706510643443 | ||
| 2,"AUCIFO",2.64064120452848 | ||
| 3,"AUCIFO",3.19715526913642 | ||
| 4,"AUCIFO",2.19114080521489 | ||
| 5,"AUCIFO",3.12708210924544 | ||
| 6,"AUCIFO",3.12337169699582 | ||
| 1,"AUCIFOD",0.0822826042573772 | ||
| 2,"AUCIFOD",0.105625648181139 | ||
| 3,"AUCIFOD",0.127886210765457 | ||
| 4,"AUCIFOD",0.0876456322085957 | ||
| 5,"AUCIFOD",0.125083284369817 | ||
| 6,"AUCIFOD",0.124934867879833 | ||
| 1,"AUCIFP",2.0586347480231 | ||
| 2,"AUCIFP",2.55778843379069 | ||
| 3,"AUCIFP",3.17980681586146 | ||
| 4,"AUCIFP",2.14988026656177 | ||
| 5,"AUCIFP",3.0315925122543 | ||
| 6,"AUCIFP",3.02849584759299 | ||
| 1,"AUCIFPD",0.0823453899209241 | ||
| 2,"AUCIFPD",0.102311537351628 | ||
| 3,"AUCIFPD",0.127192272634459 | ||
| 4,"AUCIFPD",0.085995210662471 | ||
| 5,"AUCIFPD",0.121263700490172 | ||
| 6,"AUCIFPD",0.121139833903719 | ||
| 1,"AUCPEO",15.3527034922993 | ||
| 2,"AUCPEO",6.17809054288414 | ||
| 3,"AUCPEO",8.2778359778536 | ||
| 4,"AUCPEO",10.83411913328 | ||
| 5,"AUCPEO",8.14120321601879 | ||
| 6,"AUCPEO",6.07105767072826 | ||
| 1,"AUCPEP",15.4172442842464 | ||
| 2,"AUCPEP",3.13897868682219 | ||
| 3,"AUCPEP",7.77741637095222 | ||
| 4,"AUCPEP",9.12284603065077 | ||
| 5,"AUCPEP",5.24781980464785 | ||
| 6,"AUCPEP",3.12847870233298 | ||
| 1,"AUMCLST",3.27125 | ||
| 2,"AUMCLST",4.381875 | ||
| 3,"AUMCLST",6.39875 | ||
| 4,"AUMCLST",3.7075 | ||
| 5,"AUMCLST",5.5325 | ||
| 6,"AUMCLST",5.00625 | ||
| 1,"AUMCIFO",7.79255448051925 | ||
| 2,"AUMCIFO",6.06721967358498 | ||
| 3,"AUMCIFO",9.39152229661219 | ||
| 4,"AUMCIFO",6.54586634839538 | ||
| 5,"AUMCIFO",8.28929076671746 | ||
| 6,"AUMCIFO",6.97267842561125 | ||
| 1,"AUMCIFP",7.81502594373644 | ||
| 2,"AUMCIFP",5.21130178173009 | ||
| 3,"AUMCIFP",9.19534267578028 | ||
| 4,"AUMCIFP",6.05253416426272 | ||
| 5,"AUMCIFP",7.25526351286615 | ||
| 6,"AUMCIFP",5.9887901357925 | ||
| 1,"AUMCPEO",58.0208260567461 | ||
| 2,"AUMCPEO",27.7778746156581 | ||
| 3,"AUMCPEO",31.8667432402495 | ||
| 4,"AUMCPEO",43.3612022813628 | ||
| 5,"AUMCPEO",33.2572573975366 | ||
| 6,"AUMCPEO",28.2019090166038 | ||
| 1,"AUMCPEP",58.1415337127341 | ||
| 2,"AUMCPEP",15.915923054733 | ||
| 3,"AUMCPEP",30.4131425481974 | ||
| 4,"AUMCPEP",38.7446662938147 | ||
| 5,"AUMCPEP",23.7450164258139 | ||
| 6,"AUMCPEP",16.4063210350329 | ||
| 1,"MRTIVLST",1.62867910983489 | ||
| 2,"MRTIVLST",1.51866801210898 | ||
| 3,"MRTIVLST",1.93201193520887 | ||
| 4,"MRTIVLST",1.64763275751759 | ||
| 5,"MRTIVLST",1.6760226283725 | ||
| 6,"MRTIVLST",1.45643374520665 | ||
| 1,"MRTIVIFO",3.53819049340947 | ||
| 2,"MRTIVIFO",2.04763122047032 | ||
| 3,"MRTIVIFO",2.68746205799662 | ||
| 4,"MRTIVIFO",2.73742387199229 | ||
| 5,"MRTIVIFO",2.40080687910611 | ||
| 6,"MRTIVIFO",1.98242031434102 | ||
| 1,"MRTIVIFP",3.54621783380523 | ||
| 2,"MRTIVIFP",1.78742487567935 | ||
| 3,"MRTIVIFP",2.64179286927502 | ||
| 4,"MRTIVIFP",2.56528895278541 | ||
| 5,"MRTIVIFP",2.14321857523362 | ||
| 6,"MRTIVIFP",1.72748005517403 | ||
| 1,"VZO",76.7635174614967 | ||
| 2,"VZO",22.0646090817291 | ||
| 3,"VZO",25.8682374307925 | ||
| 4,"VZO",45.1421630553333 | ||
| 5,"VZO",22.61445337783 | ||
| 6,"VZO",18.9720552210259 | ||
| 1,"VZP",76.7049877929306 | ||
| 2,"VZP",22.7793335575756 | ||
| 3,"VZP",26.0093698751079 | ||
| 4,"VZP",46.0085322167232 | ||
| 5,"VZP",23.3267671305837 | ||
| 6,"VZP",19.5664063261934 | ||
| 1,"CLO",12.1532371152478 | ||
| 2,"CLO",9.46739752342239 | ||
| 3,"CLO",7.81945132328614 | ||
| 4,"CLO",11.409581684801 | ||
| 5,"CLO",7.99467334934562 | ||
| 6,"CLO",8.00417062882588 | ||
| 1,"CLP",12.1439706698857 | ||
| 2,"CLP",9.7740687500684 | ||
| 3,"CLP",7.86211284135105 | ||
| 4,"CLP",11.6285545706141 | ||
| 5,"CLP",8.24649087862073 | ||
| 6,"CLP",8.2549229908536 | ||
| 1,"VSSO",43.0004680253208 | ||
| 2,"VSSO",19.3857387455631 | ||
| 3,"VSSO",21.0144787456829 | ||
| 4,"VSSO",31.2328612734204 | ||
| 5,"VSSO",19.1936667733153 | ||
| 6,"VSSO",15.8676304540362 | ||
| 1,"VSSP",43.0651653627562 | ||
| 2,"VSSP",17.4704136204725 | ||
| 3,"VSSP",20.7700736417167 | ||
| 4,"VSSP",29.8306025768587 | ||
| 5,"VSSP",17.6740324315546 | ||
| 6,"VSSP",14.2602148236972 |
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