Inflammatory agents such as lipopolysaccharide (LPS) and interferon-y (IFN-[gamma]) induce an inflammatory phenotype that promotes Th1 effector response and antimicrobial and tumouricidal properties.
The hormonal agents used in recurrent disease are GnRH analogues, Megestrol acetate, Leuprolide, and, more recently, Aromatase inhibitors.1-4,6-8 Aromatase inhibitors have consistently shown tumouricidal activity in vitro (in granulose cell lines) and in vivo experimental systems.7 To date, there are very few cases reported in literature of GCTs being treated with Aromatase inhibitors.6,7
in growing endobronchial exophytic tumours provides the first pathophysiological verification of the tumouricidal potential in endobronchial exophytic tumour growth and by mediastinal lymph node metastases.
NO is responsible for numerous functions such as neurotransmission, vascular homeostasis, immune regulation and host defense, as well as playing critical roles in the antipathogen and tumouricidal response of the immune system (4).