1H-NMR data were consistent with structures 5a~f, for example, the 1H-NMR spectrum for compound 5c exhibits three sharp singlets at 3.526, 3.734, 3.792 ppm, corresponding to the
methoxy proton at ester group and to the
methoxy proton at quinazoline ring and benzene ring, respectively.
It can be described as a three-dimensional, highly branched, polyphenolic substance consisting of an irregular array of variously bonded "hydroxyl" and "
methoxy"-substituted phenyl propane units.
A
methoxy signal at 5H 3.82 (3H, s) attached to aromatic ring was also observed.
The [sup.1]H NMR spectrum of 3 displayed resonances for an aromatic proton [[[delta].sub.5]H 7.05 (1H, s, H-4)], two meta-coupled protons [5h 6.84 ([[delta].sub.H,] d, J = 2.0 Hz, H-5) and 7.03 (2H, d, J = 2.0 Hz, H-7)], an aromatic methyl [[[delta].sub.H] 2.28 (3H, s, 3-C[H.sub.3])], a
methoxy group [[[delta].sub.H] 3.88 (3H, s, 6-OC[H.sub.3])], and a [beta]-anomeric proton of a sugar moiety [[[delta].sub.H] 5.12 (1H, d, J = 8.0 Hz, H-1').
University of Massachusetts scientists fabricated hydrogel microspheres by the electrostatic complexation of low
methoxy pectin and caseinate by decreasing the solution pH from 7 to 4.5.
The
methoxy groups at C-7 and C-ll of 11-O-methylWEL were located inside and outside the coumestan plane, respectively (Fig.
The contract has been signed for the commercialisation of Roche's prescription medicine Mircera (
methoxy polyethylene glycol-epoetin beta) in the US and Puerto Rico.
The signal due to methyl protons (ligand MPM) appeared as singlet at [delta] 2.37 and 2.44 ppm, whereas signal due to
methoxy protons appeared as singlet in the range [delta] 4.01-4.03 ppm.
Addition of a
methoxy group, in lieu of a hydroxyl group, to the terminal quinone of AQ resulted in an inhibitory anthraquinone, namely, 2MeO (Figure 2(c)).
The more fav ourabl e product was found to be the compound with the
methoxy group in ortho-position.