adenosis

Both foci of adenosis and sclerosing adenosis were present in 2 cases.

(1) Soon after, reports were published on laser treatment for diethylstilbestrol-associated vaginal adenosis, laser laparoscopy for adhesiolysis, laser hysteroscopy, and laser genital wart ablation.

(10) It is now well recognized by experts, through the benefit of immunostaining for basal cells, that most of the originally described GP 1 cancers were likely adenosis (atypical adenomatous hyperplasia) and that there are virtually no lesions that meet the stringent criteria set out for GP 1.

Proliferative lesions without atypia include ductal hyperplasia of the usual type, sclerosing adenosis, radial scar, and intraductal papilloma.

The cells that are constantly observed moderately positive to S100 are the SPs and stromal cells as particularly observed in the majority of the obtained specimens, in cases of adenoma, fibroadenoma, ductal papillomatosis, complex carcinoma, spindle cell carcinoma, chondrosarcoma, mucinous carcinoma, carcinosarcoma, and tubular adenosis. These SPs and irregularly-shaped cells in the stroma are identified as fibrocytes and fibroblasts as confirmed in the visualization of these cells in the hematoxylin and eosin staining based on its morphology.

Lesion pathology n (%) Fibroadenoma 40 (57.1) Sclerosing adenosis 14 (20) Fibrocystic change 7 (10) Papilloma 5 (7.1) Granulomatous mastitis 2 (2.8) Tubular adenoma 1 (1.4) Lipogranuloma 1 (1.4) Total 70 (100)

[37,38] Genomewide methylation profiling studies have identified multiple hypermethylated gene promoters including adenosis polyposis coli (APC) and others in HCC tumours compared with surrounding non-tumour tissue.

of cases (%) Malignant (n=48, 38.4%) DCIS 25 (52.1) IDC 21 (43.8) IDC+DCIS 7 DC mic 6 IDC 8 ILC 2 (4.2) Total 48 (100) Benign (n=77, 61.6%) Sclerosing adenosis 16 (20.8) Flat epithelial atypia 6 (7.8) Complex sclerosing adenosis 4 (5.2) LCIS 4 (5.2) ADH 2 (2.6) Intraductal papilloma 2 (2.6) Other benign changes- B2 43 (55.8) Total 77 (100) DCIS, ductal carcinoma in situ; IDC, invasive ductal carcinoma; DC mic, microinvasive ductal carcinoma; ILC, invasive lobular carcinoma; LCIS, lobular carcinoma in situ; ADH, atypical ductal hyperplasia.

Kurita, "The development of cervical and vaginal adenosis as a result of diethylstilbestrol exposure in utero," Differentiation, vol.

Accurate tissue diagnosis can be very challenging due to the presence of either a small focus of cancer or due to the presence of many benign mimickers of malignancy like adenosis. Although immunohistochemical stains for basal cells, such as high molecular weight cyto-keratin (HMWCK) or more recently p63 can aid in the diagnosis of focal prostate cancer, there are limitations in their use.

[2] These include all non-malignant conditions like fibroadenoma, fibrocystic disease, mastalgia, mammary duct ectasia, sclerosing adenosis, lactational adenoma, benign phyllodes tumour, intraductal papilloma, fibrous disease, blunt duct adenosis, calcification, breast abscess, lactational mastitis, puerperal mastitis, granulomatous lobular mastitis, fat necrosis, tuberculous mastitis, galactocele, gynaecomastia and lipoma.

Epithelial regions contained simple adenosis areas and microcysts (Figure 3).