Regulation of Organic Metabolism and Energy Balance: Multiple Choice Questions
Regulation of Organic Metabolism and Energy Balance: Multiple Choice Questions
Regulation of Organic Metabolism and Energy Balance: Multiple Choice Questions
Chapter 16
Regulation of Organic Metabolism and Energy Balance
16-1
Chapter 16 - Regulation of Organic Metabolism and Energy Balance
4. During the absorptive state of metabolism, the primary energy source for most of the
body's cells is ________, except for ________, which use ________ for energy.
A. Amino acids; brain cells; glucose
B. Fatty acids; brain cells; glucose
C. Glucose; liver cells; amino acids
D. Glucose; liver cells; ketones
E. Fatty acids; skeletal muscle cells; glucose
16-2
Chapter 16 - Regulation of Organic Metabolism and Energy Balance
7. The enzyme that converts chylomicron triacylglycerols into fatty acids is
A. Pancreatic lipase
B. Pancreatic amylase
C. Lipoprotein lipase
D. Pepsin
E. Hexokinase
8. Excess absorbed glucose is initially converted to triacylglycerides and very low density
lipoprotein by
A. Adipose cells
B. Liver cells
C. Intestinal mucosa cells
D. Muscle cells
E. Lymphoid cells
16-3
Chapter 16 - Regulation of Organic Metabolism and Energy Balance
11. Which of the following tissues is most dependent upon a constant blood supply of
glucose?
A. Liver
B. Brain
C. Adipose tissue
D. Skeletal muscle
E. Cardiac muscle
16-4
Chapter 16 - Regulation of Organic Metabolism and Energy Balance
13. Insulin
A. Increases the uptake and utilization of glucose by muscle and adipose tissue cells
B. Increases the uptake and utilization of glucose by most nerve cells
C. Decreases the uptake of amino acids by muscle cells
D. Both increases the uptake and utilization of glucose by muscle and adipose tissue cells and
increases the uptake and utilization of glucose by most nerve cells are correct
E. Both increases the uptake and utilization of glucose by muscle and adipose tissue cells and
decreases the uptake of amino acids by muscle cells are correct
14. As a result of binding to its receptor in skeletal muscle plasma membranes, insulin
A. Stimulates glycogen synthase
B. Stimulates glycogen phosphorylase
C. Inhibits the enzymes that mediate protein catabolism
D. Both stimulates glycogen synthase and inhibits the enzymes that mediate protein
catabolism are correct
E. Both stimulates glycogen phosphorylase and inhibits the enzymes that mediate protein
catabolism are correct
16-5
Chapter 16 - Regulation of Organic Metabolism and Energy Balance
16. When plasma glucose concentration increases, the secretion of insulin is ________ and
the secretion of glucagon is ________. However, an increase in sympathetic activity will
cause ________ secretion of insulin and ________ secretion of glucagon.
A. Decreased; increased; increased; decreased
B. Increased; decreased; decreased; increased
C. Increased; decreased; increased; decreased
D. Increased; increased; decreased; increased
E. Decreased; decreased; increased; unchanged
16-6
Chapter 16 - Regulation of Organic Metabolism and Energy Balance
21. Gluconeogenesis
A. Refers to the synthesis of glycogen in the muscle
B. Converts glucose to glycogen in the liver
C. Is stimulated by cortisol
D. Both refers to the synthesis of glycogen in the muscle and converts glucose to glycogen in
the liver are correct
E. Both refers to the synthesis of glycogen in the muscle and is stimulated by cortisol are
correct
16-7
Chapter 16 - Regulation of Organic Metabolism and Energy Balance
16-8
Chapter 16 - Regulation of Organic Metabolism and Energy Balance
25. Cortisol
A. Is required for cells to respond normally to hormones promoting gluconeogenesis and
lipolysis
B. Is permissive for insulin actions
C. In high amounts increases gluconeogenesis and inhibits glucose uptake
D. Both is required for cells to respond normally to hormones promoting gluconeogenesis and
lipolysis and is permissive for insulin actions are correct
E. Both is required for cells to respond normally to hormones promoting gluconeogenesis and
lipolysis and in high amounts increases gluconeogenesis and inhibits glucose uptake are
correct
27. During exercise,
A. Blood glucose levels fall dramatically
B. Epinephrine and glucagon stimulate glycogenolysis in liver cells
C. Decreased blood glucose and increased epinephrine stimulate insulin secretion
D. Epinephrine stimulates glucagon secretion and inhibits skeletal muscle uptake of glucose
E. Skeletal muscles increase their rate of utilization of fatty acids
16-9
Chapter 16 - Regulation of Organic Metabolism and Energy Balance
29. In Addison's disease, the adrenal cortices degenerate. What will be the metabolic
consequences to patients with this disease if they engage in strenuous physical activity or are
required to fast?
A. Hepatic gluconeogenesis will be impaired
B. Skeletal muscle glycogenolysis will be impaired
C. Lipolysis will be unaffected
D. Both hepatic gluconeogenesis will be impaired and skeletal muscle glycogenolysis will be
impaired are correct
E. Both hepatic gluconeogenesis will be impaired and lipolysis will be unaffected are correct
30. Which of the following is not a symptom that is associated with untreated IDDM?
A. Hypoglycemia
B. Metabolic acidosis
C. Dehydration
D. Glucosuria (glucose in urine)
E. Elevated glucagon secretion
16-10
Chapter 16 - Regulation of Organic Metabolism and Energy Balance
32. Compared to a normal person, a person with untreated type I diabetes mellitus would
have
A. Decreased glycogen stores in muscles
B. Increased appetite
C. Decreased blood pH
D. Decreased glycogen stores in muscles and decreased blood pH
E. All of the choices are correct.
16-11
Chapter 16 - Regulation of Organic Metabolism and Energy Balance
35. Cholesterol is a
A. Precursor of steroid hormones
B. Component of plasma membranes
C. Precursor of bile pigments
D. Both precursor of steroid hormones and component of plasma membranes are correct
E. All of the choices are correct.
36. Cholesterol or its derivatives are directly involved in each of the following except
A. Reproductive functions
B. Generation of energy
C. Absorption of fat-soluble vitamins
D. Regulation of metabolism
E. Plasma membrane functions
16-12
Chapter 16 - Regulation of Organic Metabolism and Energy Balance
37. Which of the following statements regarding plasma cholesterol concentration and the
development of atherosclerosis is correct?
A. It is preferable to have a high LDL:HDL ratio because LDL operate to remove cholesterol
from the peripheral tissues and carry it to the liver, which secretes it into the small intestine
B. It is preferable to have a low LDL:HDL ratio because HDL operate to remove cholesterol
from the peripheral tissues and carry it to the liver, which secretes it into the small intestine
C. It is preferable to have equal concentrations of LDL and HDL
D. Neither LDL nor HDL are involved in cholesterol regulation
E. Plasma cholesterol concentration has no relationship to atherosclerosis
16-13
Chapter 16 - Regulation of Organic Metabolism and Energy Balance
42. Which of the following contribute the most to differences in the basal metabolic rate
among individuals?
A. Sex, weight, age, and muscular activity
B. Age, height, and recent ingestion of food
C. Environmental temperature, body surface area, and emotional state
D. Sex, age, body surface area, and circulating levels of thyroid hormone
E. Environmental temperature, muscular activity, and emotional state
16-14
Chapter 16 - Regulation of Organic Metabolism and Energy Balance
44. The factor that increases metabolic rate to the greatest extent is increased
A. Skeletal muscle activity
B. Mental activity
C. Dietary caloric intake
D. Environmental temperature
E. Blood glucose levels
16-15
Chapter 16 - Regulation of Organic Metabolism and Energy Balance
46. If more calories are ingested in food than are expended by metabolism,
A. A person will gain weight
B. A person will lose weight
C. A person will stay the same weight because the excess energy is destroyed
D. One cannot predict what will happen because only the calories associated with the
consumption of fat affect whether one gains or loses weight
47. What factors affect the brain's control of food intake in a normal person?
A. Increased plasma insulin inhibits food intake
B. The hormone leptin decreases appetite
C. Increased body temperature decreases food intake
D. Decreased plasma glucose concentration stimulates appetite
E. All of the choices are correct.
48. Both IDDM and NIDDM subjects will experience increased appetite because
A. The brain needs insulin and functional insulin receptors to utilize glucose
B. High levels of glucose in plasma stimulate appetite
C. Specific appetite/satiety centers in the hypothalamus are not able to obtain enough glucose
D. Of all of these things
E. Of none of these things
16-16
Chapter 16 - Regulation of Organic Metabolism and Energy Balance
50. The major means of increasing heat production in response to a cold environment is
A. Vasoconstriction of blood vessels in the skin
B. Wearing warm clothing
C. Shivering thermogenesis and increased voluntary activity
D. Vasodilation of blood vessels in skin
E. Increasing food intake to elevate the metabolic rate
16-17
Chapter 16 - Regulation of Organic Metabolism and Energy Balance
53. Endogenous pyrogen
A. Is released by infection-fighting leukocytes
B. Acts on the temperature-integrating centers of the hypothalamus
C. Has actions that are enhanced by aspirin
D. Both is released by infection-fighting leukocytes and acts on the temperature-integrating
centers of the hypothalamus are correct
E. All of the choices are correct.
54. During the absorptive state, the body makes use of stored nutrients for energy.
FALSE
16-18
Chapter 16 - Regulation of Organic Metabolism and Energy Balance
55. The source of the triacylglycerol used for synthesis of very low density lipoproteins in the
liver is absorbed fatty acids and glycerol.
FALSE
56. Most of the glucose stored after a high-carbohydrate meal is stored in the form of
glycogen.
FALSE
57. Most of the triacylglycerols absorbed as chylomicrons are ultimately stored as fat in the
adipose tissue.
TRUE
58. During the absorptive state, there is net synthesis of fat, glycogen, and protein, but this
process is reversed during the postabsorptive state.
TRUE
16-19
Chapter 16 - Regulation of Organic Metabolism and Energy Balance
59. Most of the energy used by the body during fasting is provided by gluconeogenesis.
FALSE
16-20
Chapter 16 - Regulation of Organic Metabolism and Energy Balance
60. Fatty acids released by lipolysis of triacylglycerol in adipose tissue travel in the plasma as
VLDL.
FALSE
61. The major energy sources for non-nervous tissue during the postabsorptive period are
fatty acids and ketones.
TRUE
62. Insulin has no effect on the carrier-mediated transport of glucose in the liver; therefore,
insulin does not stimulate the uptake of glucose by that organ.
FALSE
63. The effects of insulin in any given cell on membrane transport and on enzyme activity are
mediated by the same receptor.
TRUE
16-21
Chapter 16 - Regulation of Organic Metabolism and Energy Balance
64. Insulin inhibits the enzymes in the liver that catalyze reactions leading to
gluconeogenesis.
TRUE
65. The metabolic events characteristic of the absorptive state can be attributed to the
presence of large amounts of insulin in the blood, whereas the events of the postabsorptive
state can be attributed largely to decreased insulin levels.
TRUE
67. The chemoreceptors for the reflexes that stimulate sympathetic activity and epinephrine
secretion in response to hypoglycemia are located in the carotid and aortic bodies.
FALSE
16-22
Chapter 16 - Regulation of Organic Metabolism and Energy Balance
68. Pituitary growth hormone has effects on protein metabolism similar to those of insulin,
but its effects on carbohydrate and lipid metabolism are similar to those of elevated cortisol.
TRUE
69. During stress, elevated levels of plasma cortisol stimulate the catabolism of muscle
protein and the conversion of alpha-keto acids to glucose in the liver.
TRUE
70. During exercise, glucose uptake by muscle cells is increased because of increased insulin
secretion.
FALSE
71. The primary fuel source for most cells in untreated insulin-dependent diabetes is alpha-
keto acids.
FALSE
16-23
Chapter 16 - Regulation of Organic Metabolism and Energy Balance
72. Metabolic acidosis caused by excessive blood levels of ketones is one of the most serious
consequences of untreated insulin-dependent diabetes.
TRUE
73. One serious consequence of insulin lack is the decreased ability of the brain to take up
glucose efficiently, a condition that can lead to brain dysfunction and death.
FALSE
74. The excretion of glucose in the urine of a diabetic patient is a result of the inability of the
kidney tubules to reabsorb glucose in the absence of insulin.
FALSE
16-24
Chapter 16 - Regulation of Organic Metabolism and Energy Balance
16-25
Chapter 16 - Regulation of Organic Metabolism and Energy Balance
77. All other things being equal, a person who is hypothyroid will have a higher BMR than a
person whose thyroid function is normal.
FALSE
78. The calorigenic effect of thyroid hormones refers to their effect in increasing the rate at
which the body synthesizes protein and fat.
FALSE
79. When total-body energy balance is positive in an adult, energy is being stored as fat.
TRUE
80. Insulin is a satiety signal that suppresses appetite, whereas glucagon stimulates appetite.
FALSE
16-26
Chapter 16 - Regulation of Organic Metabolism and Energy Balance
16-27
Chapter 16 - Regulation of Organic Metabolism and Energy Balance
82. In response to cold stimuli, human beings increase their rate of heat production primarily
by increasing basal metabolic rate.
FALSE
83. The body's most effective mechanism for reducing heat loss is vasoconstriction of blood
vessels in the skin.
TRUE
85. The reason high humidity plays such a significant role in increasing the discomfort felt on
very hot days is that it decreases the cooling properties of conduction.
FALSE
16-28
Chapter 16 - Regulation of Organic Metabolism and Energy Balance
86. Receptors for the regulation of body temperature are heat and cold receptors in the skin,
the CNS, and internal organs.
TRUE
16-29
Chapter 16 - Regulation of Organic Metabolism and Energy Balance
87. The integrating centers for temperature-regulating reflexes are located in the brain stem.
FALSE
88. Fever differs from other forms of hyperthermia in that it results from resetting the
hypothalamic "thermostat" to a higher level.
TRUE
16-30