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Fetal iodine syndrome

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Disease definition

Fetal iodine syndrome refers to symptoms and signs that may be observed in a fetus or newborn when the mother was exposed during pregnancy to inappropriate (insufficient or excessive) amounts of iodine. Iodine deficiency is associated with goiter and hypothyroidism. When severe iodine deficiency occurs during pregnancy, it is associated with congenital hypothyroidism that is manifested by increased neonatal morbi-mortality and severe mental dysfunction, hyperactivity, attention disorders and a substantial decrease of IQ of an irreversible nature. Excessive iodine ingestion during the third trimester of pregnancy can result in hypothyroidism and fetal goiter due to a prolonged inhibition of thyroid hormone synthesis, an increase in thyrotropin (TSH).

ORPHA:1910

Classification level: Disorder

Prevalence: Unknown

Inheritance: Not applicable

Age of onset: Antenatal, Neonatal

ICD-10: P72.2

ICD-11: 5A00.03

OMIM: 228355

UMLS: C4273860

GARD: 2304

A summary on this disease is available in Español (2016) Deutsch (2005) Italiano (2016) Nederlands (2016)
Detailed information
Guidelines
Anesthesia guidelines
English (2017) - Orphananesthesia
Español (2017) - Orphananesthesia
Čeština (2017) - Orphananesthesia
Disease review articles
Review article
English (2010) - Orphanet J Rare Dis

Logo ERN: produced/endorsed by ERN(s) Logo FSMR: produced/endorsed by FSMR(s)

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