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maeB malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)) [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946947, updated on 3-Dec-2024

Summary

Official Symbol
maeB
Official Full Name
malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+))
Primary source
ECOCYC:G7293
Locus tag
b2463
See related
ASAP:ABE-0008111
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2458; ypfF
Summary
Acetyl-CoA and cAMP are allosteric inhibitors. [More information is available at EcoGene: EG14193]. There are two malic enzymes in Escherichia coli, one NAD-linked (encoded by the maeA gene) and the other NADP-linked (encoded by the maeB gene) . [More information is available at EcoCyc: G7293].
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Genomic context

Sequence:
NC_000913.3 (2576098..2578377, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative ethanolamine utilization acetate kinase EutQ Neighboring gene putative ethanolamine utilization acetate kinase EutP Neighboring gene putative ethanolamine catabolic microcompartment shell protein EutS Neighboring gene transaldolase A Neighboring gene transketolase 2

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables NAD binding IEA
Inferred from Electronic Annotation
more info
 
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables malate dehydrogenase (decarboxylating) (NADP+) activity IDA
Inferred from Direct Assay
more info
PubMed 
enables malate dehydrogenase (decarboxylating) (NADP+) activity IEA
Inferred from Electronic Annotation
more info
 
enables malate dehydrogenase (decarboxylating) (NADP+) activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables malic enzyme activity IEA
Inferred from Electronic Annotation
more info
 
enables malolactic enzyme activity IDA
Inferred from Direct Assay
more info
PubMed 
enables manganese ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables oxaloacetate decarboxylase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in malate metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytosol HDA PubMed 

General protein information

Preferred Names
malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+))
NP_416958.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2576098..2578377 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416958.1 malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)) [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416958.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6C9QAP0
    Conserved Domains (1) summary
    PRK07232
    Location:3756
    PRK07232; bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed