KEGG   Varanus komodoensis (Komodo dragon): 123026675
Entry
123026675         CDS       T07701                                 
Symbol
MTHFD1
Name
(RefSeq) C-1-tetrahydrofolate synthase, cytoplasmic
  KO
K00288  methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase [EC:1.5.1.5 3.5.4.9 6.3.4.3]
Organism
vko  Varanus komodoensis (Komodo dragon)
Pathway
vko00670  One carbon pool by folate
vko01100  Metabolic pathways
vko01240  Biosynthesis of cofactors
vko04981  Folate transport and metabolism
Module
vko_M00141  C1-unit interconversion, eukaryotes
Brite
KEGG Orthology (KO) [BR:vko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    123026675 (MTHFD1)
 09150 Organismal Systems
  09154 Digestive system
   04981 Folate transport and metabolism
    123026675 (MTHFD1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:vko04147]
    123026675 (MTHFD1)
Enzymes [BR:vko01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.5  methylenetetrahydrofolate dehydrogenase (NADP+)
     123026675 (MTHFD1)
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.4  In cyclic amidines
    3.5.4.9  methenyltetrahydrofolate cyclohydrolase
     123026675 (MTHFD1)
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.4  Other carbon-nitrogen ligases
    6.3.4.3  formate---tetrahydrofolate ligase
     123026675 (MTHFD1)
Exosome [BR:vko04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   123026675 (MTHFD1)
SSDB
Motif
Pfam: FTHFS THF_DHG_CYH_C THF_DHG_CYH OCD_Mu_crystall DUF6507
Other DBs
NCBI-GeneID: 123026675
NCBI-ProteinID: XP_044292507
Ensembl: ENSVKKG00000000398
LinkDB
Position
Unknown
AA seq 935 aa
MAPAEILSGKTVSAQVRQRLKNQVAEMKETVPGFRPGLAILQVGDRDDSNLYISMKLKAA
AEIGINASHIKLPNTATEAEVLRCINRLNEDPAVHGFIVQLPLDSNKPINTEKVTNAVSP
EKDVDGLSSINAGKLSRGDLGDCFIPCTPKGCMELIRQTGVEVAGKKAVVIGRSKIVGAP
MHDLLLWNHATVTTCHSKTTSLAEEVSKADILVVAAGKAEMVQGEWIKPGAVVIDCGINH
VPDSTRPSGKRVVGDVAYSAARERAAYITPVPGGVGPMTVAMLMQSTVESAQRFLEKYQP
GKWNIQYNQLSPRTPVPSDIEISRSCIPKAIGELAQEIGLISDEVEFYGQQKAKISLSTL
KRLQDQPNGKYVVVTGITPTPLGEGKSTTTIGLVQALGSHLGQNAFACVRQPSQGPTFGI
KGGAAGGGYSQVVPMEEFNLHLTGDIHAITAANNLVAAAIDARIFHEATQTDQALYSRLV
PSVDGTRKFSDIQLQRLQRLHIMKTDPGALTDEEINRFVRLDIDPDSITWQRVLDTNDRF
LRKVTIGQSLTEKGFSRTTQFDITVASEIMAVLALTDSLENMRQRLGRMVVASSKHGVPI
TTEDLGVSGALAVLMKDAIKPNLMQTLEGNPVFVHAGPFANIAHGNSSVLADKIALKLVG
REGFVVTEAGFGADIGMEKFFDIKCRYSGLQPHVVVLVATVRALKMHGGGPTVTAGVPLP
REYTEENLLLLEKGCSNLMKQIQNARTFGIPVVVAVNAFKSDTEAELELVIRLAKAGGAF
DAVKCTHWAEGGKGAVMLAEAVRRASQAPSSFRFLYNVEQPILNKIRIIAQTIYGADDIE
LLPEAEQKIILYTKQGFGNLPICMAKTHLSLSHDPERKGVPTGFVMPIRDIRASVGAGFL
YPLVGTMSTMPGLPTRPCFYDIDLDPVTGEVIGLF
NT seq 2808 nt   +upstreamnt  +downstreamnt
atggctcccgcggagatcctcagcggaaagaccgtgtccgcgcaagtaaggcagagactg
aagaaccaggtagcagagatgaaggagacagtcccgggtttcaggccaggcctcgcaatt
ctgcaggttggtgatcgggatgattcaaacctctacattagcatgaaactaaaggctgct
gctgagatcggaatcaatgctagtcatatcaagctgccgaacaccgcaacagaagctgag
gtactgaggtgtattaaccgcctgaacgaggaccctgctgttcatggcttcattgtccag
ctacctctggattccaacaagcccatcaacactgagaaagtaacgaatgctgtgtcaccc
gagaaggatgtggatggcttgagcagcatcaatgcgggaaagctctcacggggggacctt
ggggactgcttcatcccatgtaccccgaaaggatgcatggaacttatcaggcagacaggt
gtggaagtggcaggaaaaaaggctgtggttattgggcgcagcaagatcgtcggggctcca
atgcacgacctgctgctctggaaccatgcgacggtgaccacgtgccactccaagaccaca
tcactggctgaggaggtcagcaaagctgatatcttggtggtggcagcgggcaaagctgaa
atggtgcagggtgaatggattaagccaggggcagtggtgatcgactgtggaatcaaccat
gtaccagacagcacaaggcccagtgggaagagggttgtcggggacgttgcttacagtgcc
gcacgagagagagcggcttacatcacccctgtgccaggcggtgttgggccaatgacggtc
gccatgctgatgcaaagtacagtagaaagcgcccaacgttttctagagaaataccagccc
ggcaaatggaatattcagtataaccagctcagtcctagaacgcctgttccaagcgatatt
gaaatatcacggtcgtgcattcccaaggctattggcgagctggcccaagagatcggcttg
atctcggatgaggtggagttctatggtcaacagaaagccaaaatttccctgtcaacactg
aagcgcctccaagaccaaccaaatggcaaatacgttgtggtaaccggtataacgcccacc
ccgctgggagaggggaaaagcaccacgacaatagggctagtgcaagccctggggtcacac
ctcggtcagaacgccttcgcttgtgtccggcagccttcacagggacccacctttggaatt
aaaggtggtgctgctggaggtggctattctcaggtggtccctatggaagagttcaatctc
cacctcacgggggacatccatgccattacggcagccaacaacctggttgctgctgctatt
gatgcgcgcatcttccacgaggcgacacagaccgatcaggctctctattcccgcctggtc
ccttcagtggatggcacaaggaagttctccgacatccagctccagagacttcagagatta
catattatgaagacggacccaggggctttgacagatgaagagataaacagatttgtgaga
ttggatattgatccggacagcataacatggcaaagagtgttggacacaaatgacagattc
ctgcgaaaagtcacaatcggacagtctctgactgagaaggggttctcacgcacaacccag
ttcgacatcacggtagccagtgagatcatggctgtcttggcgctcacggacagtctggag
aacatgaggcagcgtctggggagaatggttgttgcctccagtaagcacggcgttccgatt
actacagaagacctgggagtgagtggcgccctggcggtgttgatgaaagatgcgattaag
ccaaatctcatgcagactttggagggcaatcccgtgtttgtccatgccggcccgtttgcc
aacattgctcatggcaactcatctgtcctggcagacaaaatagctctgaaactcgttggc
agagaaggatttgttgtgacggaagccggctttggggctgatatcggcatggagaagttc
tttgacatcaagtgtcggtattctggcctgcagccccacgtggtggtgttggttgccact
gtccgagcattgaagatgcatggcgggggccccacggtcacagctggcgttcctttgcca
agagaatacaccgaagagaacctcctgcttttggagaagggctgcagtaatttgatgaag
caaattcagaatgccaggacctttggcatcccggttgttgtggccgtcaatgcattcaaa
tctgacacggaggcagaactcgagctggtcatccggctggctaaggcgggaggcgcgttc
gatgctgtcaagtgcacccactgggcagagggcgggaaaggagccgtgatgctggcagag
gccgtgcgcagagcatcgcaggccccgagcagcttcaggttcttgtacaatgtggagcaa
ccaattctaaataagatcagaattatcgcacagactatttatggggctgatgacattgag
ctgctgccagaagcagagcagaaaattatcctgtacaccaagcagggatttggaaacctt
cctatctgcatggcaaaaacacacctgtcgttgtctcatgacccagaacgcaaaggagtg
cccacaggcttcgtcatgcccatcagggatatccgagccagcgtgggtgcgggatttctg
tatccattagtaggaacgatgagcacaatgccgggccttcccaccaggccttgcttctat
gacatcgacctggacccggtgactggagaggtgattggcctgttctaa

DBGET integrated database retrieval system