Entry
Name
Steroid degradation - Streptomyces yunnanensis
Class
Metabolism; Xenobiotics biodegradation and metabolism
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Streptomyces yunnanensis [GN:
syun ]
Gene
Compound
C00674 5alpha-Androstane-3,17-dione
C04793 3,4-Dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione
C04844 3-Hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate
C11354 2-Hydroxy-cis-hex-2,4-dienoate
C14909 9alpha-Hydroxyandrosta-1,4-diene-3,17-dione
C19944 3-Hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione
C20144 Androsta-1,4-diene-3,17-dione
C20199 3-[(3aS,4S,7aS)-7a-Methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate
C20252 5-Androstene-3,17-dione
C20838 3-[(3aS,4S,7aS)-7a-Methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA
C20839 (25R)-3-Oxocholest-4-en-26-oate
C21076 Delta4-Dafachronic acid
Reference
Authors
Ouellet H, Johnston JB, de Montellano PR
Title
Cholesterol catabolism as a therapeutic target in Mycobacterium tuberculosis.
Journal
Reference
Authors
Van der Geize R, Yam K, Heuser T, Wilbrink MH, Hara H, Anderton MC, Sim E, Dijkhuizen L, Davies JE, Mohn WW, Eltis LD
Title
A gene cluster encoding cholesterol catabolism in a soil actinomycete provides insight into Mycobacterium tuberculosis survival in macrophages.
Journal
Reference
Authors
Thomas ST, VanderVen BC, Sherman DR, Russell DG, Sampson NS
Title
Pathway profiling in Mycobacterium tuberculosis: elucidation of cholesterol-derived catabolite and enzymes that catalyze its metabolism.
Journal
Reference
Authors
Driscoll MD, McLean KJ, Levy C, Mast N, Pikuleva IA, Lafite P, Rigby SE, Leys D, Munro AW
Title
Structural and biochemical characterization of Mycobacterium tuberculosis CYP142: evidence for multiple cholesterol 27-hydroxylase activities in a human pathogen.
Journal
Reference
Authors
Johnston JB, Ouellet H, Ortiz de Montellano PR
Title
Functional redundancy of steroid C26-monooxygenase activity in Mycobacterium tuberculosis revealed by biochemical and genetic analyses.
Journal
Reference
Authors
Yang X, Dubnau E, Smith I, Sampson NS
Title
Rv1106c from Mycobacterium tuberculosis is a 3beta-hydroxysteroid dehydrogenase.
Journal
Reference
Authors
Lack NA, Yam KC, Lowe ED, Horsman GP, Owen RL, Sim E, Eltis LD
Title
Characterization of a carbon-carbon hydrolase from Mycobacterium tuberculosis involved in cholesterol metabolism.
Journal
Reference
Authors
Kreit J, Sampson NS
Title
Cholesterol oxidase: physiological functions.
Journal
Reference
Authors
Horinouchi M, Hayashi T, Kudo T
Title
Steroid degradation in Comamonas testosteroni.
Journal
Reference
Authors
Horinouchi M, Kurita T, Hayashi T, Kudo T
Title
Steroid degradation genes in Comamonas testosteroni TA441: Isolation of genes encoding a Delta4(5)-isomerase and 3alpha- and 3beta-dehydrogenases and evidence for a 100 kb steroid degradation gene hot spot.
Journal
Related pathway
KO pathway
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