KEGG   Streptomyces leeuwenhoekii: sle_24580
Entry
sle_24580         CDS       T04414                                 
Symbol
sle_24580
Name
(GenBank) 2-oxoglutarate decarboxylase
  KO
K01616  multifunctional 2-oxoglutarate metabolism enzyme [EC:2.2.1.5 4.1.1.71 1.2.4.2 2.3.1.61]
Organism
sle  Streptomyces leeuwenhoekii
Pathway
sle00020  Citrate cycle (TCA cycle)
sle00630  Glyoxylate and dicarboxylate metabolism
sle00785  Lipoic acid metabolism
sle01100  Metabolic pathways
sle01110  Biosynthesis of secondary metabolites
sle01120  Microbial metabolism in diverse environments
sle01200  Carbon metabolism
sle01210  2-Oxocarboxylic acid metabolism
Module
sle_M00009  Citrate cycle (TCA cycle, Krebs cycle)
sle_M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
Brite
KEGG Orthology (KO) [BR:sle00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00020 Citrate cycle (TCA cycle)
    sle_24580 (sle_24580)
   00630 Glyoxylate and dicarboxylate metabolism
    sle_24580 (sle_24580)
  09108 Metabolism of cofactors and vitamins
   00785 Lipoic acid metabolism
    sle_24580 (sle_24580)
Enzymes [BR:sle01000]
 1. Oxidoreductases
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.4  With a disulfide as acceptor
    1.2.4.2  oxoglutarate dehydrogenase (succinyl-transferring)
     sle_24580 (sle_24580)
 2. Transferases
  2.2  Transferring aldehyde or ketonic groups
   2.2.1  Transketolases and transaldolases
    2.2.1.5  2-hydroxy-3-oxoadipate synthase
     sle_24580 (sle_24580)
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.61  dihydrolipoyllysine-residue succinyltransferase
     sle_24580 (sle_24580)
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.1  Carboxy-lyases
    4.1.1.71  2-oxoglutarate decarboxylase
     sle_24580 (sle_24580)
SSDB
Motif
Pfam: E1_dh 2-oxoacid_dh OxoGdeHyase_C Transket_pyr 2-oxogl_dehyd_N
Other DBs
NCBI-ProteinID: CQR61919
UniProt: A0A0F7VNZ9
LinkDB
Position
chromosome:2988398..2992198
AA seq 1266 aa
MSPQSPSNSSSPTTDTDRAGKNPAAAFGANEWLVDEIYQQYLQDPNSVDRAWWDFFADYK
PGAAAAQASSGAAATGAAETTSTARPAAQAPQAPAPAAQAPAPAAQAPAPAAPEKPAAAA
KPAAAAAKPAAAPQPKAAPAKAPAEGPELVTLRGPAAAVAKNMDASLEMPTATSVRAVPV
KLLFDNRIVINNHLKRARGGKISFTHIIGYAMVQAIKAMPSMNWSYGLKDGKPTLIKPEH
VNLGLAIDLVKPNGDRQLVVAAIKKAETLNFFEFWQAYEDIVRRAREGKLTMDDFTGVTV
SLTNPGGLGTVHSVPRLMPGQSVIMGVGSMDYPAEFQGTSQDTLNKLGISKVMTLTSTYD
HRVIQGAASGEFLRVVANLLLGENGFYDDIFEALRIPYEPVRWLKDIDASHDDDVTKAAR
VFELIHSYRVRGHVMADTDPLEYQQRKHPDLDITEHGLTLWDLEREFAVGGFAGKSMMKL
RDILGVLRDSYCRTTGIEFMHIQDPKQRKWIQDRVERPHAKPEREEQLRILRRLNAAEAF
ETFLQTKYVGQKRFSLEGGESVIPLLDAVLDSAAESRLDEVVVGMAHRGRLNVLANIVGK
SYAQIFREFEGNLDPKSMHGSGDVKYHLGAEGTFTGLDGEQIKVSLVANPSHLEAVDPVL
EGVARAKQDIINKGGTDFTVLPVAIHGDAAFAGQGVVAETLNMSQLRGYRTGGTVHIVIN
NQVGFTAAPESSRSSMYATDVARMIEAPIFHVNGDDPEACVRVARLAFEFRQAFNKDVVI
DLICYRRRGHNESDNPAFTQPLMYDLIDKKRSVRKLYTESLIGRGDITLEEAEQALQDYQ
GQLEKVFTEVREATSQPSAVEPSDPQAEFPVAVNTAVTTETVKRIAESQVNIPDHITVHP
RLLPQLQRRATMVEDGTIDWGMGETLAFGSLLLEGVPVRLAGQDSQRGTFGQRHAVIIDR
NTGEEYTPLQYLSEEQARLNVYNSLLSEYAAMGFEYGYSLARPDALVLWEAQFGDFVNGA
QTVVDEFISSAEQKWGQTSGVVLLLPHGYEGQGPDHSSARPERFLQLCAQNNMTVAMPTS
PSNYFHLLRWQVHNPHHKPLVVFTPKSMLRLKAAASKAEEFTTGQFRPVIGDASVDAAAV
KKVVFCSGKVYYDLDAERKKRGVTDTAIIRIERLYPLPGTELQAEIAKYPNAEKYLWAQE
EPANQGAWPFIALNLIDHLDLAVGADVPHGERLRRISRPHSSSPAVGSAKRHQAEQEQLV
REVFEA
NT seq 3801 nt   +upstreamnt  +downstreamnt
gtgtcgccacagtcccccagtaactcgagctcccccacgaccgacaccgaccgggcgggc
aagaaccccgccgccgcgttcggtgccaacgagtggctcgtcgacgagatctatcagcag
tacctccaggacccgaactccgtggaccgagcctggtgggacttcttcgccgactacaag
ccgggggcggccgccgcccaggcttcgtcgggtgctgcggccacgggggccgcagagacc
accagcacggcccggcccgccgcccaggccccccaggccccggcgccggctgcccaggcc
ccggctccagccgcacaggccccggctccggccgccccggagaagcccgccgcggccgcc
aagcccgccgccgcggccgcgaagcccgcggccgcgccgcagcctaaggccgcgcccgcc
aaggcgcccgccgagggtcccgagctggtgaccctgcgcggtcccgcggcggccgtcgcc
aagaacatggacgcctcgctggagatgccgacggccacctcggtccgcgccgtcccggtg
aagctgctgttcgacaaccgcatcgtcatcaacaaccacctcaagcgcgcccgcggcggg
aagatctccttcacgcacatcatcgggtacgcgatggtgcaggccatcaaggccatgccg
tccatgaactggtcgtacggcctcaaggacggcaagccgaccctgatcaagccggagcac
gtcaacctcggtctcgccatcgacctggtcaagcccaacggcgaccgccagctcgtcgtc
gcggcgatcaagaaggccgagacgctgaacttcttcgagttctggcaggcctacgaggac
atcgtccgccgcgcccgcgagggcaagctcacgatggacgacttcaccggtgtgacggtc
tccctgaccaaccccggcggcctcggcaccgtccactccgtcccgcgcctgatgcccggc
cagtcggtgatcatgggcgtcggctcgatggactacccggccgagttccagggcaccagc
caggacacgctcaacaagctgggcatctccaaggtcatgaccctgacgtcgacctacgac
caccgggtcatccagggcgccgcctccggcgagttcctgcgcgtcgtcgccaacctgctg
ctcggcgagaacggcttctacgacgacatcttcgaggcgctgcgcatcccctacgagccg
gtccgctggctcaaggacatcgacgccagccacgacgacgacgtcaccaaggccgcccgc
gtcttcgagctgatccactcctaccgggtccgcggccacgtcatggccgacaccgacccg
ctggagtaccagcagcgcaagcaccccgacctggacatcaccgagcacgggctcaccctg
tgggacctggagcgcgagttcgccgtcggcggcttcgccggcaagtcgatgatgaagctg
cgcgacatcctcggcgtgctgcgcgactcgtactgccgcaccaccggcatcgagttcatg
cacatccaggaccccaagcagcgcaagtggatccaggaccgcgtggagcgcccgcacgcc
aagcccgagcgcgaggagcagctccgcatcctgcgccggctgaacgcggcggaggcgttc
gagaccttcctgcagacgaagtacgtcggccagaagcgcttctcgctggagggcggcgag
tccgtcatcccgctgctggacgcggtgctggactcggcggccgagtcccgcctggacgag
gtcgtcgtcggcatggcccaccgcggccggctgaacgtgctcgccaacatcgtcggcaag
tcctacgcgcagatcttccgcgagttcgagggcaacctcgacccgaagtcgatgcacggc
tccggcgacgtgaagtaccacctgggcgccgaaggcaccttcaccggcctggacggcgag
cagatcaaggtctccctggtcgcgaacccctcccacctggaggccgtcgacccggtcctg
gagggcgtcgcccgcgccaagcaggacatcatcaacaagggcggcacggacttcaccgtc
ctgccggtggcgatccacggcgacgcggccttcgcgggccagggcgtggtggccgagacc
ctgaacatgtcgcagctccgcggctaccgcaccggcggcacggtccacatcgtcatcaac
aaccaggtcggcttcaccgcggccccggagtcctcgcgctcctccatgtacgccaccgac
gtggcgcgcatgatcgaggcgccgatcttccacgtcaacggcgacgacccggaggcgtgc
gtccgcgtggcgcggctggccttcgagttccgccaggcgttcaacaaggacgtggtgatc
gacctcatctgctaccgccgccgcggtcacaacgagtcggacaacccggccttcacccag
ccgctgatgtacgacctgatcgacaagaagcgctcggtgcgcaagctgtacaccgagtcc
ctcatcggtcgcggcgacatcaccctggaagaggccgagcaggcccttcaggactaccag
ggccagctcgagaaggtcttcaccgaggtccgcgaggccacctcgcagccctccgccgtg
gagccctccgacccgcaggccgagttcccggtcgccgtgaacaccgcggtgaccacggag
accgtcaagcggatcgccgagtcccaggtcaacatccccgaccacatcacggtccacccg
cgcctgctgccgcagctccagcgccgggcgacgatggtcgaggacggcacgatcgactgg
ggcatgggcgagaccctcgccttcggctccctgctgctggagggcgtcccggtccgcctg
gcgggtcaggactcccagcgcggcaccttcggccagcgccacgcggtcatcatcgaccgc
aacaccggcgaggagtacacgccgctgcagtacctctccgaggagcaggcgcggctgaac
gtgtacaactcgctgctgtcggagtacgcggcgatgggcttcgagtacggctactcgctg
gcccgcccggacgcgctggtgctgtgggaggcccagttcggcgacttcgtcaacggcgcg
cagacggtcgtggacgagttcatctcctccgcggagcagaagtggggccagacctccggc
gtcgtcctgctcctcccccacggctacgagggccagggcccggaccactcctcggcccgc
ccggagcgcttcctccagctctgcgcccagaacaacatgacggtcgccatgccgacctcg
ccgtcgaactacttccacctcctgcggtggcaggtgcacaacccgcaccacaagccgctg
gtcgtcttcaccccgaagtcgatgctgcgcctgaaggcggcggcctcgaaggcggaggag
ttcaccaccggccagttccgcccggtcatcggcgacgcctccgtcgacgcggccgcggtc
aagaaggtcgtcttctgctccggcaaggtctactacgacctcgacgccgagcggaagaag
cgcggtgtgacggacacggcgatcatccgcatcgagcgcctgtacccgctgccgggtacc
gagctccaggcggagatcgccaagtacccgaacgccgagaagtacctgtgggcccaggag
gagccggcgaaccagggtgcctggccgttcatcgcgctcaacctgatcgaccacctggac
ctggccgtcggcgccgatgtcccgcacggtgagcgcctgcgccgcatctcgcgtccgcac
agctcgtccccggccgtcggttccgcgaagcggcaccaggccgagcaggagcagctcgtg
cgtgaggtgttcgaggcgtaa

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