KEGG   Saccharomyces cerevisiae (budding yeast): YGR204W
Entry
YGR204W           CDS       T00005                                 
Symbol
ADE3
Name
(RefSeq) trifunctional formate-tetrahydrofolate ligase/methenyltetrahydrofolate cyclohydrolase/methylenetetrahydrofolate dehydrogenase ADE3
  KO
K00288  methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase [EC:1.5.1.5 3.5.4.9 6.3.4.3]
Organism
sce  Saccharomyces cerevisiae (budding yeast)
Pathway
sce00670  One carbon pool by folate
sce01100  Metabolic pathways
sce01240  Biosynthesis of cofactors
sce04981  Folate transport and metabolism
Module
sce_M00141  C1-unit interconversion, eukaryotes
Brite
KEGG Orthology (KO) [BR:sce00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    YGR204W (ADE3)
 09150 Organismal Systems
  09154 Digestive system
   04981 Folate transport and metabolism
    YGR204W (ADE3)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:sce04147]
    YGR204W (ADE3)
Enzymes [BR:sce01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.5  methylenetetrahydrofolate dehydrogenase (NADP+)
     YGR204W (ADE3)
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.4  In cyclic amidines
    3.5.4.9  methenyltetrahydrofolate cyclohydrolase
     YGR204W (ADE3)
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.4  Other carbon-nitrogen ligases
    6.3.4.3  formate---tetrahydrofolate ligase
     YGR204W (ADE3)
Exosome [BR:sce04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   YGR204W (ADE3)
SSDB
Motif
Pfam: FTHFS THF_DHG_CYH_C THF_DHG_CYH Shikimate_DH
Other DBs
NCBI-GeneID: 853118
NCBI-ProteinID: NP_011720
SGD: S000003436
UniProt: P07245
LinkDB
Position
VII:905934..908774
AA seq 946 aa
MAGQVLDGKACAQQFRSNIANEIKSIQGHVPGFAPNLAIIQVGNRPDSATYVRMKRKAAE
EAGIVANFIHLDESATEFEVLRYVDQLNEDPHTHGIIVQLPLPAHLDEDRITSRVLAEKD
VDGFGPTNIGELNKKNGHPFFLPCTPKGIIELLHKANVTIEGSRSVVIGRSDIVGSPVAE
LLKSLNSTVTITHSKTRDIASYLHDADIVVVAIGQPEFVKGEWFKPRDGTSSDKKTVVID
VGTNYVADPSKKSGFKCVGDVEFNEAIKYVHLITPVPGGVGPMTVAMLMQNTLIAAKRQM
EESSKPLQIPPLPLKLLTPVPSDIDISRAQQPKLINQLAQELGIYSHELELYGHYKAKIS
PKVIERLQTRQNGKYILVSGITPTPLGEGKSTTTMGLVQALTAHLGKPAIANVRQPSLGP
TLGVKGGAAGGGYSQVIPMDEFNLHLTGDIHAIGAANNLLAAAIDTRMFHETTQKNDATF
YNRLVPRKNGKRKFTPSMQRRLNRLGIQKTNPDDLTPEEINKFARLNIDPDTITIKRVVD
INDRMLRQITIGQAPTEKNHTRVTGFDITVASELMAILALSKDLRDMKERIGRVVVAADV
NRSPVTVEDVGCTGALTALLRDAIKPNLMQTLEGTPVLVHAGPFANISIGASSVIADRVA
LKLVGTEPEAKTEAGYVVTEAGFDFTMGGERFFNIKCRSSGLTPNAVVLVATVRALKSHG
GAPDVKPGQPLPSAYTEENIEFVEKGAANMCKQIANIKQFGVPVVVAINKFETDTEGEIA
AIRKAALEAGAFEAVTSNHWAEGGKGAIDLAKAVIEASNQPVDFHFLYDVNSSVEDKLTT
IVQKMYGGAAIDILPEAQRKIDMYKEQGFGNLPICIAKTQYSLSHDATLKGVPTGFTFPI
RDVRLSNGAGYLYALAAEIQTIPGLATYAGYMAVEVDDDGEIDGLF
NT seq 2841 nt   +upstreamnt  +downstreamnt
atggctggtcaagtgttggacggcaaagcatgcgctcagcagtttagaagcaatattgct
aatgaaatcaaaagcattcaaggtcacgtgcctgggtttgcacctaaccttgccatcatt
caagtaggcaacagaccagactcagccacatatgtacgcatgaagcgtaaggcagctgaa
gaggccggcattgttgctaatttcattcatttagatgaatccgctactgaatttgaagtt
ctgcgttacgtggaccagctgaatgaggacccacatacacacggtattatcgtgcaacta
ccattacccgctcatttggacgaggatagaatcacctcgagagtgttggcagaaaaggac
gtggacgggttcgggcccaccaacattggcgaattgaataagaagaacggacacccattc
tttttgccctgcacgcccaaggggatcattgagctgcttcacaaggccaacgtcacgatt
gaaggttcccggtccgttgtgatcggaagatctgacattgttggctctcctgttgcagaa
ttgttaaaatctctaaactccaccgtcaccatcactcattctaaaacccgtgatatcgca
tcatacttacacgacgcggacatcgtagtcgttgccatcggccaaccagaatttgtgaag
ggtgaatggttcaaaccaagagacggcacttccagtgataagaaaaccgtggtaattgat
gttggcaccaactacgttgctgatccttccaaaaagtccggtttcaaatgtgttggtgac
gttgagttcaatgaagcaatcaaatacgtccatctaatcactccagtgcccggtggtgtg
ggccccatgacggtggctatgttaatgcaaaataccttgattgctgccaaacgccaaatg
gaagaatcctcgaagcctttgcagattcctcccttgccattgaagttgctaacacctgtt
ccttccgatatagacatctccagagcacaacagccaaagcttatcaaccagcttgctcaa
gaattgggtatttactctcatgagttggagctgtacggacattacaaggccaaaatttct
cctaaagtcatcgaaaggctgcagacgcgccaaaatggtaagtacatcttggtgtctggt
atcacaccaacaccactgggagagggtaaatccactacaacaatgggtcttgtccaggca
ctaacggctcacttgggcaagccagccattgcgaacgtcagacaaccctccctaggaccc
actttaggtgtcaaaggtggtgctgcgggtggtggttattcccaagtcatcccaatggac
gaattcaacttacatttgactggtgacattcacgccattggtgcggctaacaacctactt
gctgccgctattgacactagaatgttccatgagaccactcaaaagaacgacgctaccttc
tacaacagactagtgcctagaaagaacggaaagagaaagtttactccctccatgcaaaga
agattgaacagactgggtattcaaaagaccaaccccgatgatctaacacccgaagagatc
aacaaattcgccagattgaacattgacccggacactattactatcaagagggtggtcgat
atcaacgacagaatgttaagacaaatcaccattggtcaagcccctaccgagaagaaccac
acaagagttactggattcgatatcaccgttgcttctgaattgatggctattcttgctctt
tcaaaggacttgagggacatgaaggaacgtattggaagagtcgttgttgctgctgacgta
aacaggtctccagtcactgttgaagatgtgggttgtaccggtgccttaaccgctttatta
agagacgctatcaagcccaacttgatgcaaactttagaaggtactcctgtcttggtccat
gccggcccatttgccaacatctctatcggtgcctcttctgttattgctgatcgcgtggct
ttgaaattggttggtaccgagccagaggcaaaaacagaagctggttatgtggttactgaa
gcagggttcgatttcactatgggtggtgaaagattcttcaacatcaagtgccgttcctct
ggattgacacctaatgctgtggtcttggttgctactgttagggcattgaagtcacacggt
ggtgctccagatgtcaaacctggccaacctttaccttccgcatacactgaagagaatatc
gagtttgtcgaaaaaggtgccgctaacatgtgtaaacaaattgccaacattaagcaattt
ggcgtccccgtcgttgtcgcaattaacaagtttgaaactgacactgaaggtgaaatagcc
gccattagaaaagccgctttggaagctggtgcatttgaagccgtaacctctaaccattgg
gccgaaggtggtaaaggtgctatcgacttggccaaggccgtcatcgaagcttccaaccaa
ccagtggacttccatttcctatatgacgttaactcctccgttgaagacaaattaactact
atcgttcaaaagatgtacggtggtgccgcaatcgatatcttgcctgaagcacaacgcaag
attgacatgtacaaggaacaaggtttcggtaacttgccaatttgtatcgccaagacacaa
tactctttatcccacgatgcaactttgaaaggtgttccaaccgggttcactttccccatc
agagacgtcagattgtctaatggtgctggatacttatacgctcttgccgccgaaatacaa
accattcctggtttggctacctatgctggttacatggccgtggaagtcgatgatgacggt
gagatcgatggcctgttctaa

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