KEGG   Sorex araneus (European shrew): 101558074
Entry
101558074         CDS       T07854                                 
Symbol
MTHFD1
Name
(RefSeq) C-1-tetrahydrofolate synthase, cytoplasmic
  KO
K00288  methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase [EC:1.5.1.5 3.5.4.9 6.3.4.3]
Organism
sara  Sorex araneus (European shrew)
Pathway
sara00670  One carbon pool by folate
sara01100  Metabolic pathways
sara01240  Biosynthesis of cofactors
sara04981  Folate transport and metabolism
Module
sara_M00141  C1-unit interconversion, eukaryotes
Brite
KEGG Orthology (KO) [BR:sara00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    101558074 (MTHFD1)
 09150 Organismal Systems
  09154 Digestive system
   04981 Folate transport and metabolism
    101558074 (MTHFD1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:sara04147]
    101558074 (MTHFD1)
Enzymes [BR:sara01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.5  methylenetetrahydrofolate dehydrogenase (NADP+)
     101558074 (MTHFD1)
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.4  In cyclic amidines
    3.5.4.9  methenyltetrahydrofolate cyclohydrolase
     101558074 (MTHFD1)
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.4  Other carbon-nitrogen ligases
    6.3.4.3  formate---tetrahydrofolate ligase
     101558074 (MTHFD1)
Exosome [BR:sara04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   101558074 (MTHFD1)
SSDB
Motif
Pfam: FTHFS THF_DHG_CYH_C THF_DHG_CYH OCD_Mu_crystall
Other DBs
NCBI-GeneID: 101558074
NCBI-ProteinID: XP_004612420
LinkDB
Position
Unknown
AA seq 935 aa
MAPAEILNGKAVSAQIRERLKNQVTQMKEQVPGFSPGLAILQVGDRDDSNLYINVKLKAA
EEIGIKTTHIKLPRTVTEPEVLKCIASLNEDLTVHGFIVQLPLDSENPINTEAVINAISP
EKDVDGLTSISAGKLARGDLNDCFIPCTPKGCLELIKETGVQIAGRHAVVIGRSKIVGAP
MHDLLLWNNATVTTCHSKTANLNEEVNKGDILVVATGQPEMVKGEWIKPGAIVIDCGINY
IPDDTKPNGKKVVGDVAYDEARERAAFITPVPGGVGPMTVAMLMQSTVDSAQHFLEKSKP
GKWIIQYNSLTLKTPVPSDIDISRSCKPKPIGNLAREIGLLSEEVELYGETKAKVLLSTL
ERLKHQPDGKYVVVTGITPTPLGEGKSTTTIGLVQALGAHLHQNVFACVRQPSQGPTFGI
KGGAAGGGYSQVIPMEEFNLHLTGDIHAITAANNLVAAAIDARMFHELTQTDKALFNRLV
PSVNGVRKFSDIQIRRLQRLGIQKTDPSTLTDEEINRFARLDIDPDTITWQRVLDTNDRF
LRKITIGQAPTEKGYTRTAQFDISVASEIMAVLALTTSLEDMRERLGRMVVASSKKGEPV
SAEDLGVSGALTVLMKDAIKPNLMQTLEGTPVFVHAGPFANIAHGNSSIIADRIALKLVG
PEGFVVTEAGFGADIGMEKFFNIKCRYSGLRPHVVVLVATIRALKMHGGGPTVTAGLPLP
KAYIEEDLELVEKGFSNLKKQIENAKMFGVPVVVAVNAFKTDTETELDLVSRLAKENGAF
DAVKCTHWAEGGKGALGLAQAVQRAAQAPSHFQLLYDVQLPVEEKIRIIAQKIYGADDIE
LLPEAQHKAEVYTKQGFGNLPICMAKTHLSLSHNPEQKGVPTGFVLPIRDIRASVGAGFL
YPLVGTMSTMPGLPTRPCFYDIDLDPETEQVNGLF
NT seq 2808 nt   +upstreamnt  +downstreamnt
atggctccggcggaaatcctcaacgggaaggcggtctccgcgcaaataagggagcgtctg
aagaaccaagttactcaaatgaaggagcaggtacctggttttagcccagggctggcaatt
ttacaggttggcgacagagatgattccaatctttatataaacgtgaagctgaaggctgcc
gaagagattgggatcaaaaccacccacataaagttaccaagaacagtcacagaacctgag
gtgttgaagtgtattgcatctttgaatgaggacctcactgtccatgggttcatagtgcag
ctccctttagattcagaaaatcccattaacaccgaagcagtgatcaatgccatctctcct
gaaaaggatgtggatggtttgacaagcatcagtgctgggaaacttgctagaggtgacctg
aatgactgtttcatcccttgtacaccaaaaggatgcttggaactcatcaaggagacaggg
gtgcagattgctggccggcacgctgtggtgatcggccgcagtaagatagtcggtgccccg
atgcacgacttgcttctgtggaacaatgccactgtaaccacctgccactcgaagactgcc
aatctcaatgaagaggtgaataaaggtgacatcctggtggttgcaactggtcagccagaa
atggtgaaaggggagtggatcaaacctggagcaatagtcattgactgtgggatcaattac
atcccagatgataccaaaccaaatgggaaaaaagtcgtgggtgacgtggcatatgatgag
gcccgagagagggcagccttcatcactcccgtgccgggcggcgttggacccatgacagtg
gcaatgctaatgcagagcacagtagacagtgcacagcatttcctggagaaatctaagcct
ggaaaatggataattcaatataacagccttacgctcaagacacctgttccaagtgacatt
gacatatcacgatcttgtaagccgaagcctattggtaatctggctcgagagattggttta
ctctctgaagaggtggaattatatggtgaaacaaaggccaaagttctactgtcgacactg
gaacgcctgaagcatcagcctgatgggaaatatgtggtggtcactggaataactccaacg
ccactgggagaagggaaaagcaccactacgattgggctggtgcaagccctcggtgcccat
cttcaccagaatgtcttcgcctgtgtgcggcagccctctcagggccccacctttggaatc
aaaggtggcgctgcaggaggcggctactcacaggtcattcctatggaagagttcaatctc
cacctcacgggtgatattcacgccatcactgctgctaataatctagttgctgcagccata
gatgcccggatgttccatgaacttacccagacagacaaggctctctttaatcgtttggta
ccttcagtaaacggagtgcgaaagttctctgatatccagatccgacggttacagagactg
gggattcaaaagactgatccttccacgctgacagatgaagagatcaacagatttgcaaga
ttggacattgatccagacaccattacttggcaaagagtgttggataccaatgatcgattc
ctgaggaagatcacaattggccaggctccaacagagaaaggatacacacggacggctcaa
tttgacatctctgtggccagtgaaatcatggctgttctggctctcaccacctctctggaa
gatatgagagagagactgggcagaatggtggtggcctccagcaagaaaggggagcccgtc
agtgctgaagatctgggagtgagtggtgccctgaccgtacttatgaaagatgcaatcaag
cccaatctcatgcagacactggagggtaccccagtgttcgttcacgcggggccatttgcc
aacattgcccatggcaattcctccatcattgcagacaggattgcgctcaagctggttggc
cctgaaggatttgtagtgaccgaggcaggatttggggctgatattggcatggagaagttt
tttaacatcaagtgccgctattctggcctccgccctcatgtggtggtgcttgtggccacc
atcagggctcttaagatgcacggagggggccctacggtcactgctggactgcctcttccc
aaggcttacattgaggaggacctggaactggtggaaaagggcttcagtaacctgaagaaa
caaatcgaaaatgccaaaatgttcggggttccagttgtggtggctgtgaatgcattcaag
acggacacagagactgagctggaccttgtcagccgccttgccaaggagaatggggctttt
gacgctgtgaagtgtactcactgggcagaagggggcaagggagccctgggcctggctcag
gccgtccagagagcagctcaggcacccagccacttccagctcctttatgacgtccagctc
ccagttgaggagaaaatcagaatcatcgcacagaagatctatggggcagatgacattgaa
ttgctgccggaagctcagcacaaagctgaagtctacacgaagcagggctttggaaacctg
cccatctgcatggccaaaacacacttgtctttgtctcataatcctgagcagaaaggtgtg
cctacaggctttgtcctgcccattcgagacatccgcgcaagtgttggcgctggttttctg
taccccctggtgggcacgatgagcacaatgcctggactccctacccggccctgtttttat
gacattgacttggaccctgaaactgagcaggtgaacgggctgttctaa

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