KEGG   Rousettus aegyptiacus (Egyptian rousette): 107509318
Entry
107509318         CDS       T06036                                 
Symbol
MTHFD1
Name
(RefSeq) C-1-tetrahydrofolate synthase, cytoplasmic isoform X1
  KO
K00288  methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase [EC:1.5.1.5 3.5.4.9 6.3.4.3]
Organism
ray  Rousettus aegyptiacus (Egyptian rousette)
Pathway
ray00670  One carbon pool by folate
ray01100  Metabolic pathways
ray01240  Biosynthesis of cofactors
ray04981  Folate transport and metabolism
Module
ray_M00141  C1-unit interconversion, eukaryotes
Brite
KEGG Orthology (KO) [BR:ray00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    107509318 (MTHFD1)
 09150 Organismal Systems
  09154 Digestive system
   04981 Folate transport and metabolism
    107509318 (MTHFD1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:ray04147]
    107509318 (MTHFD1)
Enzymes [BR:ray01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.5  methylenetetrahydrofolate dehydrogenase (NADP+)
     107509318 (MTHFD1)
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.4  In cyclic amidines
    3.5.4.9  methenyltetrahydrofolate cyclohydrolase
     107509318 (MTHFD1)
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.4  Other carbon-nitrogen ligases
    6.3.4.3  formate---tetrahydrofolate ligase
     107509318 (MTHFD1)
Exosome [BR:ray04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   107509318 (MTHFD1)
SSDB
Motif
Pfam: FTHFS THF_DHG_CYH_C THF_DHG_CYH
Other DBs
NCBI-GeneID: 107509318
NCBI-ProteinID: XP_015997229
UniProt: A0A7J8IPA8
LinkDB
Position
Unknown
AA seq 935 aa
MAPAEILNGKEVSAQIRARLKNQVIRMKEQAPGFIPGLAILQVGNRDDSNLYINVKLKAA
EEIGIKATHIKLPRSATESEVLKCVTSLNEDLTIHAFIVQLPLDSENPINTEAVVNAIAP
EKDVDGLTNISAGKLARGDLNDCFIPCTPKGCLELIKETGVQIAGTHAVVVGRSKIVGAP
MHDLLLWNHATVTTCHSKTANLDEEVNKGDILVVAAGQPEMVKGEWIKPGAIVIDCGINY
VPDDTKPNGRKVVGDVAYSEAKERAGFITPVPGGVGPMTVAMLMQSTVESANRFLEKFKP
GKWLIQYNHLNLKTPVPSDIDISRSCKPKPICNLAREIGLFSEEVESYGATKAKVLLSVL
ERLKQQPDGKYVVVTGITPTPLGEGKSTTTIGLVQALGAHLHQNVFACVRQPSQGPTFGI
KGGAAGGGYSQVIPMEEFNLHLTGDIHAITAANNLVAAAIDARMFHELTQTDKALFNRLV
PSVNGVRKFSDIQIRRLRRLGIEKTDPTTLTDEEINRFARLDIDPETITWQRVLDTNDRF
LRKITIGQAPTEKGYTRTAQFDISVASEIMAVLALTSSLEDMRERLSKMVVASSKKGEPI
SAEDLGVSGALAVLMKDAIKPNLMQTLEGTPVFVHAGPFANIAHGNSSTIADRIALKLVG
PEGFVVTEAGFGADIGMEKFFNIKCRYSGLRPHAVVLVATVRALKMHGGGPTVTAGLPLP
KAYIEENLELVEKGFSNLRKQIENARMFGVPVVVAVNAFKTDTEAELDLVSRLAKEHGAF
DAVKCTHWAEGGKGALALAQAVQRAAQSPSSFQLLYDLKLPVEDKIRIIAQKIYGADDIE
LLPEAQHKAEVYTKQGFGNLPICMAKTHLSLSHNPEQKGAPTGFVLPIRDIRASVGAGFL
YPLVGTMTTMPGLPTRPCFYDIDLDPETEQVNGLF
NT seq 2808 nt   +upstreamnt  +downstreamnt
atggcgccggcggaaatcttgaacgggaaggaggtctccgcgcaaataagggcgcgactg
aagaaccaagtcattcggatgaaggagcaagcacctggttttataccaggtctggcaatt
ttacaggttggcaatagagatgattccaatctttatataaatgtgaagctgaaggctgct
gaagagattgggatcaaagccactcacattaaattaccaagatctgccacagaatctgag
gtgttaaagtgcgtaacgtctttgaatgaagacctcaccatacatgccttcatagtgcag
ctacctttagattcagagaatcctattaacactgaagcagtggtcaatgctattgcacct
gaaaaggatgtggatggattgactaacatcagtgctggaaaacttgctagaggtgaccta
aatgactgtttcatcccttgtacacctaaaggatgcttggaactcatcaaagagacaggg
gtacagattgccggaacgcacgctgtggtcgttggacgcagtaaaatagtcggtgccccc
atgcatgacttgcttctgtggaaccatgccacagtgaccacctgccactccaagactgcc
aatctagacgaggaggtaaataaaggtgacatcctggtggttgcagctggtcagcctgaa
atggtgaaaggggaatggatcaaacctggggcaatagtcatcgactgtggaatcaattac
gtcccagacgatacaaaaccaaatgggagaaaagttgtgggcgatgtggcatacagtgag
gccaaagagagggcaggcttcatcactcctgttcctggtggcgttgggcccatgacagtg
gcaatgctaatgcagagcacagtagagagtgcaaatcgtttcctggagaaatttaagcca
ggaaagtggctgattcagtataaccaccttaacctcaagacacctgttccaagtgacatt
gatatttcacggtcctgcaagccaaagcccatttgtaacctggctcgagaaattggtctg
ttctctgaagaggtggaatcttacggtgcaacgaaggccaaagtcttgctgtccgtgctg
gaacgcctgaagcagcagcccgatgggaaatacgtagtggtgacgggaataactcccaca
cccctgggagaagggaaaagcacgaccacaattgggctggtgcaagcccttggcgcccac
ctccatcagaacgtctttgcatgtgtacgacagccttctcagggccccacctttggaata
aaaggtggtgctgcaggcggtggctactctcaggtcattcctatggaagagtttaatctc
cacctcactggtgacatccacgccatcactgcagctaataacctcgttgctgcagccatt
gatgcccggatgttccatgaactgacccagactgacaaggctctctttaatcgtttggta
ccgtcagtaaatggagtgagaaagttctctgatatccaaatacgaaggttacggagacta
ggcattgaaaagactgatcctaccacactgacagatgaagagataaacagatttgcaaga
ttggatatcgatccagaaaccataacttggcaaagagtgttggataccaatgatcgattc
ctgaggaaaatcacaattggacaggctccaacggagaaagggtacacacggacggcccag
tttgatatctctgtagccagtgaaatcatggctgtcctggctctcaccagttccctagaa
gacatgagagagagattgagcaaaatggtggtggcatccagcaagaaaggggagcccatc
agtgccgaagatctgggagtgagtggtgcgttggcagtgctcatgaaagatgcgatcaag
cccaatctcatgcagaccttagagggcactccggtatttgttcatgctggaccatttgcc
aacattgcacatgggaattcctctaccattgcagaccggattgcactcaagcttgttggc
cctgaagggtttgtagtgaccgaagctggatttggagcagacattggaatggaaaagttt
tttaacatcaaatgccggtattctggtctccgccctcatgcagtggtgcttgttgccact
gtcagggctcttaaaatgcatggaggcggccccacggttactgctggacttcctcttccc
aaggcttacatagaggagaatttagaactggttgaaaaaggcttcagtaacttgaggaaa
caaattgaaaatgccagaatgtttggggttccagtagtagtagccgtgaatgcattcaag
acagatacggaggccgagctagacctcgtcagccgccttgcgaaagaacacggggctttt
gatgccgtgaagtgcactcactgggcagaagggggaaagggcgccttagccctggctcaa
gccgtccagagagcagctcagtcacccagcagcttccagctcctttatgacctcaagctc
ccagttgaggataaaatcaggatcattgcacagaagatctacggggcagatgacattgaa
ctgctccccgaagctcagcacaaagcggaagtctacacaaagcagggctttgggaatctg
cccatctgcatggccaaaacacacttgtccttgtctcataatccggagcagaaaggtgcg
cccacaggctttgtcctgcccattcgtgacatccgtgccagcgttggggctggttttcta
taccccctcgtaggaacgatgaccacaatgcctggactccctacccgaccttgtttctat
gatattgatttggaccctgaaactgaacaagtgaatgggctgttttaa

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