Komagataella phaffii: PAS_chr4_0063
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Entry
PAS_chr4_0063 CDS
T01092
Name
(RefSeq) C-24(28) sterol reductase, catalyzes the final step in ergosterol biosynthesis
KO
K00223
Delta24(24(1))-sterol reductase [EC:
1.3.1.71
]
Organism
ppa
Komagataella phaffii
Pathway
ppa00100
Steroid biosynthesis
ppa01100
Metabolic pathways
ppa01110
Biosynthesis of secondary metabolites
Module
ppa_M00102
Ergocalciferol biosynthesis, FPP => ergosterol/ergocalciferol
Brite
KEGG Orthology (KO) [BR:
ppa00001
]
09100 Metabolism
09103 Lipid metabolism
00100 Steroid biosynthesis
PAS_chr4_0063
Enzymes [BR:
ppa01000
]
1. Oxidoreductases
1.3 Acting on the CH-CH group of donors
1.3.1 With NAD+ or NADP+ as acceptor
1.3.1.71 Delta24(241)-sterol reductase
PAS_chr4_0063
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Gene cluster
GFIT
Motif
Pfam:
ERG4_ERG24
Motif
Other DBs
NCBI-GeneID:
8201151
NCBI-ProteinID:
XP_002493468
UniProt:
C4R6R4
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Position
4:127078..128520
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AA seq
480 aa
AA seq
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MSKTKTDGTKVGKQAEPIENNIDKSSHLVDSSGTSRFLADKEIEYDFGGPIGVTAMMLGF
PLLMYYMWISAEFYHGALAWPEPDQSWPQFLAHLYQLFLDHGKPSPRAWRIFLTFFFTQM
LFYVTLPGIWTKGQPLNHLNRKQLPYYCNALASFYTSIAIAVVLHLTGLFKIYTIVDMFG
EIMTCAITLGFTISIALYVYTLTVSGDYHRMTGNHVYDMFMGAPLNPRVGIIDLKMFFEV
RLPWYTLFFLTLGLCAKQYEEYGYVSTQAWFMLLAHWLYANACSKGEELIVPTWDMAYEK
FGFMLIFWNIAGVPYTYSQCTLFLFYHDPQEYNWSTGYNVLLFTVLLAAYYFFDTGNAQK
NAFRKQMGGDVHIRKSFPFLPYQILKNPKYLKCSNGSVLLIDGWYKYARKIHYTADYIQC
LTWALACGGASVFPWFFPVFFLITLLHRADRDNAKCKKKYGADWDKYLKECPYQFLPWIY
NT seq
1443 nt
NT seq
+upstream
nt +downstream
nt
atgtctaaaacgaagacggatggcaccaaagttggtaaacaggctgagcctatagagaac
aacatagataagagctcccatttggtggattcatctggaaccagccgatttctcgcagat
aaggaaattgaatacgacttcggtgggccaattggtgtcactgctatgatgcttgggttt
cctttgctgatgtactacatgtggattagtgccgagttttaccacggggctcttgcttgg
cctgaaccagaccagtcatggccacaatttctggctcatttgtatcagctatttcttgat
catggtaagccaagtcctagagcttggagaattttcctcacattctttttcacacaaatg
ttgttctacgtgactcttccaggaatctggactaagggtcagccactgaaccatctcaat
agaaaacagctaccttattactgtaatgctttggcgtctttctatacgagtatcgccatt
gctgtggtgttgcatttaacaggtttattcaaaatttatactatcgttgacatgttcggt
gaaatcatgacatgtgctatcactttgggtttcaccatatccatcgctttgtacgtctat
acgttaaccgtgtcaggggattaccacaggatgactggaaatcacgtttacgatatgttc
atgggtgcacctttgaatcctcgtgtcggtatcattgacttaaagatgttcttcgaggtt
aggttaccatggtacacattgtttttcttgactttaggtctttgtgctaagcaatatgag
gaatacggctatgtgtccacccaagcatggtttatgctattggcccattggttatatgcg
aatgcctgttcaaagggtgaggagttgatagttcctacctgggatatggcatacgagaag
tttggattcatgttgatcttttggaatattgctggagtgccatatacctactctcaatgt
actctgtttcttttctaccatgatcctcaagaatataactggtccactggctacaacgta
cttcttttcactgttctgttagctgcttattacttctttgacactggaaatgctcaaaag
aatgcttttagaaaacaaatgggtggagatgttcatattagaaaaagtttccctttcctc
ccttaccagattttgaagaaccccaaatatttgaagtgttccaatggatctgtgctgctg
atagatggctggtataagtatgcaagaaagatacattatactgccgattacatccaatgt
ctgacctgggctttagcttgtggtggggcttctgtctttccatggtttttccctgtattt
ttcctgataaccctattacatagggctgatagggacaacgccaagtgcaaaaagaaatat
ggagctgattgggataaatacctaaaagaatgcccataccaatttttaccctggatttac
tag
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