KEGG   Perognathus longimembris pacificus (Pacific pocket mouse): 125363077
Entry
125363077         CDS       T08928                                 
Symbol
Mthfd1
Name
(RefSeq) C-1-tetrahydrofolate synthase, cytoplasmic isoform X1
  KO
K00288  methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase [EC:1.5.1.5 3.5.4.9 6.3.4.3]
Organism
plop  Perognathus longimembris pacificus (Pacific pocket mouse)
Pathway
plop00670  One carbon pool by folate
plop01100  Metabolic pathways
plop01240  Biosynthesis of cofactors
plop04981  Folate transport and metabolism
Module
plop_M00141  C1-unit interconversion, eukaryotes
Brite
KEGG Orthology (KO) [BR:plop00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    125363077 (Mthfd1)
 09150 Organismal Systems
  09154 Digestive system
   04981 Folate transport and metabolism
    125363077 (Mthfd1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:plop04147]
    125363077 (Mthfd1)
Enzymes [BR:plop01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.5  methylenetetrahydrofolate dehydrogenase (NADP+)
     125363077 (Mthfd1)
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.4  In cyclic amidines
    3.5.4.9  methenyltetrahydrofolate cyclohydrolase
     125363077 (Mthfd1)
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.4  Other carbon-nitrogen ligases
    6.3.4.3  formate---tetrahydrofolate ligase
     125363077 (Mthfd1)
Exosome [BR:plop04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   125363077 (Mthfd1)
SSDB
Motif
Pfam: FTHFS THF_DHG_CYH_C THF_DHG_CYH
Other DBs
NCBI-GeneID: 125363077
NCBI-ProteinID: XP_048218017
LinkDB
Position
14:33266919..33339583
AA seq 935 aa
MAPAEILDGKVVSAQIRASLKNQVTQMKEQVPGFIPCLAILQVGNRDDSNLYISAKLKAA
EEIGIKAFHVKLPRTATESEVLKQVTSLNEDSTVHGFIVQLPLDSENPINTEVIINAVAP
EKDVDGLTSISAGKLARGDLNDCFIPCTPKGCLELIKKTGVQIAGRHAVVVGRSKIVGAP
MHDLLLWNNATVTTCHSKTANLNEEVNKGDILVVATGQPEMVKGEWIKPGAVVIDCGINY
IPDHTKKSGKKVVGDVAYEEARTRAGFITPVPGGVGPMTVAMLMQSTVESAQRFLGKLKP
GKWTIQYNSLNLETPVPSDIDISRSCKPKPIGNLAREIGLLSEEVELYGETKAKVLLSAL
ERLKHQPDGKYVVVTGITPTPLGEGKSTTTIGLVQALGAHLHQNVFACVRQPSQGPTFGI
KGGAAGGGYSQVIPMEEFNLHLTGDIHAITAANNLVAAAIDARMFHELTQTDKALFNRLV
PSVNGVRKFSEIQIRRLWRLGIEKTDPTTLTDEEINKFARLDIDPETITWQRVLDTNDRF
LRKITIGQAPTEKGYTRTAQFDISVASEIMAVLALTSSLEDMRERLGKMVVASSKKGEPI
TAEDLGVSGALTVLMKDAIKPNLMQTLEGTPVFVHAGPFANIAHGNSSIIADRIALKLVG
PEGFVVTEAGFGADIGMEKFFNIKCRYSGLRPHVVVLVATVRALKMHGGGPTVTAGLPLP
KAYTEENLELVEKGFSNLRKQIENARMFGVPVVVATNAFKTDTEAELGLIGRLAREHGAF
DAVTCTHWAEGGKGAVALAQAVQRAAQAPSNFQLLYDLQLPVEDKIRIIAQKIYGADDIE
LLPEAQHKADVYTKQGFGNLPICMAKTHLSLSHDPEQKGVPTGFILPIRDIRASVGAGFL
YPLVGTMSTMPGLPTRPCFYDIDLDPETQQVNGLF
NT seq 2808 nt   +upstreamnt  +downstreamnt
atggcgccggcggaaatcctggacgggaaggtggtctccgcgcaaataagggcaagtctg
aagaaccaagtcactcagatgaaggagcaagtacctggctttataccctgcctggcaatt
ttgcaggttggcaacagagatgattccaatctttatataagtgcgaagctgaaggctgct
gaagagattgggatcaaagcctttcacgttaagttgccaagaacagccacagaatctgag
gtgttaaagcaggtcacatccttgaatgaggactccacagtgcatggattcatagtgcag
ctgcctttagattcagagaatcccattaacactgaagtgatcatcaatgctgttgcacct
gaaaaggatgtggatgggttaacaagtatcagtgctggcaaacttgctagaggtgatcta
aatgactgtttcattccttgtactcctaaaggatgtttggaactaatcaagaagacaggg
gtgcagattgctggaaggcatgctgtggtggttgggcgcagtaaaatagtcggtgccccc
atgcatgacttgctcctgtggaataatgctacagtgaccacctgccattcaaagactgcc
aatctgaatgaagaggtaaacaaaggtgatatcctggtggtggcaaccggccagcctgaa
atggtgaagggggagtggatcaagcctggggcagttgtcatcgactgtgggatcaattac
atcccagaccataccaaaaaaagtgggaagaaagttgtaggcgacgtggcgtatgaggag
gccagaaccagggcgggcttcatcactcccgtccctggcggcgtggggcccatgaccgtg
gcgatgctgatgcagagcacagtagagagtgcacagcgattcctggggaaattgaaacct
ggaaaatggacaatccagtataacagccttaacctggagacacctgttccaagtgacatt
gatatatcacgatcttgcaaaccaaagcccattggtaatttggctcgagaaattggtctg
ctctcggaagaggtggaattatatggtgaaacgaaggccaaagttctgctgtcagcactg
gaacgcctgaagcaccagcctgatgggaaatatgtggtggtgacaggaataaccccaaca
cccctgggagaaggaaaaagcacaaccaccatcgggctggtacaagccctcggggcccac
ctccatcagaatgtctttgcctgtgttcggcagccttctcaaggccccacctttggaata
aaaggtggcgctgcaggaggtggctattcccaggtcattcctatggaagagtttaatctc
cacctcactggtgacatccacgccatcactgcagctaacaacctcgtggctgcagccatt
gatgctcgaatgttccatgaactgactcagacagacaaggctctctttaatcgtctggtg
ccatcagtaaatggagtgagaaagttctctgagatccaaattcgaaggttatggagacta
ggcattgaaaaaacagaccctaccacattgacagatgaagagataaacaaatttgcaaga
ctggatattgacccagaaaccataacttggcaaagagtgttggataccaatgatagattc
ctgaggaagatcaccattggacaggctccgacagagaaaggatacacgcggacggcccag
tttgatatctctgtggccagtgaaatcatggctgtcctggctctcactagctctctggaa
gacatgagagagagactaggcaaaatggtcgtggcatccagtaagaaaggggagcccatc
actgctgaagatctgggggtgagcggtgcgctgacggtgctgatgaaggacgcaatcaag
cccaatctcatgcagacgttagagggcactccagtgtttgttcatgctggaccctttgcc
aacatcgcacatggcaattcctccatcattgcagaccggattgcactcaaacttgttggc
ccagaaggctttgtagtgactgaagcaggattcggagcagacattggaatggaaaaattc
tttaacatcaaatgccgctactccggactccgccctcacgttgtggtgcttgttgccact
gtcagggctcttaagatgcatgggggcggccccacggtcactgcgggactacctcttccc
aaggcttacacagaggagaatctggagctggttgaaaaaggcttcagtaatttgaggaaa
caaatcgaaaatgccagaatgtttggagttcctgtagtagtggccacaaatgcattcaag
actgatactgaggcagagctgggcctcatcggccgcctcgccagagagcatggggcattt
gatgcagtcacgtgcactcactgggctgaggggggtaagggggccgtcgccctggctcag
gctgtccagagagcggcacaggcgcccagcaacttccaactcctctatgaccttcagctc
ccagttgaggataaaatcaggatcattgcacagaagatctatggggcagatgacattgag
ttgctccctgaagctcagcacaaggctgacgtctacacaaagcagggctttgggaatcta
cccatctgcatggccaaaacacacttgtccttgtcccacgacccagagcaaaaaggtgtg
cctaccggcttcatcctgcccattcgggacatccgtgccagtgtcggggcgggtttcctg
taccctttagtaggaacgatgagcacaatgcctggtcttcctactcggccctgtttttat
gatattgacttggaccctgagactcaacaggtgaatgggctgttctaa

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