KEGG   Cutibacterium acnes 6609: TIB1ST10_06460
Entry
TIB1ST10_06460    CDS       T02065                                 
Symbol
kgd
Name
(GenBank) alpha-ketoglutarate decarboxylase
  KO
K01616  multifunctional 2-oxoglutarate metabolism enzyme [EC:2.2.1.5 4.1.1.71 1.2.4.2 2.3.1.61]
Organism
pcn  Cutibacterium acnes 6609
Pathway
pcn00020  Citrate cycle (TCA cycle)
pcn00630  Glyoxylate and dicarboxylate metabolism
pcn00785  Lipoic acid metabolism
pcn01100  Metabolic pathways
pcn01110  Biosynthesis of secondary metabolites
pcn01120  Microbial metabolism in diverse environments
pcn01200  Carbon metabolism
pcn01210  2-Oxocarboxylic acid metabolism
Module
pcn_M00009  Citrate cycle (TCA cycle, Krebs cycle)
pcn_M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
Brite
KEGG Orthology (KO) [BR:pcn00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00020 Citrate cycle (TCA cycle)
    TIB1ST10_06460 (kgd)
   00630 Glyoxylate and dicarboxylate metabolism
    TIB1ST10_06460 (kgd)
  09108 Metabolism of cofactors and vitamins
   00785 Lipoic acid metabolism
    TIB1ST10_06460 (kgd)
Enzymes [BR:pcn01000]
 1. Oxidoreductases
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.4  With a disulfide as acceptor
    1.2.4.2  oxoglutarate dehydrogenase (succinyl-transferring)
     TIB1ST10_06460 (kgd)
 2. Transferases
  2.2  Transferring aldehyde or ketonic groups
   2.2.1  Transketolases and transaldolases
    2.2.1.5  2-hydroxy-3-oxoadipate synthase
     TIB1ST10_06460 (kgd)
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.61  dihydrolipoyllysine-residue succinyltransferase
     TIB1ST10_06460 (kgd)
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.1  Carboxy-lyases
    4.1.1.71  2-oxoglutarate decarboxylase
     TIB1ST10_06460 (kgd)
SSDB
Motif
Pfam: E1_dh 2-oxoacid_dh Transket_pyr OxoGdeHyase_C 2-oxogl_dehyd_N
Other DBs
NCBI-ProteinID: AEH29585
LinkDB
Position
1366246..1369953
AA seq 1235 aa
MSPAPHDKSNNSPDFGANDWLIEEMRDQYQSDPNSVDPAWATFFRKEAVESTDSVTKSAA
KDVPGASAPKPATKPQPVPAAKPAPITAPKPQKQPPRPPMSADAPRHSAKLETVEPTVTK
MKGAPMRTAKNMDQSLTMPTATTVRDVPMQLVIEQRTMINSFLKKAKGGKVSFTHILAYA
MVQALKTVPAMNNAYAEIDGKPHLIENHQINLGMAIDVIASDGSRKLVVPAIKGAEQMDF
LDFWRAYEEIVRKGRTNELTVDDFKGVTASLTNPGGFGTNHSIARLMPGQGMILGVGSID
YPAAYQGNSPTRIAELGISKVTTLTSTYDHRIIQGAQSGEFLRRMHQLLLGADRFYEDIF
ESLRIPYAPVQWASDRLANRADQVGKQARVIELIDAWRRFGHLSADLDPIEYRPRFHRDL
MLNSHGLTLWDFDRTFPIANFAGQRRATMSLREILTILRDSYASKMGIEYMHIADYEQRK
WFQDRFEKEHQPLSRKMHLQILDQLNEAEIFETFLQTKFVGQKRFSLEGGESAIVLLAAL
CNRAADDGLNEVCIGMPHRGRLNVLANIIGKSYGQIFREFEGNAEPVNSQGSGDVKYHLG
DEGQFTAASGNTIKASVAANPSHLEAVDPVLEGICRAKLDALGNPEGFPVLPILMHGDAA
FAGQGVVYETLQMSQLGGYRTGGTIHVIVNNQVGFTTSPRDGRSSTYCTDVAKAVGAPVL
HVNGDDPASVVHAARIAYEYRQTFHRDVVVDVVCYRRRGHNEGDDPSFTQPHMYGLIAEK
RSTRKLYTESLIGRGDITTEDAEAVMTKFRSRLETVFKEVREATSTPEPYSGVPDYPVKH
SGLHQTKVEPDTMEAVARAHENLPESFNAHPKVAPQMTRRAKHIREGGIDWATGEMIALG
SLLRDGVHVRLAGQDSRRGTFSQRFAALVDHETGEFYVPVNHLGGEQAHLDVFDSPLNEY
AAMGFEYGYSVARPDSLVLWEAQFGDFTNGAQTIIDEFIASAGSKWGQKSGVVLLLPHGY
EGQGPDHSSARLERFLNLCSEDALAVCQPSTPASYSHLLRQHAYVNMHRPVVIATPKSML
RNKMATSDPEDFTTGRWRPVLPDPSITDPTAVTRIILCSGKARWELVKQRKATSLDGQLA
IIPMERLYPLPVDELAEVLAPYTNVTDVRWVQEEPENQGAWYYMLTHLPQAMSEKLPGFF
DGLVGITRPPSSAPSVGQHSVHIREEQELLEKAMA
NT seq 3708 nt   +upstreamnt  +downstreamnt
gtgagtcccgccccacacgacaagtccaacaactctcctgattttggagccaacgactgg
ctcatcgaagagatgcgtgaccagtatcagagtgatccgaattcggtcgatccggcctgg
gctacgttctttcgcaaggaggcagtcgagtccaccgactcggtgactaaatctgccgct
aaagatgtcccaggcgcgtcggcccccaagcctgcgacgaagccgcagcctgttcctgct
gcgaaacccgcgcccatcacagccccgaagccccaaaagcagcctccgcgtcctccaatg
tccgcagacgcaccgcgacatagcgccaagctcgagactgttgagccgacggtaacgaaa
atgaagggtgcgccgatgcgcaccgccaagaatatggatcagtcgctaaccatgccgacg
gccacgacggtacgtgacgtaccgatgcaattggtcatcgaacagcgcaccatgatcaac
tccttccttaagaaggccaaaggcggcaaggtttccttcacccatatcctggcttatgcc
atggtccaggccctcaaaacggtgcccgccatgaacaatgcatatgccgagattgacggt
aaaccgcacctcatcgaaaaccatcagatcaacctcggcatggccatcgacgtcattgcc
tcggatggatcgcgcaagctggttgtgcctgctatcaagggcgccgagcagatggacttc
cttgatttctggcgagcttatgaggagatcgtccggaaggggcgcactaatgagctgacc
gtcgacgatttcaagggggttaccgcctccctgacgaacccgggtggctttggcaccaat
cactccatcgctcgcctcatgcctggccagggcatgatcctcggggttggatcgattgac
tatcccgccgcctatcagggcaactcccctactcgaatagcggagttgggtatctccaag
gtgacgacgctcacctctacctatgaccatcgcatcatccagggtgctcagtccggagaa
ttcctgcgccgcatgcatcagttgttgctgggagctgaccgcttctatgaggacatcttc
gagtcactgcgcatcccctacgccccggttcagtgggcaagtgaccgtcttgctaatcgc
gctgatcaggtaggaaagcaagctcgcgtcatcgaactcatcgatgcgtggcgtcgtttc
ggacacctatcggctgatctcgatcccatcgagtaccggccgcggttccaccgcgacctc
atgctcaacagccacgggctgacgctgtgggacttcgaccgtaccttcccgatcgcgaac
ttcgctggtcagcgccgcgccacgatgtccttgcgcgagattctcacgatcttgcgtgac
tcgtacgcctcgaagatgggcatcgagtacatgcacatcgccgactatgagcagcgcaag
tggttccaggaccgtttcgagaaggagcatcagccgctctctcggaagatgcatttgcag
atcctcgaccaactcaacgaggccgagatctttgagaccttcttgcagaccaagttcgtc
ggtcagaagcgtttcagcctggaaggcggcgagtccgccatcgtcttgctggcagcccta
tgcaatcgcgcagctgacgatggtctcaacgaagtctgcatcggcatgccgcaccgtggc
cgtctcaatgtgctagccaacatcatcgggaaatcctacggacagatcttccgtgaattc
gagggcaatgccgagccggtgaattctcaggggtccggtgacgtcaagtaccacctcggt
gatgaaggccagttcaccgcagcctcgggtaacaccatcaaggcatctgtcgccgctaat
cccagccacctcgaggcagtcgatccggttctcgaaggtatctgccgtgccaagcttgac
gccctcggcaaccccgaaggtttcccggtactgcccattctcatgcacggtgacgctgcg
ttcgcgggtcagggtgtcgtctacgaaaccctgcagatgagccagcttgggggctaccgc
actggcggcaccattcacgtcatcgtcaacaatcaggttggctttaccacttccccgcgc
gacggtcgttcctcaacctactgcaccgatgtcgctaaggctgttggcgcaccggtcctc
cacgtcaacggagatgacccggcatcggtggtccacgcggctcgtatcgcctacgagtat
cgccagaccttccatcgcgatgtcgtcgttgacgtggtgtgctatcgccggcgcggccat
aacgagggtgacgatccgagcttcacacaaccgcacatgtacggcctcatcgctgaaaag
cgctcgacccgcaagctctacaccgagagcctcatcggtcgtggcgatatcactaccgag
gacgccgaggctgtgatgacaaagttccgctctcgtctggagacagtgttcaaggaggtt
cgcgaagccacctcgacgcctgagccctacagcggtgtgccagactacccggtcaagcac
agtggcctgcaccagaccaaggtcgagcctgacacaatggaggccgtcgccagggctcat
gagaatctgccagaaagcttcaatgctcaccccaaggtcgccccacagatgacacggcgc
gccaagcatatccgtgagggcggtattgactgggccaccggagagatgatcgcattgggt
tcccttctgcgtgatggcgtacacgtccgtctagccggtcaggacagccgccgcggcacc
ttctcccagcgttttgcggcgctggtagatcacgaaaccggtgagttctacgtcccggtt
aaccaccttggaggcgaacaggcgcacctcgacgtcttcgattctccgcttaacgagtac
gcagcgatgggatttgagtacggctactctgtcgcccgtccggattctctggtgctgtgg
gaagcccaattcggcgatttcaccaacggtgctcagacgatcattgatgagttcatcgcc
tcggctggctccaagtggggtcagaagtcgggagtcgtgctgctgctgccgcacggttac
gaaggtcaggggcctgatcactcatcggcccgtctggagcgcttcctcaatctatgcagt
gaagacgctttggccgtctgccagccctcgaccccggcaagctacagccatttattgcgt
cagcacgcgtacgtcaatatgcatcgtccagtcgttatcgcaacgccgaaatcgatgctg
cgcaacaagatggcgacctcggatcccgaagacttcaccaccggtaggtggcgtcctgtt
ctacccgacccatcgatcaccgacccgacggccgttacgaggattatcttgtgctctggc
aaggcgcggtgggagctagtcaagcaacgtaaggccaccagtcttgacggacagctcgcc
atcatcccgatggagcgtctctacccgctaccagtcgacgagttggctgaggttcttgcg
ccttacaccaacgtcacggatgtccgctgggtccaagaagagccagagaaccagggcgcc
tggtactacatgctgacccacctgccccaggccatgtcggagaagttgccaggattcttt
gatgggttagtcggcatcacccgcccaccgtcctcagctccgtcggtgggacagcacagc
gtccacatccgtgaagagcaggagttactcgagaaggctatggcctga

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