KEGG   PATHWAY: tmu00564
Entry
tmu00564                    Pathway                                
Name
Glycerophospholipid metabolism - Trichechus manatus latirostris (Florida manatee)
Class
Metabolism; Lipid metabolism
Pathway map
tmu00564  Glycerophospholipid metabolism
tmu00564

Module
tmu_M00090  Phosphatidylcholine (PC) biosynthesis, choline => PC [PATH:tmu00564]
tmu_M00091  Phosphatidylcholine (PC) biosynthesis, PE => PC [PATH:tmu00564]
Other DBs
GO: 0006650
Organism
Trichechus manatus latirostris (Florida manatee) [GN:tmu]
Gene
101359849  glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic isoform X2 [KO:K00006] [EC:1.1.1.8]
101342337  glycerol-3-phosphate dehydrogenase 1-like protein [KO:K00006] [EC:1.1.1.8]
101345370  glycerol-3-phosphate dehydrogenase 1-like protein [KO:K00006] [EC:1.1.1.8]
101355771  glycerol-3-phosphate dehydrogenase, mitochondrial isoform X1 [KO:K00111] [EC:1.1.5.3]
101346443  glycerol-3-phosphate acyltransferase 2, mitochondrial [KO:K00629] [EC:2.3.1.15]
101344208  glycerol-3-phosphate acyltransferase 1, mitochondrial [KO:K00629] [EC:2.3.1.15]
101349557  glycerol-3-phosphate acyltransferase 4 isoform X1 [KO:K13506] [EC:2.3.1.15]
101346450  glycerol-3-phosphate acyltransferase 3 [KO:K13506] [EC:2.3.1.15]
101353727  1-acyl-sn-glycerol-3-phosphate acyltransferase alpha [KO:K13509] [EC:2.3.1.51]
101348310  1-acyl-sn-glycerol-3-phosphate acyltransferase beta [KO:K13509] [EC:2.3.1.51]
101340934  1-acyl-sn-glycerol-3-phosphate acyltransferase delta [KO:K13523] [EC:2.3.1.51 2.3.1.-]
101350334  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X1 [KO:K13523] [EC:2.3.1.51 2.3.1.-]
101342307  1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon [KO:K19007] [EC:2.3.1.51]
101348093  lysocardiolipin acyltransferase 1 isoform X1 [KO:K13513] [EC:2.3.1.- 2.3.1.51]
101352185  lysophospholipid acyltransferase 2 isoform X1 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
101347101  lysophospholipid acyltransferase 1 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
101361755  dihydroxyacetone phosphate acyltransferase isoform X1 [KO:K00649] [EC:2.3.1.42]
101361939  manganese-dependent ADP-ribose/CDP-alcohol diphosphatase isoform X1 [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
101360105  phospholipid phosphatase 3 [KO:K01080] [EC:3.1.3.4]
101359980  phospholipid phosphatase 2 [KO:K01080] [EC:3.1.3.4]
101351341  phospholipid phosphatase 1 isoform X3 [KO:K01080] [EC:3.1.3.4]
101350425  phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
101359075  phosphatidate phosphatase LPIN3 [KO:K15728] [EC:3.1.3.4]
101344704  phosphatidate phosphatase LPIN1 [KO:K15728] [EC:3.1.3.4]
101356541  phospholipid phosphatase 4 isoform X1 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
101340844  phospholipid phosphatase 5 isoform X1 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
101343024  diacylglycerol kinase theta [KO:K00901] [EC:2.7.1.107]
101344384  diacylglycerol kinase epsilon [KO:K00901] [EC:2.7.1.107]
101342673  diacylglycerol kinase eta [KO:K00901] [EC:2.7.1.107]
101356932  diacylglycerol kinase delta [KO:K00901] [EC:2.7.1.107]
101351610  diacylglycerol kinase gamma [KO:K00901] [EC:2.7.1.107]
101344334  diacylglycerol kinase zeta isoform X1 [KO:K00901] [EC:2.7.1.107]
101357484  diacylglycerol kinase iota [KO:K00901] [EC:2.7.1.107]
101356641  diacylglycerol kinase alpha isoform X4 [KO:K00901] [EC:2.7.1.107]
101348600  diacylglycerol kinase beta isoform X4 [KO:K00901] [EC:2.7.1.107]
101360133  cholinephosphotransferase 1 [KO:K00994] [EC:2.7.8.2]
101355451  choline/ethanolaminephosphotransferase 1 [KO:K13644] [EC:2.7.8.1 2.7.8.2]
101346935  sphingomyelin synthase-related protein 1 isoform X2 [KO:K22697] [EC:3.1.4.62]
101353208  phosphatidylcholine:ceramide cholinephosphotransferase 1 [KO:K04714] [EC:2.7.8.27 3.1.4.62]
101344228  phosphatidylcholine:ceramide cholinephosphotransferase 2 [KO:K04714] [EC:2.7.8.27 3.1.4.62]
101343866  phospholipase D2 [KO:K01115] [EC:3.1.4.4]
101358169  phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
101353655  phospholipase D4 [KO:K16860] [EC:3.1.4.4]
101355584  phospholipase D3 [KO:K16860] [EC:3.1.4.4]
101354314  phosphatidylcholine-sterol acyltransferase [KO:K00650] [EC:2.3.1.43]
101357063  group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
101340958  group 10 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101350719  putative inactive group IIC secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101350972  group IIF secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101351238  calcium-dependent phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101351497  phospholipase A2, membrane associated [KO:K01047] [EC:3.1.1.4]
101359028  phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101345796  phospholipase A2, membrane associated-like [KO:K01047] [EC:3.1.1.4]
101346575  group IID secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101346825  group IIE secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101348013  group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101358673  group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101345270  cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
101354943  cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
101355199  cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
101352550  cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
101353066  cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
101345872  85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
101361095  LOW QUALITY PROTEIN: phospholipase B1, membrane-associated [KO:K14621] [EC:3.1.1.4 3.1.1.5]
101358172  HRAS-like suppressor 3 isoform X1 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
101358559  lysophosphatidylcholine acyltransferase 2 isoform X1 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
101356728  lysophosphatidylcholine acyltransferase 2B-like [KO:K13510] [EC:2.3.1.23 2.3.1.67]
101340988  lysophosphatidylcholine acyltransferase 1 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
101359114  lysophospholipid acyltransferase LPCAT4 [KO:K13512] [EC:2.3.1.23 2.3.1.-]
101358882  lysophospholipid acyltransferase 5 isoform X1 [KO:K13515] [EC:2.3.1.23 2.3.1.-]
101348848  acyl-protein thioesterase 1 isoform X2 [KO:K06128] [EC:3.1.1.5]
101351919  group XV phospholipase A2 isoform X1 [KO:K06129] [EC:3.1.1.5]
101356043  acyl-protein thioesterase 2 [KO:K06130] [EC:3.1.1.5]
101344222  neuropathy target esterase isoform X2 [KO:K14676] [EC:3.1.1.5]
101352694  patatin-like phospholipase domain-containing protein 7 [KO:K14676] [EC:3.1.1.5]
101350480  glycerophosphocholine phosphodiesterase GPCPD1 isoform X1 [KO:K18695] [EC:3.1.4.2]
101347293  choline O-acetyltransferase [KO:K00623] [EC:2.3.1.6]
101347790  acetylcholinesterase isoform X1 [KO:K01049] [EC:3.1.1.7]
101354593  choline/ethanolamine kinase isoform X2 [KO:K14156] [EC:2.7.1.32 2.7.1.82]
101340480  choline kinase alpha isoform X1 [KO:K14156] [EC:2.7.1.32 2.7.1.82]
101359892  phosphoethanolamine/phosphocholine phosphatase isoform X1 [KO:K06124] [EC:3.1.3.75]
101357456  choline-phosphate cytidylyltransferase A [KO:K00968] [EC:2.7.7.15]
101358080  choline-phosphate cytidylyltransferase B [KO:K00968] [EC:2.7.7.15]
101358495  ethanolaminephosphotransferase 1 [KO:K00993] [EC:2.7.8.1]
101345734  ethanolamine kinase 1 [KO:K00894] [EC:2.7.1.82]
101354670  ethanolamine kinase 2 isoform X1 [KO:K00894] [EC:2.7.1.82]
101346588  LOW QUALITY PROTEIN: ethanolamine-phosphate phospho-lyase [KO:K14286] [EC:4.2.3.2]
101353252  phosphatidylethanolamine N-methyltransferase isoform X2 [KO:K00551] [EC:2.1.1.17 2.1.1.71]
101349977  phosphatidate cytidylyltransferase 2 [KO:K00981] [EC:2.7.7.41]
101345682  phosphatidate cytidylyltransferase 1 [KO:K00981] [EC:2.7.7.41]
101349358  phospholipase A1 member A [KO:K13618] [EC:3.1.1.111]
101360204  phosphatidylserine synthase 1 [KO:K08729] [EC:2.7.8.-]
101351025  phosphatidylserine synthase 2 [KO:K08730] [EC:2.7.8.29]
101347600  phosphatidylserine decarboxylase proenzyme, mitochondrial isoform X1 [KO:K01613] [EC:4.1.1.65]
101348164  CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial isoform X2 [KO:K00995] [EC:2.7.8.5]
101360345  LOW QUALITY PROTEIN: cardiolipin synthase (CMP-forming) [KO:K08744] [EC:2.7.8.41]
101345086  tafazzin isoform X2 [KO:K13511] [EC:2.3.1.-]
101355301  acyl-CoA:lysophosphatidylglycerol acyltransferase 1 [KO:K13514] [EC:2.3.1.-]
101346778  CDP-diacylglycerol--inositol 3-phosphatidyltransferase [KO:K00999] [EC:2.7.8.11]
101352553  lysophospholipid acyltransferase 7 isoform X1 [KO:K13516] [EC:2.3.1.-]
Compound
C00040  Acyl-CoA
C00065  L-Serine
C00084  Acetaldehyde
C00093  sn-Glycerol 3-phosphate
C00111  Glycerone phosphate
C00114  Choline
C00157  Phosphatidylcholine
C00189  Ethanolamine
C00269  CDP-diacylglycerol
C00307  CDP-choline
C00344  Phosphatidylglycerol
C00346  Ethanolamine phosphate
C00350  Phosphatidylethanolamine
C00416  Phosphatidate
C00513  CDP-glycerol
C00570  CDP-ethanolamine
C00588  Choline phosphate
C00623  sn-Glycerol 1-phosphate
C00641  1,2-Diacyl-sn-glycerol
C00670  sn-Glycero-3-phosphocholine
C00681  1-Acyl-sn-glycerol 3-phosphate
C01194  1-Phosphatidyl-D-myo-inositol
C01210  N-Methylethanolamine phosphate
C01233  sn-Glycero-3-phosphoethanolamine
C01241  Phosphatidyl-N-methylethanolamine
C01996  Acetylcholine
C02737  Phosphatidylserine
C03372  Acylglycerone phosphate
C03819  1-Acylglycerophosphoinositol
C03872  L-Serine-phosphoethanolamine
C03892  Phosphatidylglycerophosphate
C03974  2-Acyl-sn-glycerol 3-phosphate
C04230  1-Acyl-sn-glycero-3-phosphocholine
C04233  2-Acyl-sn-glycero-3-phosphocholine
C04308  Phosphatidyl-N-dimethylethanolamine
C04438  1-Acyl-sn-glycero-3-phosphoethanolamine
C04590  3-(O-Geranylgeranyl)-sn-glycerol 1-phosphate
C04638  2,3-Bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate
C05973  2-Acyl-sn-glycero-3-phosphoethanolamine
C05974  2-Acyl-sn-glycero-3-phosphoserine
C05976  Aminoacyl-phosphatidylglycerol
C05980  Cardiolipin
C06771  Triethanolamine
C06772  Diethanolamine
C13482  Phosphodimethylethanolamine
C18059  CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol
C18125  1-Acyl-sn-glycero-3-phosphoserine
C18126  1-Acyl-sn-glycero-3-phosphoglycerol
C18129  Monolysocardiolipin
C18168  Diacylglycerylhomoserine
C18169  Diacylglyceryl-N,N,N-trimethylhomoserine
C20466  2,3-Bis-(O-geranylgeranyl)-sn-glycero-1-phospho-L-serine
C20518  2,3-Bis-(O-phytanyl)-sn-glycerol 1-phosphate
C22340  Heptaprenylglyceryl phosphate
C22341  Heptaprenylglycerol
C22342  Diacetylheptaprenylglycerol
Reference
PMID:1512203
  Authors
Racenis PV, Lai JL, Das AK, Mullick PC, Hajra AK, Greenberg ML.
  Title
The acyl dihydroxyacetone phosphate pathway enzymes for glycerolipid biosynthesis are present in the yeast Saccharomyces cerevisiae.
  Journal
J Bacteriol 174:5702-10 (1992)
DOI:10.1128/JB.174.17.5702-5710.1992
Reference
PMID:10092508
  Authors
Taniyama Y, Shibata S, Kita S, Horikoshi K, Fuse H, Shirafuji H, Sumino Y, Fujino M.
  Title
Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase.
  Journal
Biochem Biophys Res Commun 257:50-6 (1999)
DOI:10.1006/bbrc.1999.0411
Reference
PMID:10542045
  Authors
Athenstaedt K, Daum G.
  Title
Phosphatidic acid, a key intermediate in lipid metabolism.
  Journal
Eur J Biochem 266:1-16 (1999)
DOI:10.1046/j.1432-1327.1999.00822.x
Reference
PMID:12431977
  Authors
Shields DJ, Lehner R, Agellon LB, Vance DE.
  Title
Membrane topography of human phosphatidylethanolamine N-methyltransferase.
  Journal
J Biol Chem 278:2956-62 (2003)
DOI:10.1074/jbc.M210904200
Reference
PMID:14663079
  Authors
Martinez-Morales F, Schobert M, Lopez-Lara IM, Geiger O.
  Title
Pathways for phosphatidylcholine biosynthesis in bacteria.
  Journal
Microbiology 149:3461-71 (2003)
DOI:10.1099/mic.0.26522-0
Reference
PMID:15522832
  Authors
Burgermeister M, Birner-Grunberger R, Nebauer R, Daum G.
  Title
Contribution of different pathways to the supply of phosphatidylethanolamine and phosphatidylcholine to mitochondrial membranes of the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1686:161-8 (2004)
DOI:10.1016/j.bbalip.2004.09.007
Reference
PMID:1649829
  Authors
Hsu L, Jackowski S, Rock CO
  Title
Isolation and characterization of Escherichia coli K-12 mutants lacking both 2-acyl-glycerophosphoethanolamine acyltransferase and acyl-acyl carrier protein synthetase activity.
  Journal
J Biol Chem 266:13783-8 (1991)
Reference
PMID:10938271
  Authors
Stone SJ, Vance JE.
  Title
Phosphatidylserine synthase-1 and -2 are localized to mitochondria-associated membranes.
  Journal
J Biol Chem 275:34534-40 (2000)
DOI:10.1074/jbc.M002865200
Related
pathway
tmu00010  Glycolysis / Gluconeogenesis
tmu00260  Glycine, serine and threonine metabolism
tmu00561  Glycerolipid metabolism
tmu00562  Inositol phosphate metabolism
tmu00563  Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
tmu00565  Ether lipid metabolism
tmu00620  Pyruvate metabolism
KO pathway
ko00564   
LinkDB

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