KEGG   PATHWAY: pgd04981
Entry
pgd04981                    Pathway                                
Name
Folate transport and metabolism - Phaeobacter gallaeciensis DSM 26640
Class
Organismal Systems; Digestive system
Pathway map
pgd04981  Folate transport and metabolism
pgd04981

Organism
Phaeobacter gallaeciensis DSM 26640 [GN:pgd]
Gene
Gal_01217  5-formyltetrahydrofolate cyclo-ligase [KO:K01934] [EC:6.3.3.2]
Gal_01285  Dihydrofolate reductase [KO:K00287] [EC:1.5.1.3]
Gal_00934  Glycine/serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
Gal_02218  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
Gal_01284  thymidylate synthase [KO:K00560] [EC:2.1.1.45]
Gal_01739  Pterin binding protein enzyme [KO:K00548] [EC:2.1.1.13]
Gal_02067  Methionine synthase I (cobalamin-dependent), methyltransferase domain protein [KO:K00548] [EC:2.1.1.13]
Compound
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00073  L-Methionine
C00080  H+
C00101  Tetrahydrofolate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00155  L-Homocysteine
C00157  Phosphatidylcholine
C00364  dTMP
C00365  dUMP
C00415  Dihydrofolate
C00440  5-Methyltetrahydrofolate
C00445  5,10-Methenyltetrahydrofolate
C00504  Folate
C00719  Betaine
C01026  N,N-Dimethylglycine
C01937  Methotrexate
C01996  Acetylcholine
C03479  Folinic acid
Reference
  Authors
Alam C, Kondo M, O'Connor DL, Bendayan R
  Title
Clinical Implications of Folate Transport in the Central Nervous System.
  Journal
Trends Pharmacol Sci 41:349-361 (2020)
DOI:10.1016/j.tips.2020.02.004
Reference
  Authors
Akiyama T, Kuki I, Kim K, Yamamoto N, Yamada Y, Igarashi K, Ishihara T, Hatano Y, Kobayashi K
  Title
Folic acid inhibits 5-methyltetrahydrofolate transport across the blood-cerebrospinal fluid barrier: Clinical biochemical data from two cases.
  Journal
JIMD Rep 63:529-535 (2022)
DOI:10.1002/jmd2.12321
Reference
  Authors
Visentin M, Diop-Bove N, Zhao R, Goldman ID
  Title
The intestinal absorption of folates.
  Journal
Annu Rev Physiol 76:251-74 (2014)
DOI:10.1146/annurev-physiol-020911-153251
Reference
  Authors
Ledowsky C, Mahimbo A, Scarf V, Steel A
  Title
Women Taking a Folic Acid Supplement in Countries with Mandatory Food Fortification Programs May Be Exceeding the Upper Tolerable Limit of Folic Acid:  A Systematic Review.
  Journal
Nutrients 14:nu14132715 (2022)
DOI:10.3390/nu14132715
Reference
  Authors
Zarou MM, Vazquez A, Vignir Helgason G
  Title
Folate metabolism: a re-emerging therapeutic target in haematological cancers.
  Journal
Leukemia 35:1539-1551 (2021)
DOI:10.1038/s41375-021-01189-2
Reference
  Authors
Bekdash RA
  Title
Methyl Donors, Epigenetic Alterations, and Brain Health: Understanding the Connection.
  Journal
Int J Mol Sci 24:ijms24032346 (2023)
DOI:10.3390/ijms24032346
Reference
  Authors
Steinfeld R, Grapp M, Kraetzner R, Dreha-Kulaczewski S, Helms G, Dechent P, Wevers R, Grosso S, Gartner J
  Title
Folate receptor alpha defect causes cerebral folate transport deficiency: a treatable neurodegenerative disorder associated with disturbed myelin metabolism.
  Journal
Am J Hum Genet 85:354-63 (2009)
DOI:10.1016/j.ajhg.2009.08.005
Reference
  Authors
Sternbach S, West N, Singhal NK, Clements R, Basu S, Tripathi A, Dutta R, Freeman EJ, McDonough J
  Title
The BHMT-betaine methylation pathway epigenetically modulates oligodendrocyte maturation.
  Journal
PLoS One 16:e0250486 (2021)
DOI:10.1371/journal.pone.0250486
Reference
  Authors
Shulpekova Y, Nechaev V, Kardasheva S, Sedova A, Kurbatova A, Bueverova E, Kopylov A, Malsagova K, Dlamini JC, Ivashkin V
  Title
The Concept of Folic Acid in Health and Disease.
  Journal
Molecules 26:molecules26123731 (2021)
DOI:10.3390/molecules26123731
Reference
  Authors
Mafi S, Laroche-Raynaud C, Chazelas P, Lia AS, Derouault P, Sturtz F, Baaj Y, Froget R, Rio M, Benoist JF, Poumeaud F, Favreau F, Faye PA
  Title
Pharmacoresistant Epilepsy in Childhood: Think of the Cerebral Folate Deficiency, a Treatable Disease.
  Journal
Brain Sci 10:brainsci10110762 (2020)
DOI:10.3390/brainsci10110762
Related
pathway
pgd00240  Pyrimidine metabolism
pgd00670  One carbon pool by folate
KO pathway
ko04981   
LinkDB

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