KEGG   PATHWAY: pdr01210
Entry
pdr01210                    Pathway                                
Name
2-Oxocarboxylic acid metabolism - Pseudomonas sp. ATCC 13867
Description
2-Oxocarboxylic acids, also called 2-oxo acids and alpha-keto acids, are the most elementary set of metabolites that includes pyruvate (2-oxopropanoate), 2-oxobutanoate, oxaloacetate (2-oxosuccinate) and 2-oxoglutarate. This diagram illustrates the architecture of chain extension and modification reaction modules for 2-oxocarboxylic acids. The chain extension module RM001 is a tricarboxylic pathway where acetyl-CoA derived carbon is used to extend the chain length by one. The chain modification modules RM002 (including RM032) and RM033, together with a reductive amination step (RC00006 or RC00036), generate basic and branched-chain amino acids, respectively. The modification module RM030 is used in the biosynthesis of glucosinolates, a class of plant secondary metabolites, for conversion to oxime followed by addition of thio-glucose moiety. Furthermore, the chain extension from 2-oxoadipate to 2-oxosuberate is followed by coenzyme B biosynthesis in methonogenic archaea.
Class
Pathway map
pdr01210  2-Oxocarboxylic acid metabolism
pdr01210

Module
pdr_M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate [PATH:pdr01210]
pdr_M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate [PATH:pdr01210]
pdr_M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:pdr01210]
pdr_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:pdr01210]
pdr_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:pdr01210]
Organism
Pseudomonas sp. ATCC 13867 [GN:pdr]
Related
pathway
pdr00020  Citrate cycle (TCA cycle)
pdr00220  Arginine biosynthesis
pdr00250  Alanine, aspartate and glutamate metabolism
pdr00260  Glycine, serine and threonine metabolism
pdr00270  Cysteine and methionine metabolism
pdr00290  Valine, leucine and isoleucine biosynthesis
pdr00300  Lysine biosynthesis
pdr00310  Lysine degradation
pdr00620  Pyruvate metabolism
pdr00640  Propanoate metabolism
pdr00680  Methane metabolism
KO pathway
ko01210   
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