Entry Name Biosynthesis of various antibiotics
Including Kanosamine biosynthesis, Aurachin biosynthesis, Bacilysin biosynthesis, Puromycin biosynthesis, Dapdiamides biosynthesis, Fosfomycin biosynthesis, Cremeomycin biosynthesis, Fumagillin biosynthesis, Pentalenolactone biosynthesis, Terpentecin biosynthesis, Roseoflavin biosynthesis, Cycloserine biosynthesis
Class Metabolism; Biosynthesis of other secondary metabolitesBRITE hierarchy
Pathway map map00998 Biosynthesis of various antibiotics
Ortholog table Module M00785 Cycloserine biosynthesis, arginine/serine => cycloserine [PATH:map00998 ]
M00787 Bacilysin biosynthesis, prephenate => bacilysin [PATH:map00998 ]
M00819 Pentalenolactone biosynthesis, farnesyl-PP => pentalenolactone [PATH:map00998 ]
M00848 Aurachin biosynthesis, anthranilate => aurachin A [PATH:map00998 ]
M00877 Kanosamine biosynthesis, glucose 6-phosphate => kanosamine [PATH:map00998 ]
M00903 Fosfomycin biosynthesis, phosphoenolpyruvate => fosfomycin [PATH:map00998 ]
M00904 Dapdiamides biosynthesis, L-2,3-diaminopropanoate => dapdiamide A/B/C [PATH:map00998 ]
M00951 Cremeomycin biosynthesis, aspartate/3,4-AHBA => cremeomycin [PATH:map00998 ]
M00969 Fumagillin biosynthesis, farnesyl-PP => fumagillin [PATH:map00998 ]
Drug Reference Authors Sandmann A, Dickschat J, Jenke-Kodama H, Kunze B, Dittmann E, Muller R
Title A Type II polyketide synthase from the gram-negative Bacterium Stigmatella aurantiaca is involved in Aurachin alkaloid biosynthesis.
Journal Reference Authors Vetter ND, Langill DM, Anjum S, Boisvert-Martel J, Jagdhane RC, Omene E, Zheng H, van Straaten KE, Asiamah I, Krol ES, Sanders DA, Palmer DR
Title A previously unrecognized kanosamine biosynthesis pathway in Bacillus subtilis.
Journal Reference Authors Ozcengiz G, Ogulur I
Title Biochemistry, genetics and regulation of bacilysin biosynthesis and its significance more than an antibiotic.
Journal Reference Authors Tercero JA, Espinosa JC, Lacalle RA, Jimenez A.
Title The biosynthetic pathway of the aminonucleoside antibiotic puromycin, as deduced from the molecular analysis of the pur cluster of Streptomyces alboniger.
Journal Reference Authors Hollenhorst MA, Clardy J, Walsh CT
Title The ATP-dependent amide ligases DdaG and DdaF assemble the fumaramoyl-dipeptide scaffold of the dapdiamide antibiotics.
Journal Reference Authors Schwarz J, Konjik V, Jankowitsch F, Sandhoff R, Mack M
Title Identification of the Key Enzyme of Roseoflavin Biosynthesis.
Journal Reference Authors Kumagai T, Koyama Y, Oda K, Noda M, Matoba Y, Sugiyama M
Title Molecular cloning and heterologous expression of a biosynthetic gene cluster for the antitubercular agent D-cycloserine produced by Streptomyces lavendulae.
Journal Reference Authors Hamano Y, Kuzuyama T, Itoh N, Furihata K, Seto H, Dairi T
Title Functional analysis of eubacterial diterpene cyclases responsible for biosynthesis of a diterpene antibiotic, terpentecin.
Journal Reference Authors Quaderer R, Omura S, Ikeda H, Cane DE
Title Pentalenolactone biosynthesis. Molecular cloning and assignment of biochemical function to PtlI, a cytochrome P450 of Streptomyces avermitilis.
Journal Reference Authors Hidaka T, Goda M, Kuzuyama T, Takei N, Hidaka M, Seto H
Title Cloning and nucleotide sequence of fosfomycin biosynthetic genes of Streptomyces wedmorensis.
Journal Reference Authors Lin HC, Tsunematsu Y, Dhingra S, Xu W, Fukutomi M, Chooi YH, Cane DE, Calvo AM, Watanabe K, Tang Y
Title Generation of complexity in fungal terpene biosynthesis: discovery of a multifunctional cytochrome P450 in the fumagillin pathway.
Journal Related map00250 Alanine, aspartate and glutamate metabolism
map00260 Glycine, serine and threonine metabolism
map00400 Phenylalanine, tyrosine and tryptophan biosynthesis
map00440 Phosphonate and phosphinate metabolism
map00900 Terpenoid backbone biosynthesis
KO pathway LinkDB All DBs
