KEGG   Ochotona princeps (American pika): 101523838
Entry
101523838         CDS       T07609                                 
Symbol
ALK
Name
(RefSeq) ALK tyrosine kinase receptor
  KO
K05119  anaplastic lymphoma kinase [EC:2.7.10.1]
Organism
opi  Ochotona princeps (American pika)
Pathway
opi05200  Pathways in cancer
opi05223  Non-small cell lung cancer
opi05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:opi00001]
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101523838 (ALK)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    101523838 (ALK)
  09162 Cancer: specific types
   05223 Non-small cell lung cancer
    101523838 (ALK)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:opi01001]
    101523838 (ALK)
  09183 Protein families: signaling and cellular processes
   04090 CD molecules [BR:opi04090]
    101523838 (ALK)
Enzymes [BR:opi01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     101523838 (ALK)
Protein kinases [BR:opi01001]
 Receptor tyrosine kinases (RTK)
  ALK family
   101523838 (ALK)
CD molecules [BR:opi04090]
 Proteins
  101523838 (ALK)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase MAM ALK_LTK_GRD FXa_inhibition
Other DBs
NCBI-GeneID: 101523838
NCBI-ProteinID: XP_004582764
LinkDB
Position
2:complement(22270477..22999302)
AA seq 1624 aa
MQPSSGGMRAIGLLWLLLLLLSAAASGSGAAAGQHAGTPAMGPPLQPREPLSYSRLQRKS
LAVDFVVPSLFRAYVRDLLLPQEPRAGLTEARGVLALDCAPLLRLLGPPSGVSWASPVPA
LSRVLKGGSVRKLRRAKQLVLELGEESILEGCLGPPEEAAAGLLQFNLSELFSWWIRHGE
GRLRIRLMPEKKASEGGREGRLSTAIRASQPRLLFQILGAGASSLESPTHMPSLPPDYFS
WNLTWTMKDSFPFLSHRSRYGLECSFDFPCELEYFPPLHDRGNQSWSWRRVPPEEASQMD
FLDGPEAERAKDMPRGSFLLLNTSAESKHTILSPWMRSSSEHCTLAVSVHRHLQPTGRYV
AQLLPHNEPGREILLVPTPGKHGWTVLQGRVGRPEHPFRVALEYISSGNRSLSAVDFFAL
KNCSEGTSPGSKMALQSSFTCWNATVLRLGQACDFHQDCSQGEDEGHLCSKLPTGFYCNF
EDGLCGWTQDTLSSQGPRWQVRTMKDARSQGHQDHALLLSTTEVATSESATVTSATFPAP
MKNSPCELRMAWLVRGVLRGNVSLLLVENKTGKEQSRMLWHVPPSNGLSLWQWVVLPLLD
VSDRFWLQMVAWWGQGSRATVAFDNISISLDCYLTISGEDKMPPNAEPKSRNLFEGISNK
DLKPREPTPGTPTFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNQSVVVGSEGPLKGI
QIWTVPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDTLYILVGQQGEDAC
PSTNQLIQKVCIGENKVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLIIAAG
GGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWSDNTSLLWAGKSLLEGATGG
HSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGISFISPLG
ILYTPALKVMEGHGEVNIKHYLNCSHCEIDECHMDPETHKVICFCDHGTVLAQDGVSCIV
SPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQLELQSPEYKLSKL
RTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPSDPS
PLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQALPRFILLELMAGGD
LKSFLRETRPRPNQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGTG
RVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIF
SLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERI
EYCTQDPDVINTALPIEYGPLVEEEEKVPMRPKDPEGVPPLLVSPAQATREEVPAPAAPP
ALPATSSGRVAKKPAAAEVPARGPRGSAMEGGHVNMAFAQSTVPSELPKGQASRNKPTSL
WNPTYGSWFTEKPARKNNALAKKEPQDRGHPGQEGSCTVPPGGGGSGGVAPGRLPGGSLL
LEPAALTASMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAAAGPGAGRYEDPMLKAKGSGK
QPGP
NT seq 4875 nt   +upstreamnt  +downstreamnt
atgcagccctcctccggcgggatgcgagccatcgggctcctgtggctgttgctgctgctg
ctctcggcggcagcctcgggctctggggccgctgctggccagcacgcgggcaccccggcc
atggggccgccactgcagccccgggagccgctcagctactcgcgcctgcagaggaagagc
ctggccgtggacttcgtggtgccctcgctcttccgcgcctacgtcagggacctgctgctg
cctcaggagcccagggcgggcctgaccgaggcgcgtggcgtcctggccctggactgcgcc
ccgctgctgaggctgctggggccgccgtctggggtgtcctgggcatccccggtcccggcg
ctgtccagagtgctgaagggcggctctgtgcgcaagctccggcgcgccaagcagctggtg
ctggagctgggcgaggagtcgatcctggagggctgcctggggcctccagaggaggcggcc
gctggactgctccagttcaacctcagcgagctgttcagctggtggattcgccacggcgag
gggcggctgaggatccgcctgatgcccgagaagaaggcgtcggaagggggcagagaagga
aggctgtccacagccatccgcgcttcccagccacgccttctcttccagatccttggcgct
ggtgccagctccttggaatcaccaacacacatgccttctcttcctcccgactacttctcg
tggaatctgacctggacaatgaaagattccttccctttcctgtctcatcgaagccgatat
ggtctggagtgcagctttgatttcccctgcgagctggagtacttccctcccctgcatgac
cgcgggaaccagagctggtcgtggcgccgtgtaccacctgaggaggcatcccagatggac
tttctggatggacccgaggcagagcgcgccaaggacatgcccagaggctccttcctcctc
ctcaacacctcagctgaatccaagcacaccatcctgagcccctggatgagaagcagcagt
gagcactgcacgctggccgtctcggtacacaggcacctacagcccacagggaggtatgtg
gcccagctgctgccccacaacgagcctggaagagagatcctcctggtgcccactccaggg
aagcatggctggaccgtgctgcagggaagagtcgggcgcccagagcacccattccgagtg
gccctggaatacatctccagcgggaaccgaagcctgtctgcagtggacttcttcgccctg
aagaactgcagtgaaggaacgtccccgggctccaagatggcattacagagttccttcact
tgttggaatgcgacagtactccggctcgggcaggcctgtgacttccaccaggactgctcc
cagggagaagacgagggccacctgtgcagtaaactccctactggcttttactgcaacttt
gaagatgggttgtgtggctggacccaagacacactctcctcccagggacctcggtggcag
gtcaggaccatgaaggatgcccggtcccagggccaccaagatcatgccctgctgctcagc
accaccgaggtcgccacatctgagagcgctaccgtgaccagtgctacattcccagcacca
atgaagaattctccatgtgagctccgaatggcctggctcgtccgcggagtcctgagggga
aacgtgtccttgctgctagtggagaacaagaccgggaaggaacaaagcaggatgctctgg
catgttcctcccagcaatggcctgagcctgtggcagtgggtagtgttaccactcctcgac
gtgtctgacaggttctggctccaaatggtcgcgtggtggggacaaggatccagagccaca
gtggccttcgacaacatctccatcagcttggactgctacctcaccatcagcggagaagac
aaaatgccaccgaatgcagagcccaagtcaagaaatctgtttgaggggatctcaaacaag
gacttgaaacccagagaacctacacctgggacccccacctttgaccctacagttcactgg
ctgttcaccacgtgcggggccagcggacctcatggccccacgcaggcccagtgcaacaac
gcctatcagaactccaaccagagtgtggtggtgggaagcgaaggccccctgaaaggcatc
cagatctggacagtgccggccaccgacacttacagcatttcaggctatggagccgctggc
ggcaaaggcggaaagaacaccatgatgcggtcccatggtgtgtctgtgctgggcatcttc
aacttggagaaggacgacacgctctacatactggtcgggcagcagggcgaggatgcctgt
cccagcacaaaccagttaattcagaaagtctgcatcggtgagaacaaggtgatcgaggag
gagatccgtgtgaacagaagtgtgcacgagtgggcaggaggaggcggcggaggtggagga
gccacctatgtctttaagatgaaggatggagtgcccgtgccgctgatcattgcggctggc
ggtggcggcagagcctatggggccaagacagacacattccacccggagaggctcgagaac
aactcctcggtcctggggctaaacggcaattccggagccgcaggtggcggaggtggctgg
agtgataacacttccttgctctgggccggaaagtctttgctggagggtgccaccggagga
cattcctgcccccaggccatgaagaagtgggggtgggagacaagagggggtttcggaggg
ggtggaggggggtgctcctcaggtggaggaggcggaggatatataggcggcaacgcagcc
tcaaacaatgaccctgaaatggatggggaagatgggatttcctttatcagtccactgggc
atcctgtacaccccggctttgaaagtgatggagggccatggggaagtgaatattaagcat
tatctaaactgcagtcactgtgagatagacgagtgtcacatggaccccgagactcacaag
gtcatctgcttctgcgaccatggaacggtgctggcccaggatggtgtctcctgcattgtg
tcgcccaccccagagccccatctgccgctctcactgatcctctctgtggtcacctctgct
ctagtggccgcccttgtcctggctttctctggcatcatgattgtgtaccgtcgcaagcac
caggagctgcaggccatgcagctggagctgcagagccctgagtataagctgagcaagctc
cgcacctcgaccatcatgaccgactacaaccctaactactgcttcgccggcaagacctcc
tccatcagtgacctgaaggaggtgccacggaagaacatcaccctcatccggggtctgggc
catggtgcctttggggaagtatatgaaggccaggtgtctgggatgcccagcgacccaagc
cccctgcaagtggctgtcaagaccctgccggaggtgtgttctgaacaggacgagctggat
ttcctcatggaggccttgatcatcagcaaattcaaccaccagaacattgtgcgctgcatc
ggagtcagtctacaagccctaccccgcttcatcctgctggagctcatggcaggaggagac
ctcaagtctttcctccgggagacccggcctcgtccgaatcagccctcctccctggccatg
ctggacctgctgcatgtagctcgggacattgcctgtggctgtcagtacctagaggaaaac
cacttcatccaccgggacattgctgccaggaactgcctcttgacctgtccgggcacggga
agggtggcaaagattggagactttggcatggcacgagacatctacagagcaagctactac
agaaagggtgggtgtgccatgctgccagttaagtggatgcccccagaggccttcatggaa
ggaatatttacttccaaaacagacacctggtccttcggagtgctgctgtgggaaatcttc
tccctcggatacatgccgtaccccagcaaaagcaaccaggaggtcctggagtttgtcacc
agtggaggccggatggacccgcccaagaactgccccgggcctgtataccggataatgact
caatgctggcagcatcaacctgaagacaggcccaactttgccatcatcttggagaggatt
gaatactgcacccaggaccctgatgtgatcaacaccgccctgcccattgaatacgggccc
ctggtggaagaggaagaaaaggtgcccatgcggcccaaggaccccgagggcgtccctcca
ctgctggtgtctccagcccaggccacacgggaggaggtgcccgccccagccgcgccacct
gctctgccggccacttcctcaggcagagtcgccaagaaacccgcagcggccgaggtcccc
gcccgaggccctagagggtcagccatggaggggggacacgtgaacatggccttcgcccag
tctaccgtgccgtcagagctgcccaagggccaggcgtccagaaacaagccgaccagcctg
tggaacccgacctacggctcatggtttaccgagaaacccgccagaaagaacaatgccctg
gccaagaaggagccgcaggaccgggggcacccggggcaggagggaagctgtactgtcccg
ccgggcggtggtggcagcggcggtgtagcccccggccgcctcccggggggctccctgctc
ctggagccggcggcgctgactgccagcatgaaggaggtgccgctgttcaggctgcgccac
ttcccgtgcgggaatgtcaactacggctaccagcagcagggcttgccgctcgaggccgcc
gctggcccgggggccggccgctacgaggacccgatgctgaaagccaagggtagcggcaag
cagcctgggccctga

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