KEGG   Ornithorhynchus anatinus (platypus): 100079541
Entry
100079541         CDS       T01045                                 
Symbol
MTHFD1
Name
(RefSeq) C-1-tetrahydrofolate synthase, cytoplasmic isoform X1
  KO
K00288  methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase [EC:1.5.1.5 3.5.4.9 6.3.4.3]
Organism
oaa  Ornithorhynchus anatinus (platypus)
Pathway
oaa00670  One carbon pool by folate
oaa01100  Metabolic pathways
oaa01240  Biosynthesis of cofactors
oaa04981  Folate transport and metabolism
Module
oaa_M00141  C1-unit interconversion, eukaryotes
Brite
KEGG Orthology (KO) [BR:oaa00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    100079541 (MTHFD1)
 09150 Organismal Systems
  09154 Digestive system
   04981 Folate transport and metabolism
    100079541 (MTHFD1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:oaa04147]
    100079541 (MTHFD1)
Enzymes [BR:oaa01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.5  methylenetetrahydrofolate dehydrogenase (NADP+)
     100079541 (MTHFD1)
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.4  In cyclic amidines
    3.5.4.9  methenyltetrahydrofolate cyclohydrolase
     100079541 (MTHFD1)
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.4  Other carbon-nitrogen ligases
    6.3.4.3  formate---tetrahydrofolate ligase
     100079541 (MTHFD1)
Exosome [BR:oaa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   100079541 (MTHFD1)
SSDB
Motif
Pfam: FTHFS THF_DHG_CYH_C THF_DHG_CYH
Other DBs
NCBI-GeneID: 100079541
NCBI-ProteinID: XP_028918599
Ensembl: ENSOANG00000051013
LinkDB
Position
1:31387951..31478073
AA seq 980 aa
MIAVFPKRFLRAGHCAKRWAASEEMGPAPVPGPPGARRHHPPFPEEVAEAHGSAGALPRQ
VREKLKRQVAQMREQVPSFRPGLAILQVGNREDSNLYINMKLKAAEEIGIKATHIKLPNT
VTETEVLRCVTSLNEDSSIHGFIVQLPLDSEKMINIEAVTNAVAPEKDVDGLTSINAGKL
ARGDLGDCFIPCTPKGCLELIRETGVQIAGRHAVVIGRSKIVGAPMHDLLLWNNATVTTC
HSKTAKLAEEISRADILVVAAGKPEMVKGEWIKPGAVVIDCGINYVPDNSKPNGKRVVGD
VAYDEAKERASYITPVPGGVGPMTVAMLMQSTVESARRFLEKFKPGKWNIQYNQLRILNP
VPSDIEISRSCIPKTIGHLAREIGLLSEEVELYGQTKAKILLSTIERLKDQPDGKYVVVT
GITPTPLGEGKSTTTIGLVQALGAHLQQNVFACVRQPSQGPTFGIKGGAAGGGYSQVIPM
EEFNLHLTGDVHAITAANNLVAAAIDARMFHEMTQTDKALFNRLVPSVGGVRKFSEIQIR
RLQRLGIEKNSPETLTEEEINRFVRLDIDPETITWQRVLDTNDRFLRKITIGQSPTEKGY
TRMTQFDISVASEIMAVLALTNNLEDMRARLGKMVVASSKKGDPISTEDLGVSGALTVLM
KDAIKPNLMQTLEGTPVFVHAGPFANIAHGNSSILADKIALKLVGPEGFVVTEAGFGADI
GMEKFFNIKCRYSGLRPHVVVLVATVRALKMHGGGPTVTAGVPLPNEYTEENLDLLEKGF
KNLGKQIQNAWQFGVPVVVAVNAFKTDTEAELELIRRLSKEAGAYDAVKCTHWAEGGKGA
VALAQAVERASRSPSDFRLLYDVELPVVEKIRIIAQKIYGASDIELLPEAQHKVDVYTKQ
GFGNLPICMAKTHLSLSHDPEKKGVPTDFILPIRDIRASVGAGFLYPLVGTMSTMPGLPT
RPCFYDIDLDPVSEQVNGLF
NT seq 2943 nt   +upstreamnt  +downstreamnt
atgatcgccgtatttcctaaacgcttcctgcgtgctgggcactgcgctaagcgctgggct
gcatccgaagaaatggggccggccccagtccctggccctcctggggctcgccgtcaccat
cccccttttcccgaggaggtcgccgaggcacacggaagtgcgggggctctcccgaggcaa
gtaagggagaaactgaagagacaagttgctcagatgagagagcaagtgccgagtttcaga
ccaggcctggcgatattacaggttggaaaccgagaggattcaaatctctatataaatatg
aagctgaaagcagctgaagagattggaatcaaagccacacatatcaagttgccaaacact
gtaacagaaaccgaggtattgaggtgtgtcacatctctcaacgaagattcttccattcat
ggattcatagtgcagttacctttggattctgagaagatgatcaatattgaggcagtgacc
aatgccgttgcaccagaaaaggacgtagacggattaaccagcattaacgctgggaagctt
gctcgaggtgacctgggagattgctttatcccctgtacgcctaaggggtgtttggaactc
atcagagagactggggtgcagatcgccgggaggcatgctgtggtgattggccgcagtaag
atcgtcggtgcccccatgcacgatcttctgctgtggaacaatgccaccgtgactacctgt
cactcaaagacagcgaagttagccgaagagatcagcagagctgatattctggtagtggcg
gccggaaaacctgaaatggtgaaaggagagtggataaaacccggcgccgtagttatagac
tgtggaatcaactacgtacccgacaattcaaagcccaatgggaaaagagttgttggagat
gtggcttacgacgaagcaaaagagcgggcttcgtacatcactccggttccaggaggagtt
ggacctatgaccgttgcaatgttaatgcagagcacagtagagagtgcaagacgtttcctg
gaaaaattcaagcctggaaagtggaacatccagtataatcagctccggattctaaatcct
gtcccgagcgacattgaaatatcgcgatcttgtatcccgaagactattggtcacctggct
cgagagattggtttgctttccgaagaggtggaactgtacggccagaccaaagccaagatt
ctgctctctaccatagaacgtctgaaggatcaacctgatggaaaatacgtcgtcgttacc
ggaatcactcctacacccctgggagaagggaaaagcacgaccacgatcggattagtccaa
gctctgggagctcaccttcagcagaacgtctttgcttgtgtacgacagccatctcaaggg
ccaacctttgggatcaaaggtggagctgcaggcgggggatattctcaagttattccaatg
gaagaattcaatcttcatctcactggtgatgttcacgccattacggctgctaataaccta
gttgccgctgctattgatgcccgcatgttccatgagatgacccagacggataaggcactt
tttaatcgcttggttccttcagttggtggcgttaggaagttttctgagattcagatccga
agattacagagacttggcattgagaaaaacagccctgaaacgttgaccgaggaagagata
aacagattcgtgagattggatatcgatccagaaaccataacttggcaaagagtattagat
acaaatgacagattcctgaggaagatcacaattggacaatctccaactgagaaaggctac
acaagaatgacccagtttgacatttctgtggctagtgaaatcatggcagtcttggctctc
acgaataatctggaagacatgagagcaagactgggcaagatggtggtggcttctagcaaa
aaaggagatccgatcagtacagaagatttgggggtgagtggagctttgacagtactcatg
aaggatgctataaagcccaatcttatgcagacactagagggaactccagtgtttgttcat
gctggaccatttgccaatattgcacatggcaactcctcgattctagcagataaaattgcg
ctgaagcttgtgggccctgaaggtttcgtagtgacagaagcaggatttggagcagacatt
ggaatggaaaagttttttaacattaagtgccgatattctggtctccgtcctcatgtggtg
gtgctcgttgcaaccgtcagagctcttaagatgcatgggggaggccccacagttactgct
ggagtgcctctaccaaatgaatacacagaggagaacttggacctactggagaagggcttt
aaaaacttgggcaaacaaattcagaatgcctggcagtttggagttccagtagtcgttgct
gtcaatgctttcaaaactgacacagaagccgaactggagctgatccgccgcctgtcgaaa
gaagcgggagcgtatgacgccgtgaaatgcactcactgggccgagggagggaaaggagcc
gttgctttggcccaggccgtcgagagggcctcacggtcacccagtgatttccgactcctt
tacgatgtggagcttccagttgtagagaagatcagaatcattgcacagaagatctatgga
gcaagtgacattgaattgcttccagaagctcagcacaaagttgacgtctacacgaaacag
ggatttggaaacctgccaatatgcatggccaaaacacacctgtccttgtctcatgaccca
gaaaagaaaggtgtgcctacggactttattctgccaatccgagatatccgggccagtgtc
ggtgctggtttcctgtaccctttagttggcacaatgagcaccatgccaggcctgcctact
cgaccatgtttttatgacatcgatctggatcctgtatcagaacaagtcaatgggttattc
tga

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