KEGG   Mirounga leonina (Southern elephant seal): 118002597
Entry
118002597         CDS       T07472                                 
Symbol
MTHFD1
Name
(RefSeq) C-1-tetrahydrofolate synthase, cytoplasmic isoform X1
  KO
K00288  methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase [EC:1.5.1.5 3.5.4.9 6.3.4.3]
Organism
mlx  Mirounga leonina (Southern elephant seal)
Pathway
mlx00670  One carbon pool by folate
mlx01100  Metabolic pathways
mlx01240  Biosynthesis of cofactors
mlx04981  Folate transport and metabolism
Module
mlx_M00141  C1-unit interconversion, eukaryotes
Brite
KEGG Orthology (KO) [BR:mlx00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    118002597 (MTHFD1)
 09150 Organismal Systems
  09154 Digestive system
   04981 Folate transport and metabolism
    118002597 (MTHFD1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:mlx04147]
    118002597 (MTHFD1)
Enzymes [BR:mlx01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.5  methylenetetrahydrofolate dehydrogenase (NADP+)
     118002597 (MTHFD1)
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.4  In cyclic amidines
    3.5.4.9  methenyltetrahydrofolate cyclohydrolase
     118002597 (MTHFD1)
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.4  Other carbon-nitrogen ligases
    6.3.4.3  formate---tetrahydrofolate ligase
     118002597 (MTHFD1)
Exosome [BR:mlx04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   118002597 (MTHFD1)
SSDB
Motif
Pfam: FTHFS THF_DHG_CYH_C THF_DHG_CYH Herpes_PAP OCD_Mu_crystall
Other DBs
NCBI-GeneID: 118002597
NCBI-ProteinID: XP_034849062
LinkDB
Position
Unknown
AA seq 935 aa
MAPAEILNGKVISAQIRETLKNQVTQMKEQFPGFTPGLAILQVGDRDDSNLYINVKLKAA
EEIGIKATHIKLPRTATESEVLKYVTSLNEDLTVHGFIVQLPLDAENPINTDAVVNAIIP
GKDVDGLTSINAGKLARGDLNDCFIPCTPKGCLALIKETGVQIAGRHAVVVGRSKIVGAP
MHDLLLWNHATVTTCHSKTANLGEEVNKGDILVVATGQPEMVKGEWIKPGAIVIDCGINY
IPDDTKPNGKKVVGDVAYDEAKERAGFITPVPGGVGPMTVAMLMQSTVESAKRFLEKFKP
GKWMIQYNNLNLQVPVPSDIDISRSCKPKPIGSLAQEIGLLSEEVELYGETKAKVLLSAL
ERLKHQPNGKYVVVTGITPTPLGEGKSTTTIGLVQALGAHLSQNVFACVRQPSQGPTFGI
KGGAAGGGYSQVIPMEEFNLHLTGDIHAITAANNLVAAAIDARMFHELTQTDKALFNRLV
PSVNGVRKFSDIQIRRLQRLGIEKTDPTTLTDDEINRFARLDIDPETITWQRVLDTNDRF
LRKITIGQAPTEKGHTRTAQFDISVASEIMAVLALTSSLEDMRERLSRMVVASSKKGEPI
STEDLGVSGALTVLMKDAIKPNLMQTLEGTPVFVHAGPFANIAHGNSSIIADRIALKLVG
PEGFVVTEAGFGADIGMEKFFNIKCRYSGLRPHVVVLVATVRALKMHGGGPTVTAGLPLP
KAYIEENLELVEKGFSNLRKQIENARMFGVPVVVAVNAFKTDSEAELDLISRLAKDHGAF
DAVKCTHWAEGGKGALALAQAVQRAAQAPSSFQLLYDLKLPIEDKIRIIAQKIYGADDIE
LLPEAQHKVEVYTKQGFGHLPICMAKTHLSLSHNPEQKGVPTGFVLPIRDIRASVGAGFL
YPLVGTMSTMPGLPTRPCFYDIDLDPETEQVNGLF
NT seq 2808 nt   +upstreamnt  +downstreamnt
atggcaccggcggaaatcctgaacgggaaggtgatctccgcgcaaatcagggagacactg
aagaaccaagtcactcagatgaaggagcaatttcctggttttacaccaggcctggcaatt
ttacaggttggcgacagagatgattctaatctttatataaatgtgaagctgaaggctgct
gaagagattgggatcaaagccacgcacattaagttaccaagaactgccacagaatctgag
gtgttaaagtacgttacatcattgaatgaagacctcaccgtacatggtttcatagtacag
ctgcctttagatgcagagaaccccattaacactgacgcagtggtcaatgcgatcataccc
ggaaaggatgtggatgggttaactagcatcaatgctggaaaacttgcaagaggtgaccta
aatgactgtttcatcccttgtacgcctaaaggatgcttggcactcatcaaagagacaggg
gtgcagatcgctggaaggcacgcggtcgtggtcgggcgcagtaagatagtcggtgccccc
atgcatgacttgcttctgtggaaccatgccacagtgaccacctgccactccaagactgcc
aatctaggcgaggaggtaaataaaggtgacatcctggtggttgcgactggtcagccggaa
atggtgaaaggggagtggatcaaacccggggcaatagtcatcgactgcgggatcaattat
atcccagatgatacaaaaccaaatgggaaaaaagtggtgggtgatgtggcctatgatgag
gccaaagagagggcaggcttcatcactcctgttcctggtggtgtggggcccatgacggtg
gcaatgctaatgcagagcacagtagagagtgcaaagcgtttcttggagaaatttaagcca
ggaaagtggatgattcagtataacaaccttaacctccaggttcctgttccaagtgacatt
gatatatcacgatcttgcaagccaaagcccattggcagcctggctcaggagattggtctg
ctgtctgaggaggtagaattgtatggtgagacaaaagccaaggttctgctgtctgcactg
gaacgcctgaagcaccaacctaacgggaaatacgtggtggtgaccgggatcactccaacg
cccctgggagaagggaagagcacgaccaccattgggctggtgcaggcccttggtgcccat
ctttctcagaacgtctttgcgtgtgtgcgacagccttctcagggccccacctttggaata
aaaggtggcgctgcaggaggtggctactcacaggtcattcccatggaagagtttaatctc
cacctcaccggcgacatccatgccatcactgcagcaaataaccttgtcgccgcggccatt
gatgcccggatgttccatgaactgacacagacagacaaggctctcttcaatcgtttggta
ccatcagtaaatggagtgagaaagttctccgatatccaaatccgaaggttacagagacta
ggcattgaaaaaaccgaccctaccacactgactgacgacgagataaacagatttgcaaga
ttggacattgatccagaaaccataacttggcaaagagtattggataccaatgatagattc
ctgaggaagatcaccatcggacaggctccaacggagaaagggcacacacggacggcccag
tttgatatctctgtggccagtgaaatcatggctgtgctggctctcaccagttcgctagaa
gacatgagagagagactgagcagaatggtggtggcatccagcaagaaaggggagcccatc
agtaccgaagatctgggggtgagtggtgcattgacagtgcttatgaaggatgcaatcaag
cccaatctcatgcagacattagagggcactccagtatttgttcatgctggaccatttgcc
aacattgcacatgggaattcctctatcattgcagaccggattgccctcaagcttgttggc
cctgaggggtttgtggtgactgaagcaggatttggagcggacattggaatggaaaagttt
tttaacatcaaatgccggtattctggtctccgccctcacgtcgtggtgcttgtggccaca
gtcagggctcttaagatgcacggaggcggccccacggttactgctggactgcctctcccc
aaggcttacatagaggagaacctggagctggttgaaaaaggcttcagtaacttaaggaaa
caaattgaaaatgccagaatgtttggagtcccagtggtagtggccgtgaacgcattcaag
acagattcggaggccgagctggacctcatcagccgccttgccaaagatcatggggctttt
gatgcagtgaaatgcacacactgggcagaagggggcaagggcgccttagccctggctcag
gccgtccagagagcagctcaagcacccagcagcttccagctcctttatgacctcaagctc
ccgattgaggataaaatcaggatcattgcgcagaagatctatggggctgatgacattgaa
ctgcttcctgaagctcaacacaaagttgaagtctacacaaaacagggctttgggcacctg
cccatctgcatggccaagacacacttgtccttgtctcataacccagagcagaagggtgtg
cccacaggctttgtcctgcccatccgtgacatccgtgccagtgttggggccggttttctg
taccccttggtaggcacgatgagcacgatgcctggactccccacacggccctgtttctat
gatattgatttggaccctgaaactgaacaggttaatgggttgttctaa

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