KEGG   Mandrillus leucophaeus (drill): 105538460
Entry
105538460         CDS       T08763                                 
Symbol
MTHFD1
Name
(RefSeq) C-1-tetrahydrofolate synthase, cytoplasmic
  KO
K00288  methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase [EC:1.5.1.5 3.5.4.9 6.3.4.3]
Organism
mleu  Mandrillus leucophaeus (drill)
Pathway
mleu00670  One carbon pool by folate
mleu01100  Metabolic pathways
mleu01240  Biosynthesis of cofactors
mleu04981  Folate transport and metabolism
Module
mleu_M00141  C1-unit interconversion, eukaryotes
Brite
KEGG Orthology (KO) [BR:mleu00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    105538460 (MTHFD1)
 09150 Organismal Systems
  09154 Digestive system
   04981 Folate transport and metabolism
    105538460 (MTHFD1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:mleu04147]
    105538460 (MTHFD1)
Enzymes [BR:mleu01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.5  methylenetetrahydrofolate dehydrogenase (NADP+)
     105538460 (MTHFD1)
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.4  In cyclic amidines
    3.5.4.9  methenyltetrahydrofolate cyclohydrolase
     105538460 (MTHFD1)
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.4  Other carbon-nitrogen ligases
    6.3.4.3  formate---tetrahydrofolate ligase
     105538460 (MTHFD1)
Exosome [BR:mleu04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   105538460 (MTHFD1)
SSDB
Motif
Pfam: FTHFS THF_DHG_CYH_C THF_DHG_CYH OCD_Mu_crystall
Other DBs
NCBI-GeneID: 105538460
NCBI-ProteinID: XP_011833718
LinkDB
Position
Unknown
AA seq 1050 aa
MQRRTVDWLFLSANHIRQPFITDFLHLPLPLPSLRPRPFCSQLVKGHRAFRAAHALPRLP
RSGQGRRRSSVIPWPVPKHVGWAVLLGCRGTGTSILVVSIVGSGLIKAMAPAEILNGKEI
SAQIRARLKNQVTQLKEEVPGFIPGLAILQIGNRDDSNLYIKVKLKAAEEIGIKATHIKL
PRTTTESEVIKYVTSLNEDSTIHGFLVQLPFDSENSINTEEVINAIAPEKDVDGLTNISA
GKLARGDLNDCFIPCTPKGCLELIKETGVPIAGRHAVVVGRSKIVGAPMHDLLLWNNATV
TTCHSKTANLNEEVNKGDILVVATGQPEMVKGEWIKPGAIVIDCGINYVPDDKTNGRKVV
GDVAYDEAKERASFITPVPGGVGPMTVAMLMQVLVNKSFCKSSEKLIEITPTPLGEGKST
TTIGLVQALGAHLYQNVFACVRQPSQGPTFGIKGGAAGGGYSQVIPMEEFNLHLTGDIHA
ITAANNLVAAAIDARIFHELTQTDKALFNRLVPSVNGVRKFSDIQIRRLKSTVESAKRFL
EKFKPGKWMIEYNNLNLKTPVPSDIDISRSCKLKPIGKLAREIGLLSEEVELYGETKAKV
LLSALERLRHRPDGKYVVVTGCLSAIVLDTNDRFLRKITIGQAPTEKGHTRTAQFDISVA
SEIMAVLALTTSLEDMRERLGKMVVASSKKGEPVSAEDLGVSGALTVLMKDAIKPNLMQT
LEGTPVFVHAGPFANIAHGNSSILADRIALKLVGPEGFVVTEAGFGADIGMEKFFNIKCR
YSGLRPHVVVLVATVRALKMHGGGPTVTAGLPLPKAYIEENLELVEKGFSNLKKQIENAR
MFGIPVVVAVNAFKTDTEAELDLISRLSREHGAFDAVKCTHWAEGGKGALALAQAVQRAA
QAPSSFQLLYDLKLPVEDKIRIIAQKIYGADDIELLPEAQHKAEVYTKQGFGNLPICMAK
THLSLSHNPEQKGVPTGFVLPIRDIRASVGAGFLYPLVGTILIHLQEATLKVWPVSIQAH
WELGSIRKPREVSPCPETNSRSFPGSHFQP
NT seq 3153 nt   +upstreamnt  +downstreamnt
atgcaaaggcgcactgtggactggctctttctttccgccaatcatatccgccagccattc
atcaccgattttcttcatcttcccctccctcttccgtccctcaggccccgacccttttgc
tctcagctggttaagggacaccgggccttccgggctgcgcatgcgctgccgcgtctgcca
agaagcgggcaggggcgcaggcgcagtagtgtgatcccctggccagtccctaagcacgtg
ggttgggctgtcctgcttggctgcagagggactggaacctcgatattggtggtgtccatc
gtgggcagcggactaataaaggctatggcgccagcagaaatcctgaacgggaaggagatc
tccgcgcaaataagggcgagactgaaaaatcaagtcactcagttgaaggaggaagtacct
ggtttcataccaggcctggcaatattacagattggcaacagagatgattccaatctttat
ataaaagtgaagctgaaggctgctgaagagattgggatcaaagccactcacattaagtta
ccaagaacaaccacagaatctgaggtgatcaagtacgttacatctttgaatgaagactct
actatacacgggttcttagtgcagctaccttttgattcagagaattccattaacactgaa
gaagtgatcaatgctattgcacccgagaaggatgtggatggattgaccaacatcagtgct
gggaaacttgctagaggtgacctcaatgactgtttcattccttgtacgcctaagggatgc
ttggaactcatcaaagagacaggggtgccgattgccggaaggcatgctgtggtggtcggg
cgcagtaaaattgtcggggccccgatgcatgacttgcttctgtggaacaatgccacagtg
accacctgccactccaagactgccaatctgaatgaggaggtaaataaaggtgacatcctg
gtggttgcaactggtcagcctgaaatggttaaaggggagtggatcaaacctggggcaata
gtcatcgactgtggaatcaattatgtcccagatgataaaacaaatgggagaaaagttgtg
ggtgatgtggcatacgacgaggccaaagagagggcaagcttcatcactcctgttcctggc
ggcgtagggcccatgacggttgcaatgctcatgcaggtacttgtgaataaaagtttctgt
aagagttctgaaaagctgattgaaataactccaacacccctgggagaagggaaaagcaca
actacaattgggctagtgcaagcccttggtgcccatctctaccagaacgtctttgcatgt
gtgcgacagccatctcagggtcccacctttggaataaaaggtggcgctgcaggaggaggt
tactcccaggtcattcctatggaagagtttaatctccatctcacaggtgacatccatgcc
atcactgcagctaataacctcgttgctgcggccattgatgctcggatatttcatgaactg
acccagacagacaaggctctctttaatcgtttggtgccatcagtaaatggagtgagaaag
ttctctgatatccaaatccgaaggttaaagagcacagtagagagtgccaagcgtttcctg
gagaaatttaagccaggaaagtggatgattgagtataacaaccttaacctcaagacacct
gttccaagtgacattgatatatcacgatcttgtaaactgaagcccattggtaagctggct
cgagaaattggtctgctgtctgaagaggtagaattatatggtgaaacaaaggccaaagtt
ctgctgtcagcactagagcgcctgaggcaccggcctgatgggaaatacgtggtggtgact
ggttgcctgtctgctatagtgttggataccaatgatagattcctgaggaagatcacgatt
ggacaggctccaacagagaagggtcacacacggacggcccagtttgatatctctgtggcc
agtgaaattatggctgtgctggctctcaccacttctctagaagacatgagagagagactg
ggcaaaatggtggtggcatccagtaagaaaggggagcccgtcagtgccgaagatctgggg
gtgagtggtgcattgacagtgcttatgaaggacgcaatcaagcccaatctcatgcagaca
ttggagggcactccagtgtttgtccatgctggcccgtttgccaacatcgcacatggcaat
tcctccatccttgcagaccggatcgcactgaagcttgttggaccagaagggtttgtagtg
acggaagcgggatttggagcagacattggaatggaaaagttttttaacatcaaatgccgg
tattccggcctccgccctcacgtggtggtgcttgttgccactgtcagagctctcaagatg
cacgggggcggccccacggtcactgctggactgcctcttcccaaggcttacatagaggag
aacctggagctggttgaaaaaggcttcagtaacttgaagaaacaaatcgaaaatgccaga
atgtttggaattccagtagtagtggccgtgaatgcattcaagacagacacagaggctgag
ctggacctcatcagccgcctttccagagaacatggggcttttgatgccgtgaagtgcact
cactgggcagaagggggcaagggtgccttagccctggctcaggccgtccagagagcagca
caagcacccagcagcttccagctcctttatgacctcaagctcccagtcgaggataaaatc
aggatcattgcacagaagatctatggagcagatgacattgaattactccccgaagctcaa
cacaaagctgaagtctacacaaagcagggctttgggaatctccccatctgcatggctaaa
acacacttgtctttgtctcacaacccagagcaaaaaggtgtccctacaggcttcgttctg
cccattcgcgacatccgcgccagcgtcggggctggttttctgtaccccttagtaggaaca
atcctcatccatcttcaagaagctactttgaaagtctggccagtgtctattcaggcccac
tgggagttaggaagcataaggaagccaagagaagtcagcccctgcccagaaactaatagt
aggagtttccccggaagtcattttcagccttaa

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