KEGG   Manis javanica (Malayan pangolin): 108396567
Entry
108396567         CDS       T06054                                 
Symbol
MTHFD1
Name
(RefSeq) C-1-tetrahydrofolate synthase, cytoplasmic
  KO
K00288  methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase [EC:1.5.1.5 3.5.4.9 6.3.4.3]
Organism
mjv  Manis javanica (Malayan pangolin)
Pathway
mjv00670  One carbon pool by folate
mjv01100  Metabolic pathways
mjv01240  Biosynthesis of cofactors
mjv04981  Folate transport and metabolism
Module
mjv_M00141  C1-unit interconversion, eukaryotes
Brite
KEGG Orthology (KO) [BR:mjv00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    108396567 (MTHFD1)
 09150 Organismal Systems
  09154 Digestive system
   04981 Folate transport and metabolism
    108396567 (MTHFD1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:mjv04147]
    108396567 (MTHFD1)
Enzymes [BR:mjv01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.5  methylenetetrahydrofolate dehydrogenase (NADP+)
     108396567 (MTHFD1)
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.4  In cyclic amidines
    3.5.4.9  methenyltetrahydrofolate cyclohydrolase
     108396567 (MTHFD1)
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.4  Other carbon-nitrogen ligases
    6.3.4.3  formate---tetrahydrofolate ligase
     108396567 (MTHFD1)
Exosome [BR:mjv04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   108396567 (MTHFD1)
SSDB
Motif
Pfam: FTHFS THF_DHG_CYH_C THF_DHG_CYH AcetDehyd-dimer OCD_Mu_crystall Wza_C
Other DBs
NCBI-GeneID: 108396567
NCBI-ProteinID: XP_036862295
LinkDB
Position
Unknown
AA seq 935 aa
MAPAEVLNGKVVSEQIKERLKNQVAQMKEQVPGFTPGLAVLQVGNRDESNVYINLKLKAA
EEIGIKATHIKLPRTATESEVLKYVTSLNEDNTVHGFIVQLPLDSENPVNTEAVVNAIVP
EKDVDGLTSISAGKLAKGDLNDCFIPCTSKGCLELIKKTGVQIAGKHAVVVGRSQIVGAP
MHALLLWNHATVTICHSKTANLSEEVNKGDILVVAAGQPEIVKGEWIKPGAVVIDCGINY
VPDNTKLNGKKVVGDVAYDEAKERAGFITPVPGGVGPMTVVMLMQSTVESAKRFLEKCKP
GKWMIDYNELNLKAPVPSDIDISRSCKPKPIGSLAREIGLLSEEVELYGETKAKVLLSTL
ERLNHQPDGKYVVVTGITPTPLGEGKSTTTIGLVQALGAHLHQNVFACVRQPSQGPTFGI
KGGAAGGGYSQVIPMEEFNLHLTGDIHAITAANNLVAAAIDARMFHELTQTDKALFNRLV
PSINGVRKFSDIQLRRLRRLGIEKTDPTTLTDEEINRFARLDIDPETITWQRVLDTNDRF
LRKITIGQAPTEKGYTRTTQFDISVASEIMAVLALTTSLEDMRERLSKMVVASSKKGEPI
SAEDLGVSGALTVLMKDAIKPNLMQTLEGTPVFVHAGPFANIAHGNSSIIADRIALKLVG
PEGFVVTEAGFGADIGMEKFFNIKCRYSGLCPHVVVLVATVRALKMHGGGPTVTAGLPLP
KAYIEENLELVEKGFSNLKKQIENARLFGVPVVVAMNAFKTDTEAELDLVNRLAKEHGAF
EAVKCTHWAEGGKGALALAQAVQRAAQAPSSFKLLYDLKLPVEDKIRIIAQKIYGADDIE
LLPEAQHKAEVYTKQGFGNLPICMAKTHLSLSHNPEQKGVPTGFVLPIRDIRASVGAGFL
YPLVGSMSTMPGLPTRPCFYDIDLDPETEQVNGLF
NT seq 2808 nt   +upstreamnt  +downstreamnt
atggcaccggcggaagtcctgaacgggaaagtggtctcagaacaaataaaggagagactg
aagaaccaagtcgctcagatgaaggagcaagtaccgggtttcacaccaggcctggcggtt
ttacaggttggcaacagagacgagtccaatgtttatataaatttgaagctgaaggctgct
gaagagattggaattaaagccactcacattaagttaccaagaacagccacagaatctgag
gtgttaaagtatgttacatctttgaatgaagacaacactgtacatgggttcatagtgcag
ctacccttagattcagagaatccagttaacactgaagctgtggtcaatgctattgtacct
gagaaggatgtggatggattgactagcatcagtgctggaaaacttgctaaaggtgaccta
aatgactgtttcatcccatgtacatctaaaggatgcttggaactcatcaaaaagacaggg
gtgcagattgctgggaagcatgctgtggtggttgggcgcagtcaaatagtcggtgcccca
atgcatgccttgcttctgtggaaccatgccacagtgaccatctgtcactccaagactgcc
aatctaagtgaggaggtaaataaaggtgacattctggtggtggcagctggtcagcctgaa
atagtgaaaggggagtggatcaaacccggggcagtggtcatcgactgtggaatcaattat
gtcccagacaatacaaaactaaatgggaagaaagtcgtgggtgatgtggcatacgacgag
gccaaagagagggcgggcttcatcactccagttcccggcggtgtcgggcccatgacggtg
gtgatgctgatgcagagcacagtggagagtgcaaagcgtttcctggagaaatgtaagcca
ggaaagtggatgattgactataatgagcttaatctcaaggcacctgtcccaagtgacatt
gatatatcacggtcttgcaagccaaagcccattggtagcctggctcgagaaattggtcta
ctctctgaagaggtagaactgtatggggaaacaaaagccaaagtcctgctgtcgacactg
gagcgcctgaatcaccagcctgatggaaaatatgtggtggtaactggaataactccaacg
cccctgggagaagggaaaagcacaaccacaatcgggctagtgcaagccctgggtgcccac
ctgcatcagaacgtctttgcgtgtgtgcgacagccttctcagggccctacctttggaata
aaaggtggcgctgcaggaggtggctactcacaggtcattcctatggaagagtttaatctc
cacctcactggtgacatccatgccatcactgctgctaataaccttgttgctgcagccatt
gatgcccggatgttccatgaactgacccagacagacaaggcactctttaatcgtttggta
ccatcaataaatggagtgagaaagttctctgatatccaactccgaaggttacggagacta
ggcattgaaaagactgaccctaccactctgacagatgaagagataaacagatttgcaaga
ttggatattgatccagaaaccataacttggcaaagagtgttggataccaatgataggttc
ctgaggaagatcacaattggacaggctcccacagagaaagggtacacacggacgactcag
tttgatatctctgtggccagtgagatcatggctgtcctggctctcaccacttctctggaa
gacatgagagagagactgagcaaaatggtggtggcatccagcaagaaaggggagcccatc
agtgctgaagatctgggagtgagtggcgcattgacagtgctcatgaaggatgcaatcaag
cctaatctcatgcagacattagagggcaccccagtatttgttcatgctggaccatttgcc
aacattgcacatgggaattcctccatcattgcagaccggattgctctcaagcttgttggc
cctgaagggtttgtagtgactgaagcaggattcggagcagacattggaatggaaaagttt
tttaacatcaaatgccggtattcgggtctctgtcctcatgtggtggtgcttgtcgccaca
gtcagggctcttaaaatgcatggaggcggccccacggttactgccggactacctcttccg
aaggcttacatagaggagaacctagagctggttgaaaaaggcttcagcaacttgaagaaa
cagattgaaaatgccagactgtttggagtgccagtagtagtggccatgaatgcattcaag
acagacacggaggcagagctggacctcgtcaaccgccttgccaaagaacacggggctttt
gaggctgtgaagtgcactcactgggcagaagggggcaagggcgccttagccctggctcag
gccgtccagagagcagcacaggcacccagcagcttcaagctcctttatgacctcaagctc
ccagttgaagataaaatcagaatcattgcccagaagatctatggggcagatgacattgaa
ttgctcccggaggcccagcacaaagcagaagtctacacaaagcagggcttcgggaatctg
cccatctgcatggccaaaacacacttgtccttgtctcataatccagaacagaaaggcgtg
cccacaggcttcgtcctacccatccgtgatatccgcgccagcgtcggggctggttttcta
taccccttggtaggatcgatgagcacaatgcctggactccctacccggccttgtttctat
gacattgatttggaccctgaaactgaacaagtgaatgggctgttctaa

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