KEGG   Kluyveromyces marxianus: KLMA_70359
Entry
KLMA_70359        CDS       T05269                                 
Symbol
MIS1
Name
(RefSeq) C-1-tetrahydrofolate synthase
  KO
K00288  methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase [EC:1.5.1.5 3.5.4.9 6.3.4.3]
Organism
kmx  Kluyveromyces marxianus
Pathway
kmx00670  One carbon pool by folate
kmx01100  Metabolic pathways
kmx01240  Biosynthesis of cofactors
kmx04981  Folate transport and metabolism
Module
kmx_M00141  C1-unit interconversion, eukaryotes
Brite
KEGG Orthology (KO) [BR:kmx00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    KLMA_70359 (MIS1)
 09150 Organismal Systems
  09154 Digestive system
   04981 Folate transport and metabolism
    KLMA_70359 (MIS1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:kmx04147]
    KLMA_70359 (MIS1)
Enzymes [BR:kmx01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.5  methylenetetrahydrofolate dehydrogenase (NADP+)
     KLMA_70359 (MIS1)
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.4  In cyclic amidines
    3.5.4.9  methenyltetrahydrofolate cyclohydrolase
     KLMA_70359 (MIS1)
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.4  Other carbon-nitrogen ligases
    6.3.4.3  formate---tetrahydrofolate ligase
     KLMA_70359 (MIS1)
Exosome [BR:kmx04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   KLMA_70359 (MIS1)
SSDB
Motif
Pfam: FTHFS THF_DHG_CYH_C THF_DHG_CYH
Other DBs
NCBI-GeneID: 34718105
NCBI-ProteinID: XP_022677962
LinkDB
Position
7:complement(735644..738565)
AA seq 973 aa
MLRSPLRNAIKYSPVRLLKSSNRHHQQYVHIAKCQYHLLSGTKIAKSIREDAFQEITRIK
EKAPEFVPCLKIIQVGSRPDSSAYVRMKLKASEESGVKCIVEKLPEDIGELELLQKIQKI
NDDDSIHGLLIQLPLPRHLNETEITNAVSYTKDVDGFHRYNVGELSKRGGKPYFLPCTPN
GCIRLLKESGIDLKGKRAVVIGRSDIVGTPVASLLKDLNATVTICHRYTENIADVVKNAD
VVIAACGVPNMVKPDWLKQDAIVIDVGINYIPDATKKSGKRLVGDVDFEACKEKASYITP
VPGGVGPMTVAMLVQNVVLAAKRQLQNATKLPQIKPLPLKLETKVPSDIEISRKQAPKYI
KTVAEELGVHHSELELYGHYKAKLSPKIIKRLAENEDGKYILVAGITPTPLGEGKSTTTI
GLVQALSAHLQKPSIANVRQPSMGPTFGVKGGAAGGGYAQVIPMDEFNMHLTGDIHAIGA
ANNLLAAAIDTRMFHEATQKKHETFYKRLVPVKKGTRSFTPSMLKRLEKLGINKTNPDDL
TTEEIVKFARLNIDPDTITIKRVVDVNDRMLRQITIGQAPTEKGFTRQTGFDITVASELM
AILALSKDLKDLRERVGRIVIGSNYDKEPITVEDIGCGGAIAALLKDAVKPNLMQTLEGT
PVLVHAGPFANISIGASSVIADRVALKLVGKPKNADEGVESGYVVTEAGFDFTMGGERFF
NIKCRASGLTPNAVVLVATVRALKLHGGAPDVKPGQSLPEEYTQENVELVKNGTANMCKQ
IENIKQFGIPVVVAVNRFESDTEAEIDAIKEAAQKAGAFDVVSTNHWAEGGKGAINLAKS
VIEASKQPSDFKFLYDVNDTVEEKLSTIVTKMYGGAKIEISEEAQKKIDMYREQGFGNLP
ICIAKTQYSLSHDAKLKNVPTGFTFPIRDVRASIGAGYLYALAAEIQTIPGLSTHAGYMN
VEIDEDGEIEGLF
NT seq 2922 nt   +upstreamnt  +downstreamnt
atgctaaggtctcccttgagaaatgctattaaatatagcccagtgcgtctactgaaaagt
tccaataggcatcatcaacaatatgtgcacattgcgaagtgccagtaccatttgctttcc
ggtacgaagattgccaagtcgatcagggaggatgcgttccaggagatcacacggatcaaa
gagaaggcgcctgaatttgtgccatgtttgaagattatccaagtgggatctcgtccagat
tcttcggcgtacgttcgcatgaagttgaaggcatctgaggagtctggtgtgaagtgtatt
gtggagaagcttcccgaggatatcggggaactggagttgttacaaaagatccagaagatt
aacgacgatgactctattcatgggttgttgatccaacttccattgcctagacatttgaac
gagacggaaatcacgaatgctgtttcttacaccaaggatgtggatgggttccatcgctac
aacgttggggaattgtccaagagaggtggtaagccttatttcttgccatgcacgccaaac
gggtgtatcaggttgctaaaggaatctggtattgacttgaagggaaaacgtgcggtggtt
attgggagatcagacatcgttggtactccggttgcttctctattgaaggaccttaacgcg
acggtcacgatctgccacagatacactgagaatattgcagatgtggttaaaaacgcagac
gttgttattgcggcttgtggtgtgcccaacatggttaagccagattggttgaaacaggat
gccattgtcattgacgttggtatcaactacattccagatgctaccaagaaatccggtaaa
agattggttggtgatgtcgactttgaggcttgtaaggaaaaggcctcgtacattaccccg
gttccaggtggagtgggtcctatgaccgttgccatgcttgtccagaatgtagttttggct
gctaagagacaactgcaaaatgccaccaagttaccacaaatcaagccattacctttgaag
ttggagactaaagtcccatcagatatcgaaatttcaagaaaacaagctcccaagtacatc
aaaactgttgctgaagagctcggcgttcatcacagcgaattagagctttatggccactat
aaggcaaagttatcgccaaagattatcaagagattggcagaaaatgaggatgggaaatac
attcttgttgctggtattacacctaccccattgggtgaaggtaaatccaccactactatc
ggtttggttcaagcgctctcggcccatctacaaaaaccttccattgcaaatgtcagacag
ccttcgatgggtcctacattcggtgttaaaggtggtgcagcaggtggtggttatgcccaa
gtcattccaatggacgagttcaacatgcatctaaccggtgacattcatgccatcggtgct
gctaacaacttgttggcagctgctattgacactagaatgttccacgaagccactcaaaag
aaacacgaaaccttctacaagagattggttcctgttaagaagggtacaagaagcttcact
ccatctatgctaaagagattggagaagttgggtatcaataagacgaacccagatgacttg
accaccgaggaaattgtcaaattcgcccgtttgaacatcgatcctgacactatcactatc
aagagagttgttgacgtcaacgacagaatgctacgtcaaattaccattggccaagcccca
acagagaagggattcacaagacaaacaggtttcgatatcacagtcgcttccgaattgatg
gccattctagccttatccaaagacttgaaagacctcagagaacgtgtcggacgtattgtt
attggttcaaactacgacaaggaaccaattacagtagaggatattggatgtggtggtgcc
atcgcagctcttttaaaggatgcggttaaaccaaatttgatgcaaactctagagggaaca
ccagttctggtccacgctggtccctttgccaacatatccattggtgcatcctctgttatt
gctgacagagtggctctaaagcttgttggtaaacccaagaatgctgacgaaggtgtcgaa
tccggttatgttgttacggaagctggatttgactttaccatgggtggtgagagattcttc
aacatcaagtgcagagcttcagggttaactccaaatgccgtcgttttagttgctaccgtg
agagctctaaaattgcatggtggtgccccagacgtcaagccaggccagtcattacctgaa
gagtacacacaagaaaacgtggagttggtcaagaacggaactgctaacatgtgcaagcaa
atcgaaaacattaaacaattcggtattccagtagttgttgctgtcaacagatttgaatct
gacactgaagccgaaattgatgctatcaaggaagcagcacaaaaagcaggtgcatttgac
gttgtttccacgaaccactgggccgaaggtggtaagggtgccatcaacttggcaaaatct
gtcattgaagcctccaaacaaccttcagacttcaagttcctctacgatgtcaacgacaca
gtggaagagaaactttcaactatcgttacaaagatgtacggtggtgccaagattgagatc
tccgaagaagctcaaaagaaaattgacatgtaccgtgaacaagggtttggtaacctacca
atatgtattgccaagactcagtactcattgtcccacgatgcaaagttaaaaaacgttcca
actgggtttactttcccaattagagacgttagagcatccatcggtgccggatacttgtat
gcactagcagctgaaattcaaacgattccgggtctatcaacccacgccggttacatgaac
gtcgaaatcgacgaagacggtgaaattgaaggtctattctag

DBGET integrated database retrieval system