Homo sapiens (human): 6530
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Entry
6530 CDS
T01001
Symbol
SLC6A2, NAT1, NET, NET1, SLC6A5
Name
(RefSeq) solute carrier family 6 member 2
KO
K05035
solute carrier family 6 (neurotransmitter transporter, noradrenalin) member 2
Organism
hsa
Homo sapiens (human)
Pathway
hsa04721
Synaptic vesicle cycle
Disease
H01031
Orthostatic intolerance
Drug target
Amezinium metilsulfate:
D01304
<JP>
Amfepramone (
DG00104
):
D03801
<US>
D07444
Amfetamine (
DG00966
):
D02074
<US>
D07445
<US>
Amitifadine (
DG01386
):
D10088
D10089
Amitriptyline (
DG00934
):
D00809
<JP/US>
D07448
Amitriptylinoxide:
D07449
Amoxapine:
D00228
<JP/US>
Amphetamine aspartate monohydrate:
D11622
Ampreloxetine (
DG03081
):
D11688
D11689
Atomoxetine (
DG00970
):
D02574
<JP/US>
D07473
Benzfetamine (
DG01755
):
D07514
D07515
<US>
Bupropion (
DG00957
):
D00817
<US>
D07591
D07938
<US>
Centanafadine (
DG01858
):
D10697
D10698
Cidoxepin hydrochloride:
D03491
Clomipramine (
DG00929
):
D00811
<JP/US>
D07727
Cocaine (
DG00808
):
D00110
D02182
<US>
Dasotraline (
DG01989
):
D10700
D10870
Desipramine (
DG00927
):
D00812
<US>
D07791
Desvenlafaxine (
DG00963
):
D02570
<US>
D07793
<US>
D11619
<US>
Dexamfetamine (
DG00967
):
D02078
<US>
D03740
<US>
Dexmethylphenidate (
DG00972
):
D03721
<US>
D07806
Dextroamphetamine saccharate:
D11623
Dosulepin (
DG00940
):
D01546
<JP>
D07872
Doxepin (
DG00937
):
D00814
<US>
D07875
Duloxetine (
DG00962
):
D01179
<JP/US>
D07880
Edivoxetine (
DG01310
):
D09890
D09891
Esreboxetine (
DG01309
):
D09340
D09341
Guanethidine (
DG00258
):
D02237
D04382
D08030
Hydroxyamphetamine hydrobromide:
D04473
Imipramine (
DG00928
):
D00815
<JP/US>
D08070
D08071
<US>
Imipraminoxide (
DG01542
):
D07334
D08072
Indeloxazine (
DG02869
):
D02170
D08077
Levomilnacipran (
DG01387
):
D10072
D10133
<US>
Liafensine:
D10443
Lisdexamfetamine (
DG00973
):
D04747
<JP/US>
D08130
Lofepramine (
DG00932
):
D01285
<JP>
D08140
Lortalamine:
D04781
Maprotiline (
DG00941
):
D00818
<JP>
D02566
Mazindol:
D00367
<JP>
Metamfetamine (
DG00968
):
D02242
<JP/US>
D08187
Methylphenidate (
DG00969
):
D01296
<JP/US>
D04999
<US>
Midomafetamine (
DG03316
):
D11172
D12937
Milnacipran (
DG00960
):
D01107
<JP/US>
D08222
Napamezole hydrochloride:
D05119
Napitane mesylate:
D05120
Nisoxetine:
D05173
Nomifensine:
D05200
Nortriptyline (
DG00935
):
D00816
<JP/US>
D08288
Oxaprotiline hydrochloride:
D05284
Phendimetrazine (
DG01537
):
D02080
<US>
D08347
D08348
Phenmetrazine hydrochloride:
D05454
Phentermine (
DG00102
):
D05458
D05459
<US>
Protriptyline (
DG00936
):
D00484
<US>
D08447
Pyrovalerone hydrochloride:
D05663
Radafaxine hydrochloride:
D05692
Reboxetine (
DG00961
):
D02573
D08472
Sibutramine (
DG00108
):
D02571
D08513
Solriamfetol (
DG02989
):
D11315
D11328
<US>
Talopram hydrochloride:
D05997
Tampramine fumarate:
D02704
Tandamine hydrochloride:
D06004
Tapentadol (
DG00826
):
D06007
D10199
<JP/US>
Tenamfetamine:
D12715
Toludesvenlafaxine (
DG03141
):
D11940
D11941
Trimipramine (
DG00931
):
D00394
D02408
<JP/US>
Venlafaxine (
DG00959
):
D00821
<JP/US>
D08670
D12403
<US>
Viloxazine (
DG00956
):
D02572
<US>
D08673
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09150 Organismal Systems
09156 Nervous system
04721 Synaptic vesicle cycle
6530 (SLC6A2)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
02000 Transporters [BR:
hsa02000
]
6530 (SLC6A2)
Transporters [BR:
hsa02000
]
Solute carrier family (SLC)
SLC6: Sodium- and chloride-dependent neurotransmitter transporter
6530 (SLC6A2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
SNF
Motif
Other DBs
NCBI-GeneID:
6530
NCBI-ProteinID:
NP_001034
OMIM:
163970
HGNC:
11048
Ensembl:
ENSG00000103546
UniProt:
P23975
Structure
PDB
PDBj
LinkDB
All DBs
Position
16:55655988..55706192
Genome browser
AA seq
617 aa
AA seq
DB search
MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWG
KKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYN
REGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTW
NSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLC
LMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFY
RLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFA
IFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSS
MGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTS
ILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINF
KPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHL
VAQRDIRQFQLQHWLAI
NT seq
1854 nt
NT seq
+upstream
nt +downstream
nt
atgcttctggcgcggatgaacccgcaggtgcagcccgagaacaacggggcggacacgggt
ccagagcagccccttcgggcgcgcaaaactgcggagctgctggtggtgaaggagcgcaac
ggcgtccagtgcctgctggcgccccgcgacggcgacgcgcagccccgggagacctggggc
aagaagatcgacttcctgctgtccgtagtcggcttcgcagtggacctggccaacgtgtgg
cgcttcccctacctctgctacaagaacggcggcggtgccttcttgatcccgtacacactg
ttccttatcatcgcggggatgcccctgttctacatggagctggctctgggacagtacaac
cgggagggggctgccaccgtttggaaaatctgcccattcttcaaaggcgttggctatgct
gtcatcctgatcgccctgtacgttggcttctactacaacgtcatcatcgcctggtcactc
tactacctcttctcctccttcaccctcaacctgccctggaccgactgtggccacacctgg
aacagccccaactgtaccgaccccaagctcctcaatggctccgtgcttggcaaccacacc
aagtactccaagtacaagttcacgccggcagccgagttttatgagcgtggtgtcctgcac
cttcacgagagcagcgggattcatgacatcggcctgccccagtggcagctcttgctctgt
ctgatggtcgtcgtcatcgtcttgtattttagcctctggaaaggggtgaagacatcagga
aaggtggtgtggatcacagccacgctgccttacttcgtgctgttcgtgctcctggtccat
ggcgtcacgctgcccggagcctccaatggcatcaatgcctacctgcacatcgacttctac
cgcttgaaagaggccacggtatggattgatgccgcaactcagatatttttttccttgggg
gctggatttggagtattgattgcatttgccagttacaacaaatttgacaacaactgttac
agggatgccctgctgaccagcagcatcaactgtatcaccagcttcgtctctgggttcgcc
atcttctccatccttggttacatggcccatgaacacaaggtcaacattgaggatgtggcc
acagaaggagctggcctagtgttcatcctgtatccagaggccatttctaccctgtctgga
tctacattctgggctgttgtgtttttcgtcatgctcctggcgctgggccttgacagctca
atgggaggcatggaggctgtcatcacgggcctggcagatgacttccaggtcctgaagcga
caccggaaactcttcacatttggcgtcaccttcagcactttccttctcgccctgttctgc
ataaccaagggtggaatttacgtcttgaccctcctggacacctttgctgcgggcacctcc
atcctttttgctgtcctcatggaagccatcggagtttcctggttttatggagtggacagg
ttcagcaacgacatccagcagatgatggggttcaggccgggtctatactggagactgtgc
tggaagttcgtcagtcctgccttcctcctgttcgtggttgtggtcagcatcatcaacttc
aagccactcacctacgacgactacatcttcccgccctgggccaactgggtggggtggggc
atcgccctgtcctccatggtcctggtgcccatctacgtcatctataagttcctcagcacg
cagggctctctttgggagagactggcctatggcatcacgccagagaacgagcaccacctg
gtggctcagagggacatcagacagttccagttgcaacactggctggccatctga
DBGET
integrated database retrieval system
