Entry |
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Symbol |
ROS1, MCF3, ROS, c-ros-1
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Name |
(RefSeq) ROS proto-oncogene 1, receptor tyrosine kinase
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KO |
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Organism |
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Disease |
H00014 | Non-small cell lung cancer |
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Drug target |
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Brite |
KEGG Orthology (KO) [BR:hsa00001]
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:hsa01001]
6098 (ROS1)
Enzymes [BR:hsa01000]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.1 receptor protein-tyrosine kinase
6098 (ROS1)
Protein kinases [BR:hsa01001]
Receptor tyrosine kinases (RTK)
ROS family
6098 (ROS1)
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SSDB |
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Motif |
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Other DBs |
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Structure |
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LinkDB |
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Position |
6:complement(117287353..117425942)
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AA seq |
2347 aa
MKNIYCLIPKLVNFATLGCLWISVVQCTVLNSCLKSCVTNLGQQLDLGTPHNLSEPCIQG
CHFWNSVDQKNCALKCRESCEVGCSSAEGAYEEEVLENADLPTAPFASSIGSHNMTLRWK
SANFSGVKYIIQWKYAQLLGSWTYTKTVSRPSYVVKPLHPFTEYIFRVVWIFTAQLQLYS
PPSPSYRTHPHGVPETAPLIRNIESSSPDTVEVSWDPPQFPGGPILGYNLRLISKNQKLD
AGTQRTSFQFYSTLPNTIYRFSIAAVNEVGEGPEAESSITTSSSAVQQEEQWLFLSRKTS
LRKRSLKHLVDEAHCLRLDAIYHNITGISVDVHQQIVYFSEGTLIWAKKAANMSDVSDLR
IFYRGSGLISSISIDWLYQRMYFIMDELVCVCDLENCSNIEEITPPSISAPQKIVADSYN
GYVFYLLRDGIYRADLPVPSGRCAEAVRIVESCTLKDFAIKPQAKRIIYFNDTAQVFMST
FLDGSASHLILPRIPFADVKSFACENNDFLVTDGKVIFQQDALSFNEFIVGCDLSHIEEF
GFGNLVIFGSSSQLHPLPGRPQELSVLFGSHQALVQWKPPALAIGANVILISDIIELFEL
GPSAWQNWTYEVKVSTQDPPEVTHIFLNISGTMLNVPELQSAMKYKVSVRASSPKRPGPW
SEPSVGTTLVPASEPPFIMAVKEDGLWSKPLNSFGPGEFLSSDIGNVSDMDWYNNSLYYS
DTKGDVFVWLLNGTDISENYHLPSIAGAGALAFEWLGHFLYWAGKTYVIQRQSVLTGHTD
IVTHVKLLVNDMVVDSVGGYLYWTTLYSVESTRLNGESSLVLQTQPWFSGKKVIALTLDL
SDGLLYWLVQDSQCIHLYTAVLRGQSTGDTTITEFAAWSTSEISQNALMYYSGRLFWING
FRIITTQEIGQKTSVSVLEPARFNQFTIIQTSLKPLPGNFSFTPKVIPDSVQESSFRIEG
NASSFQILWNGPPAVDWGVVFYSVEFSAHSKFLASEQHSLPVFTVEGLEPYALFNLSVTP
YTYWGKGPKTSLSLRAPETVPSAPENPRIFILPSGKCCNKNEVVVEFRWNKPKHENGVLT
KFEIFYNISNQSITNKTCEDWIAVNVTPSVMSFQLEGMSPRCFIAFQVRAFTSKGPGPYA
DVVKSTTSEINPFPHLITLLGNKIVFLDMDQNQVVWTFSAERVISAVCYTADNEMGYYAE
GDSLFLLHLHNRSSSELFQDSLVFDITVITIDWISRHLYFALKESQNGMQVFDVDLEHKV
KYPREVKIHNRNSTIISFSVYPLLSRLYWTEVSNFGYQMFYYSIISHTLHRILQPTATNQ
QNKRNQCSCNVTEFELSGAMAIDTSNLEKPLIYFAKAQEIWAMDLEGCQCWRVITVPAML
AGKTLVSLTVDGDLIYWIITAKDSTQIYQAKKGNGAIVSQVKALRSRHILAYSSVMQPFP
DKAFLSLASDTVEPTILNATNTSLTIRLPLAKTNLTWYGITSPTPTYLVYYAEVNDRKNS
SDLKYRILEFQDSIALIEDLQPFSTYMIQIAVKNYYSDPLEHLPPGKEIWGKTKNGVPEA
VQLINTTVRSDTSLIISWRESHKPNGPKESVRYQLAISHLALIPETPLRQSEFPNGRLTL
LVTRLSGGNIYVLKVLACHSEEMWCTESHPVTVEMFNTPEKPYSLVPENTSLQFNWKAPL
NVNLIRFWVELQKWKYNEFYHVKTSCSQGPAYVCNITNLQPYTSYNVRVVVVYKTGENST
SLPESFKTKAGVPNKPGIPKLLEGSKNSIQWEKAEDNGCRITYYILEIRKSTSNNLQNQN
LRWKMTFNGSCSSVCTWKSKNLKGIFQFRVVAANNLGFGEYSGISENIILVGDDFWIPET
SFILTIIVGIFLVVTIPLTFVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLAN
ACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVK
TLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRK
ARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKI
GDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQ
PYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRN
FFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNREGLNYMVLATE
CGQGEEKSEGPLGSQESESCGLRKEEKEPHADKDFCQEKQVAYCPSGKPEGLNYACLTHS
GYGDGSD |
NT seq |
7044 nt +upstreamnt +downstreamnt
atgaagaacatttactgtcttattccgaagcttgtcaattttgcaactcttggctgccta
tggatttctgtggtgcagtgtacagttttaaatagctgcctaaagtcgtgtgtaactaat
ctgggccagcagcttgaccttggcacaccacataatctgagtgaaccgtgtatccaagga
tgtcacttttggaactctgtagatcagaaaaactgtgctttaaagtgtcgggagtcgtgt
gaggttggctgtagcagcgcggaaggtgcatatgaagaggaagtactggaaaatgcagac
ctaccaactgctccctttgcttcttccattggaagccacaatatgacattacgatggaaa
tctgcaaacttctctggagtaaaatacatcattcagtggaaatatgcacaacttctggga
agctggacttatactaagactgtgtccagaccgtcctatgtggtcaagcccctgcacccc
ttcactgagtacattttccgagtggtttggatcttcacagcgcagctgcagctctactcc
cctccaagtcccagttacaggactcatcctcatggagttcctgaaactgcacctttgatt
aggaatattgagagctcaagtcccgacactgtggaagtcagctgggatccacctcaattc
ccaggtggacctattttgggttataacttaaggctgatcagcaaaaatcaaaaattagat
gcagggacacagagaaccagtttccagttttactccactttaccaaatactatctacagg
ttttctattgcagcagtaaatgaagttggtgagggtccagaagcagaatctagtattacc
acttcatcttcagcagttcaacaagaggaacagtggctctttttatccagaaaaacttct
ctaagaaagagatctttaaaacatttagtagatgaagcacattgccttcggttggatgct
atataccataatattacaggaatatctgttgatgtccaccagcaaattgtttatttctct
gaaggaactctcatatgggcgaagaaggctgccaacatgtctgatgtatctgacctgaga
attttttacagaggttcaggattaatttcttctatctccatagattggctttatcaaaga
atgtatttcatcatggatgaactggtatgtgtctgtgatttagagaactgctcaaacatc
gaggaaattactccaccctctattagtgcacctcaaaaaattgtggctgattcatacaat
gggtatgtcttttacctcctgagagatggcatttatagagcagaccttcctgtaccatct
ggccggtgtgcagaagctgtgcgtattgtggagagttgcacgttaaaggactttgcaatc
aagccacaagccaagcgaatcatttacttcaatgacactgcccaagtcttcatgtcaaca
tttctggatggctctgcttcccatctcatcctacctcgcatcccctttgctgatgtgaaa
agttttgcttgtgaaaacaatgactttcttgtcacagatggcaaggtcattttccaacag
gatgctttgtcttttaatgaattcatcgtgggatgtgacctgagtcacatagaagaattt
gggtttggtaacttggtcatctttggctcatcctcccagctgcaccctctgccaggccgc
ccgcaggagctttcggtgctgtttggctctcaccaggctcttgttcaatggaagcctcct
gcccttgccataggagccaatgtcatcctgatcagtgatattattgaactctttgaatta
ggcccttctgcctggcagaactggacctatgaggtgaaagtatccacccaagaccctcct
gaagtcactcatattttcttgaacataagtggaaccatgctgaatgtacctgagctgcag
agtgctatgaaatacaaggtttctgtgagagcaagttctccaaagaggccaggcccctgg
tcagagccctcagtgggtactaccctggtgccagctagtgaaccaccatttatcatggct
gtgaaagaagatgggctttggagtaaaccattaaatagctttggcccaggagagttctta
tcctctgatataggaaatgtgtcagacatggattggtataacaacagcctctactacagt
gacacgaaaggcgacgtttttgtgtggctgctgaatgggacggatatctcagagaattat
cacctacccagcattgcaggagcaggggctttagcttttgagtggctgggtcactttctc
tactgggctggaaagacatatgtgatacaaaggcagtctgtgttgacgggacacacagac
attgttacccacgtgaagctattggtgaatgacatggtggtggattcagttggtggatat
ctctactggaccacactctattcagtggaaagcaccagactaaatggggaaagttccctt
gtactacagacacagccttggttttctgggaaaaaggtaattgctctaactttagacctc
agtgatgggctcctgtattggttggttcaagacagtcaatgtattcacctgtacacagct
gttcttcggggacagagcactggggataccaccatcacagaatttgcagcctggagtact
tctgaaatttcccagaatgcactgatgtactatagtggtcggctgttctggatcaatggc
tttaggattatcacaactcaagaaataggtcagaaaaccagtgtctctgttttggaacca
gccagatttaatcagttcacaattattcagacatcccttaagcccctgccagggaacttt
tcctttacccctaaggttattccagattctgttcaagagtcttcatttaggattgaagga
aatgcttcaagttttcaaatcctgtggaatggtccccctgcggtagactggggtgtagtt
ttctacagtgtagaatttagtgctcattctaagttcttggctagtgaacaacactcttta
cctgtatttactgtggaaggactggaaccttatgccttatttaatctttctgtcactcct
tatacctactggggaaagggccccaaaacatctctgtcacttcgagcacctgaaacagtt
ccatcagcaccagagaaccccagaatatttatattaccaagtggaaaatgctgcaacaag
aatgaagttgtggtggaatttaggtggaacaaacctaagcatgaaaatggggtgttaaca
aaatttgaaattttctacaatatatccaatcaaagtattacaaacaaaacatgtgaagac
tggattgctgtcaatgtcactccctcagtgatgtcttttcaacttgaaggcatgagtccc
agatgctttattgccttccaggttagggcctttacatctaaggggccaggaccatatgct
gacgttgtaaagtctacaacatcagaaatcaacccatttcctcacctcataactcttctt
ggtaacaagatagtttttttagatatggatcaaaatcaagttgtgtggacgttttcagca
gaaagagttatcagtgccgtttgctacacagctgataatgagatgggatattatgctgaa
ggggactcactctttcttctgcacttgcacaatcgctctagctctgagcttttccaagat
tcactggtttttgatatcacagttattacaattgactggatttcaaggcacctctacttt
gcactgaaagaatcacaaaatggaatgcaagtatttgatgttgatcttgaacacaaggtg
aaatatcccagagaggtgaagattcacaataggaattcaacaataatttctttttctgta
tatcctcttttaagtcgcttgtattggacagaagtttccaattttggctaccagatgttc
tactacagtattatcagtcacaccttgcaccgaattctgcaacccacagctacaaaccaa
caaaacaaaaggaatcaatgttcttgtaatgtgactgaatttgagttaagtggagcaatg
gctattgatacctctaacctagagaaaccattgatatactttgccaaagcacaagagatc
tgggcaatggatctggaaggctgtcagtgttggagagttatcacagtacctgctatgctc
gcaggaaaaacccttgttagcttaactgtggatggagatcttatatactggatcatcaca
gcaaaggacagcacacagatttatcaggcaaagaaaggaaatggggccatcgtttcccag
gtgaaggccctaaggagtaggcatatcttggcttacagttcagttatgcagccttttcca
gataaagcgtttctgtctctagcttcagacactgtggaaccaactatacttaatgccact
aacactagcctcacaatcagattacctctggccaagacaaacctcacatggtatggcatc
accagccctactccaacatacctggtttattatgcagaagttaatgacaggaaaaacagc
tctgacttgaaatatagaattctggaatttcaggacagtatagctcttattgaagattta
caaccattttcaacatacatgatacagatagctgtaaaaaattattattcagatcctttg
gaacatttaccaccaggaaaagagatttggggaaaaactaaaaatggagtaccagaggca
gtgcagctcattaatacaactgtgcggtcagacaccagcctcattatatcttggagagaa
tctcacaagccaaatggacctaaagaatcagtccgttatcagttggcaatctcacacctg
gccctaattcctgaaactcctctaagacaaagtgaatttccaaatggaaggctcactctc
cttgttactagactgtctggtggaaatatttatgtgttaaaggttcttgcctgccactct
gaggaaatgtggtgtacagagagtcatcctgtcactgtggaaatgtttaacacaccagag
aaaccttattccttggttccagagaacactagtttgcaatttaattggaaggctccattg
aatgttaacctcatcagattttgggttgagctacagaagtggaaatacaatgagttttac
catgttaaaacttcatgcagccaaggtcctgcttatgtctgtaatatcacaaatctacaa
ccttatacttcatataatgtcagagtagtggtggtttataagacgggagaaaatagcacc
tcacttccagaaagctttaagacaaaagctggagtcccaaataaaccaggcattcccaaa
ttactagaagggagtaaaaattcaatacagtgggagaaagctgaagataatggatgtaga
attacatactatatccttgagataagaaagagcacttcaaataatttacagaaccagaat
ttaaggtggaagatgacatttaatggatcctgcagtagtgtttgcacatggaagtccaaa
aacctgaaaggaatatttcagttcagagtagtagctgcaaataatctagggtttggtgaa
tatagtggaatcagtgagaatattatattagttggagatgatttttggataccagaaaca
agtttcatacttactattatagttggaatatttctggttgttacaatcccactgaccttt
gtctggcatagaagattaaagaatcaaaaaagtgccaaggaaggggtgacagtgcttata
aacgaagacaaagagttggctgagctgcgaggtctggcagccggagtaggcctggctaat
gcctgctatgcaatacatactcttccaacccaagaggagattgaaaatcttcctgccttc
cctcgggaaaaactgactctgcgtctcttgctgggaagtggagcctttggagaagtgtat
gaaggaacagcagtggacatcttaggagttggaagtggagaaatcaaagtagcagtgaag
actttgaagaagggttccacagaccaggagaagattgaattcctgaaggaggcacatctg
atgagcaaatttaatcatcccaacattctgaagcagcttggagtttgtctgctgaatgaa
ccccaatacattatcctggaactgatggagggaggagaccttcttacttatttgcgtaaa
gcccggatggcaacgttttatggtcctttactcaccttggttgaccttgtagacctgtgt
gtagatatttcaaaaggctgtgtctacttggaacggatgcatttcattcacagggatctg
gcagctagaaattgccttgtttccgtgaaagactataccagtccacggatagtgaagatt
ggagactttggactcgccagagacatctataaaaatgattactatagaaagagaggggaa
ggcctgctcccagttcggtggatggctccagaaagtttgatggatggaatcttcactact
caatctgatgtatggtcttttggaattctgatttgggagattttaactcttggtcatcag
ccttatccagctcattccaaccttgatgtgttaaactatgtgcaaacaggagggagactg
gagccaccaagaaattgtcctgatgatctgtggaatttaatgacccagtgctgggctcaa
gaacccgaccaaagacctacttttcatagaattcaggaccaacttcagttattcagaaat
tttttcttaaatagcatttataagtccagagatgaagcaaacaacagtggagtcataaat
gaaagctttgaaggtgaagatggcgatgtgatttgtttgaattcagatgacattatgcca
gttgctttaatggaaacgaagaaccgagaagggttaaactatatggtacttgctacagaa
tgtggccaaggtgaagaaaagtctgagggtcctctaggctcccaggaatctgaatcttgt
ggtctgaggaaagaagagaaggaaccacatgcagacaaagatttctgccaagaaaaacaa
gtggcttactgcccttctggcaagcctgaaggcctgaactatgcctgtctcactcacagt
ggatatggagatgggtctgattaa |