Entry |
|
Symbol |
SRC, ASV, SRC1, THC6, c-SRC, p60-Src
|
Name |
(RefSeq) SRC proto-oncogene, non-receptor tyrosine kinase
|
KO |
|
Organism |
|
Pathway |
hsa01521 | EGFR tyrosine kinase inhibitor resistance |
hsa04613 | Neutrophil extracellular trap formation |
hsa04625 | C-type lectin receptor signaling pathway |
hsa04750 | Inflammatory mediator regulation of TRP channels |
hsa04810 | Regulation of actin cytoskeleton |
hsa04919 | Thyroid hormone signaling pathway |
hsa05100 | Bacterial invasion of epithelial cells |
hsa05120 | Epithelial cell signaling in Helicobacter pylori infection |
hsa05130 | Pathogenic Escherichia coli infection |
hsa05163 | Human cytomegalovirus infection |
hsa05167 | Kaposi sarcoma-associated herpesvirus infection |
hsa05168 | Herpes simplex virus 1 infection |
hsa05207 | Chemical carcinogenesis - receptor activation |
hsa05208 | Chemical carcinogenesis - reactive oxygen species |
hsa05418 | Fluid shear stress and atherosclerosis |
|
Network |
|
Element |
N00393 | ITGA/B-RhoGAP-RhoA signaling pathway |
N00394 | HCMV gH to ITGA/B-RhoA signaling pathway |
N00538 | Ca2+-PYK2-RAS-ERK signaling pathway |
N00540 | HBV HBx to RAS-ERK signaling pathway |
N01068 | ITGA/B-FAK-RAC signaling pathway |
N01070 | ITGA/B-FAK-CDC42 signaling pathway |
N01078 | EGF-EGFR-Actin signaling pathway |
N01079 | Shigella IpaC to Actin signaling pathway |
N01091 | Escherichia EspJ to IGG-FCGR-RAC signaling pathway |
N01336 | CHRNA7-E2F signaling pathway |
N01337 | NNK/NNN to CHRNA7-E2F signaling pathway |
N01351 | E2-ER-RAS-ERK signaling pathway |
N01352 | BPA to RAS-ERK signaling pathway |
N01353 | E2 to RAS-ERK signaling pathway |
N01358 | P4-PR-PI3K signaling pathway |
N01359 | P4/MPA to PR-PI3K signaling pathway |
N01360 | P4-PR-RAS-ERK signaling pathway |
N01361 | P4/MPA to PR-RAS-ERK signaling pathway |
N01411 | Metals to NFKB signaling pathway |
N01767 | CXCR4-GNAI-Src signaling pathway |
N01838 | Regulation of synaptic plasticity, p140Cap |
|
Disease |
|
Drug target |
|
Brite |
KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
09132 Signal transduction
04015 Rap1 signaling pathway
6714 (SRC)
09133 Signaling molecules and interaction
04081 Hormone signaling
6714 (SRC)
09140 Cellular Processes
09141 Transport and catabolism
04144 Endocytosis
6714 (SRC)
04137 Mitophagy - animal
6714 (SRC)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
6714 (SRC)
04613 Neutrophil extracellular trap formation
6714 (SRC)
04062 Chemokine signaling pathway
6714 (SRC)
09152 Endocrine system
04915 Estrogen signaling pathway
6714 (SRC)
04917 Prolactin signaling pathway
6714 (SRC)
04921 Oxytocin signaling pathway
6714 (SRC)
04926 Relaxin signaling pathway
6714 (SRC)
04919 Thyroid hormone signaling pathway
6714 (SRC)
09156 Nervous system
04727 GABAergic synapse
6714 (SRC)
09157 Sensory system
04750 Inflammatory mediator regulation of TRP channels
6714 (SRC)
09158 Development and regeneration
04360 Axon guidance
6714 (SRC)
09160 Human Diseases
09161 Cancer: overview
05205 Proteoglycans in cancer
6714 (SRC)
05207 Chemical carcinogenesis - receptor activation
6714 (SRC)
05208 Chemical carcinogenesis - reactive oxygen species
6714 (SRC)
05203 Viral carcinogenesis
6714 (SRC)
09162 Cancer: specific types
05219 Bladder cancer
6714 (SRC)
09172 Infectious disease: viral
05161 Hepatitis B
6714 (SRC)
05163 Human cytomegalovirus infection
6714 (SRC)
05167 Kaposi sarcoma-associated herpesvirus infection
6714 (SRC)
09171 Infectious disease: bacterial
05120 Epithelial cell signaling in Helicobacter pylori infection
6714 (SRC)
05130 Pathogenic Escherichia coli infection
6714 (SRC)
05131 Shigellosis
6714 (SRC)
05135 Yersinia infection
6714 (SRC)
05152 Tuberculosis
6714 (SRC)
05100 Bacterial invasion of epithelial cells
6714 (SRC)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
6714 (SRC)
05418 Fluid shear stress and atherosclerosis
6714 (SRC)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
6714 (SRC)
01522 Endocrine resistance
6714 (SRC)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:hsa01001]
6714 (SRC)
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:hsa04131]
6714 (SRC)
Enzymes [BR:hsa01000]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.2 non-specific protein-tyrosine kinase
6714 (SRC)
Protein kinases [BR:hsa01001]
Non-receptor tyrosine kinases
SRC family
6714 (SRC)
Membrane trafficking [BR:hsa04131]
Exocytosis
Calcium ion-dependent exocytosis
Kinases and associated proteins
6714 (SRC)
Endocytosis
Clathrin-mediated endocytosis
Kinases
6714 (SRC)
Lipid raft mediated endocytosis
Caveolin-mediated endocytosis
6714 (SRC)
Macropinocytosis
Kinases
6714 (SRC)
|
SSDB |
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Motif |
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Other DBs |
|
Structure |
|
LinkDB |
|
Position |
20:37344699..37406050
|
AA seq |
536 aa
MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAE
PKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGD
WWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRES
ETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGL
CHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTL
KPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKY
LRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYT
ARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER
GYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL |
NT seq |
1611 nt +upstreamnt +downstreamnt
atgggtagcaacaagagcaagcccaaggatgccagccagcggcgccgcagcctggagccc
gccgagaacgtgcacggcgctggcgggggcgctttccccgcctcgcagacccccagcaag
ccagcctcggccgacggccaccgcggccccagcgcggccttcgcccccgcggccgccgag
cccaagctgttcggaggcttcaactcctcggacaccgtcacctccccgcagagggcgggc
ccgctggccggtggagtgaccacctttgtggccctctatgactatgagtctaggacggag
acagacctgtccttcaagaaaggcgagcggctccagattgtcaacaacacagagggagac
tggtggctggcccactcgctcagcacaggacagacaggctacatccccagcaactacgtg
gcgccctccgactccatccaggctgaggagtggtattttggcaagatcaccagacgggag
tcagagcggttactgctcaatgcagagaacccgagagggaccttcctcgtgcgagaaagt
gagaccacgaaaggtgcctactgcctctcagtgtctgacttcgacaacgccaagggcctc
aacgtgaagcactacaagatccgcaagctggacagcggcggcttctacatcacctcccgc
acccagttcaacagcctgcagcagctggtggcctactactccaaacacgccgatggcctg
tgccaccgcctcaccaccgtgtgccccacgtccaagccgcagactcagggcctggccaag
gatgcctgggagatccctcgggagtcgctgcggctggaggtcaagctgggccagggctgc
tttggcgaggtgtggatggggacctggaacggtaccaccagggtggccatcaaaaccctg
aagcctggcacgatgtctccagaggccttcctgcaggaggcccaggtcatgaagaagctg
aggcatgagaagctggtgcagttgtatgctgtggtttcagaggagcccatttacatcgtc
acggagtacatgagcaaggggagtttgctggactttctcaagggggagacaggcaagtac
ctgcggctgcctcagctggtggacatggctgctcagatcgcctcaggcatggcgtacgtg
gagcggatgaactacgtccaccgggaccttcgtgcagccaacatcctggtgggagagaac
ctggtgtgcaaagtggcggactttgggctggctcggctcattgaagacaatgagtacacg
gcgcggcaaggtgccaaattccccatcaagtggacggctccagaagctgccctctatggc
cgcttcaccatcaagtcggacgtgtggtccttcgggatcctgctgactgagctcaccaca
aagggacgggtgccctaccctgggatggtgaaccgcgaggtgctggaccaggtggagcgg
ggctaccggatgccctgcccgccggagtgtcccgagtccctgcacgacctcatgtgccag
tgctggcggaaggagcctgaggagcggcccaccttcgagtacctgcaggccttcctggag
gactacttcacgtccaccgagccccagtaccagcccggggagaacctctag |