Homo sapiens (human): 4669
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Entry
4669 CDS
T01001
Symbol
NAGLU, CMT2V, MPS-IIIB, MPS3B, NAG, UFHSD
Name
(RefSeq) N-acetyl-alpha-glucosaminidase
KO
K01205
alpha-N-acetylglucosaminidase [EC:
3.2.1.50
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00531
Glycosaminoglycan degradation
hsa01100
Metabolic pathways
hsa04142
Lysosome
Module
hsa_M00078
Heparan sulfate degradation
Network
nt06012
Glycosaminoglycan degradation
Element
N00615
Heparan sulfate degradation
Disease
H00130
Mucopolysaccharidosis type III
H00264
Charcot-Marie-Tooth disease
H00421
Mucopolysaccharidosis
Drug target
Lesinidase alfa:
D11199
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09107 Glycan biosynthesis and metabolism
00531 Glycosaminoglycan degradation
4669 (NAGLU)
09140 Cellular Processes
09141 Transport and catabolism
04142 Lysosome
4669 (NAGLU)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
hsa04147
]
4669 (NAGLU)
Enzymes [BR:
hsa01000
]
3. Hydrolases
3.2 Glycosylases
3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
3.2.1.50 alpha-N-acetylglucosaminidase
4669 (NAGLU)
Exosome [BR:
hsa04147
]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
4669 (NAGLU)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
NAGLU
NAGLU_C
NAGLU_N
DUF6725
Motif
Other DBs
NCBI-GeneID:
4669
NCBI-ProteinID:
NP_000254
OMIM:
609701
HGNC:
7632
Ensembl:
ENSG00000108784
UniProt:
P54802
A0A140VJE4
Structure
PDB
PDBj
LinkDB
All DBs
Position
17:42536241..42544449
Genome browser
AA seq
743 aa
AA seq
DB search
MEAVAVAAAVGVLLLAGAGGAAGDEAREAAAVRALVARLLGPGPAADFSVSVERALAAKP
GLDTYSLGGGGAARVRVRGSTGVAAAAGLHRYLRDFCGCHVAWSGSQLRLPRPLPAVPGE
LTEATPNRYRYYQNVCTQSYSFVWWDWARWEREIDWMALNGINLALAWSGQEAIWQRVYL
ALGLTQAEINEFFTGPAFLAWGRMGNLHTWDGPLPPSWHIKQLYLQHRVLDQMRSFGMTP
VLPAFAGHVPEAVTRVFPQVNVTKMGSWGHFNCSYSCSFLLAPEDPIFPIIGSLFLRELI
KEFGTDHIYGADTFNEMQPPSSEPSYLAAATTAVYEAMTAVDTEAVWLLQGWLFQHQPQF
WGPAQIRAVLGAVPRGRLLVLDLFAESQPVYTRTASFQGQPFIWCMLHNFGGNHGLFGAL
EAVNGGPEAARLFPNSTMVGTGMAPEGISQNEVVYSLMAELGWRKDPVPDLAAWVTSFAA
RRYGVSHPDAGAAWRLLLRSVYNCSGEACRGHNRSPLVRRPSLQMNTSIWYNRSDVFEAW
RLLLTSAPSLATSPAFRYDLLDLTRQAVQELVSLYYEEARSAYLSKELASLLRAGGVLAY
ELLPALDEVLASDSRFLLGSWLEQARAAAVSEAEADFYEQNSRYQLTLWGPEGNILDYAN
KQLAGLVANYYTPRWRLFLEALVDSVAQGIPFQQHQFDKNVFQLEQAFVLSKQRYPSQPR
GDTVDLAKKIFLKYYPRWVAGSW
NT seq
2232 nt
NT seq
+upstream
nt +downstream
nt
atggaggcggtggcggtggccgcggcggtgggggtccttctcctggccggggccgggggc
gcggcaggcgacgaggcccgggaggcggcggccgtgcgggcgctcgtggcccggctgctg
gggccaggccccgcggccgacttctccgtgtcggtggagcgcgctctggctgccaagccg
ggcttggacacctacagcctgggcggcggcggcgcggcgcgcgtgcgggtgcgcggctcc
acgggcgtggcggccgccgcggggctgcaccgctacctgcgcgacttctgtggctgccac
gtggcctggtccggctctcagctgcgcctgccgcggccactgccagccgtgccgggggag
ctgaccgaggccacgcccaacaggtaccgctattaccagaatgtgtgcacgcaaagctac
tctttcgtgtggtgggactgggcccgctgggagcgagagatagactggatggcgctgaat
ggcatcaacctggcactggcctggagcggccaggaggccatctggcagcgggtgtacctg
gccttgggcctgacccaggcagagatcaatgagttctttactggtcctgccttcctggcc
tgggggcgaatgggcaacctgcacacctgggatggccccctgcccccctcctggcacatc
aagcagctttacctgcagcaccgggtcctggaccagatgcgctccttcggcatgacccca
gtgctgcctgcattcgcggggcatgttcccgaggctgtcaccagggtgttccctcaggtc
aatgtcacgaagatgggcagttggggccactttaactgttcctactcctgctccttcctt
ctggctccggaagaccccatattccccatcatcgggagcctcttcctgcgagagctgatc
aaagagtttggcacagaccacatctatggggccgacactttcaatgagatgcagccacct
tcctcagagccctcctaccttgccgcagccaccactgccgtctatgaggccatgactgca
gtggatactgaggctgtgtggctgctccaaggctggctcttccagcaccagccgcagttc
tgggggcccgcccagatcagggctgtgctgggagctgtgccccgtggccgcctcctggtt
ctggacctgtttgctgagagccagcctgtgtatacccgcactgcctccttccagggccag
cccttcatctggtgcatgctgcacaactttgggggaaaccatggtctttttggagcccta
gaggctgtgaacggaggcccagaagctgcccgcctcttccccaactccaccatggtaggc
acgggcatggcccccgagggcatcagccagaacgaagtggtctattccctcatggctgag
ctgggctggcgaaaggacccagtgccagatttggcagcctgggtgaccagctttgccgcc
cggcggtatggggtctcccacccggacgcaggggcagcgtggaggctactgctccggagt
gtgtacaactgctccggggaggcctgcaggggccacaatcgtagcccgctggtcaggcgg
ccgtccctacagatgaataccagcatctggtacaaccgatctgatgtgtttgaggcctgg
cggctgctgctcacatctgctccctccctggccaccagccccgccttccgctacgacctg
ctggacctcactcggcaggcagtgcaggagctggtcagcttgtactatgaggaggcaaga
agcgcctacctgagcaaggagctggcctccctgttgagggctggaggcgtcctggcctat
gagctgctgccggcactggacgaggtgctggctagtgacagccgcttcttgctgggcagc
tggctagagcaggcccgagcagcggcagtcagtgaggccgaggccgatttctacgagcag
aacagccgctaccagctgaccttgtgggggccagaaggcaacatcctggactatgccaac
aagcagctggcggggttggtggccaactactacacccctcgctggcggcttttcctggag
gcgctggttgacagtgtggcccagggcatccctttccaacagcaccagtttgacaaaaat
gtcttccaactggagcaggccttcgttctcagcaagcagaggtaccccagccagccgcga
ggagacactgtggacctggccaagaagatcttcctcaaatattacccccgctgggtggcc
ggctcttggtga
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