KEGG T01001: 2346

Homo sapiens (human): 2346

Entry

2346              CDS       T01001

Symbol

FOLH1, FGCP, FOLH, GCP2, GCPII, NAALAD1, PSM, PSMA, mGCP

Name

(RefSeq) folate hydrolase 1

K14592

glutamate carboxypeptidase II (folate hydrolase 1) [EC:3.4.17.21]

Organism

hsa Homo sapiens (human)

Pathway

hsa00250

Alanine, aspartate and glutamate metabolism

hsa01100

Metabolic pathways

hsa04977

Vitamin digestion and absorption

hsa04981

Folate transport and metabolism

Drug target

Acapatamab:

D12121

Capromab pendetide:

D03372

Flotufolastat F18 gallium:

D12606<US>

Gallium (68Ga) gozetotide:

D12257<US>

Indium (111In) capromab pendetide:

D04525

Iofolastat I 123:

D10070

Lutetium (177Lu) vipivotide tetraxetan:

D12335<US>

Nezastomig:

D12566

Piflufolastat (18F):

D12132<US>

Technetium (99mTc) trofolastat chloride:

D10683

Brite

KEGG Orthology (KO) [BR:hsa00001]
09100 Metabolism
  09105 Amino acid metabolism
   00250 Alanine, aspartate and glutamate metabolism
    2346 (FOLH1)
09150 Organismal Systems
  09154 Digestive system
   04977 Vitamin digestion and absorption
    2346 (FOLH1)
   04981 Folate transport and metabolism
    2346 (FOLH1)
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    2346 (FOLH1)
Enzymes [BR:hsa01000]
3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.17  Metallocarboxypeptidases
    3.4.17.21  glutamate carboxypeptidase II
     2346 (FOLH1)
Peptidases and inhibitors [BR:hsa01002]
Metallo peptidases
  Family M28: aminopeptidase Y family
   2346 (FOLH1)

SSDB

Motif

Pfam:

TFR_dimer Peptidase_M28 PA

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

LinkDB

Position

11:complement(49145092..49208602)

AA seq 750 aa
MWNLLHETDSAVATARRPRWLCAGALVLAGGFFLLGFLFGWFIKSSNEATNITPKHNMKA
FLDELKAENIKKFLYNFTQIPHLAGTEQNFQLAKQIQSQWKEFGLDSVELAHYDVLLSYP
NKTHPNYISIINEDGNEIFNTSLFEPPPPGYENVSDIVPPFSAFSPQGMPEGDLVYVNYA
RTEDFFKLERDMKINCSGKIVIARYGKVFRGNKVKNAQLAGAKGVILYSDPADYFAPGVK
SYPDGWNLPGGGVQRGNILNLNGAGDPLTPGYPANEYAYRRGIAEAVGLPSIPVHPIGYY
DAQKLLEKMGGSAPPDSSWRGSLKVPYNVGPGFTGNFSTQKVKMHIHSTNEVTRIYNVIG
TLRGAVEPDRYVILGGHRDSWVFGGIDPQSGAAVVHEIVRSFGTLKKEGWRPRRTILFAS
WDAEEFGLLGSTEWAEENSRLLQERGVAYINADSSIEGNYTLRVDCTPLMYSLVHNLTKE
LKSPDEGFEGKSLYESWTKKSPSPEFSGMPRISKLGSGNDFEVFFQRLGIASGRARYTKN
WETNKFSGYPLYHSVYETYELVEKFYDPMFKYHLTVAQVRGGMVFELANSIVLPFDCRDY
AVVLRKYADKIYSISMKHPQEMKTYSVSFDSLFSAVKNFTEIASKFSERLQDFDKSNPIV
LRMMNDQLMFLERAFIDPLGLPDRPFYRHVIYAPSSHNKYAGESFPGIYDALFDIESKVD
PSKAWGEVKRQIYVAAFTVQAAAETLSEVA

NT seq 2253 nt +upstreamnt +downstreamnt
atgtggaatctccttcacgaaaccgactcggctgtggccaccgcgcgccgcccgcgctgg
ctgtgcgctggggcgctggtgctggcgggtggcttctttctcctcggcttcctcttcggg
tggtttataaaatcctccaatgaagctactaacattactccaaagcataatatgaaagca
tttttggatgaattgaaagctgagaacatcaagaagttcttatataattttacacagata
ccacatttagcaggaacagaacaaaactttcagcttgcaaagcaaattcaatcccagtgg
aaagaatttggcctggattctgttgagctagcacattatgatgtcctgttgtcctaccca
aataagactcatcccaactacatctcaataattaatgaagatggaaatgagattttcaac
acatcattatttgaaccacctcctccaggatatgaaaatgtttcggatattgtaccacct
ttcagtgctttctctcctcaaggaatgccagagggcgatctagtgtatgttaactatgca
cgaactgaagacttctttaaattggaacgggacatgaaaatcaattgctctgggaaaatt
gtaattgccagatatgggaaagttttcagaggaaataaggttaaaaatgcccagctggca
ggggccaaaggagtcattctctactccgaccctgctgactactttgctcctggggtgaag
tcctatccagatggttggaatcttcctggaggtggtgtccagcgtggaaatatcctaaat
ctgaatggtgcaggagaccctctcacaccaggttacccagcaaatgaatatgcttatagg
cgtggaattgcagaggctgttggtcttccaagtattcctgttcatccaattggatactat
gatgcacagaagctcctagaaaaaatgggtggctcagcaccaccagatagcagctggaga
ggaagtctcaaagtgccctacaatgttggacctggctttactggaaacttttctacacaa
aaagtcaagatgcacatccactctaccaatgaagtgacaagaatttacaatgtgataggt
actctcagaggagcagtggaaccagacagatatgtcattctgggaggtcaccgggactca
tgggtgtttggtggtattgaccctcagagtggagcagctgttgttcatgaaattgtgagg
agctttggaacactgaaaaaggaagggtggagacctagaagaacaattttgtttgcaagc
tgggatgcagaagaatttggtcttcttggttctactgagtgggcagaggagaattcaaga
ctccttcaagagcgtggcgtggcttatattaatgctgactcatctatagaaggaaactac
actctgagagttgattgtacaccgctgatgtacagcttggtacacaacctaacaaaagag
ctgaaaagccctgatgaaggctttgaaggcaaatctctttatgaaagttggactaaaaaa
agtccttccccagagttcagtggcatgcccaggataagcaaattgggatctggaaatgat
tttgaggtgttcttccaacgacttggaattgcttcaggcagagcacggtatactaaaaat
tgggaaacaaacaaattcagcggctatccactgtatcacagtgtctatgaaacatatgag
ttggtggaaaagttttatgatccaatgtttaaatatcacctcactgtggcccaggttcga
ggagggatggtgtttgagctagccaattccatagtgctcccttttgattgtcgagattat
gctgtagttttaagaaagtatgctgacaaaatctacagtatttctatgaaacatccacag
gaaatgaagacatacagtgtatcatttgattcacttttttctgcagtaaagaattttaca
gaaattgcttccaagttcagtgagagactccaggactttgacaaaagcaacccaatagta
ttaagaatgatgaatgatcaactcatgtttctggaaagagcatttattgatccattaggg
ttaccagacaggcctttttataggcatgtcatctatgctccaagcagccacaacaagtat
gcaggggagtcattcccaggaatttatgatgctctgtttgatattgaaagcaaagtggac
ccttccaaggcctggggagaagtgaagagacagatttatgttgcagccttcacagtgcag
gcagctgcagagactttgagtgaagtagcctaa

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