KEGG   Heterocephalus glaber (naked mole-rat): 101721263
Entry
101721263         CDS       T02812                                 
Symbol
Tyms
Name
(RefSeq) thymidylate synthetase
  KO
K00560  thymidylate synthase [EC:2.1.1.45]
Organism
hgl  Heterocephalus glaber (naked mole-rat)
Pathway
hgl00240  Pyrimidine metabolism
hgl00670  One carbon pool by folate
hgl01100  Metabolic pathways
hgl01232  Nucleotide metabolism
hgl01523  Antifolate resistance
hgl04981  Folate transport and metabolism
Module
hgl_M00938  Pyrimidine deoxyribonucleotide biosynthesis, UDP => dTTP
Brite
KEGG Orthology (KO) [BR:hgl00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00240 Pyrimidine metabolism
    101721263 (Tyms)
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    101721263 (Tyms)
 09150 Organismal Systems
  09154 Digestive system
   04981 Folate transport and metabolism
    101721263 (Tyms)
 09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    101721263 (Tyms)
Enzymes [BR:hgl01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.45  thymidylate synthase
     101721263 (Tyms)
SSDB
Motif
Pfam: Thymidylat_synt
Other DBs
NCBI-GeneID: 101721263
NCBI-ProteinID: XP_004853235
UniProt: A0A0P6J905
LinkDB
Position
Un
AA seq 310 aa
MPAPGSQLPPPPAAHDQGAKPSAPHAELQYLRQVEHILQSGFRKEDRTGTGTLSLFGMQA
RYSLRDQFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLGF
SSRQEGDLGPVYGFQWRHFGADYKDMDSDYSGQGVDQLQKVIDTIKTNPDDRRIIMCAWN
PKDLPLMALPPCHALCQFYVVNGELSCQLYQRSGDMGLGVPFNIASYALLTYMVAHVTGL
QPGDFVHTLGDAHIYLNHIEPLKTQLQREPRPFPKLKILRTVETIDNFTAEDFQLEGYNP
HPAIKMEMAV
NT seq 933 nt   +upstreamnt  +downstreamnt
atgcccgcccccggctctcagctcccgccaccgcccgccgcgcacgaccagggcgcgaag
ccctcggcgccgcacgcggagctgcagtacctgcggcaggtggagcacatcctgcagagc
ggctttcgcaaggaggaccgcacgggcaccgggacgctgtcgctgttcggcatgcaggcg
cgctacagcctgcgagatcagtttcccctgctgaccaccaagcgtgtgttctggaagggt
gttttggaggagctgctgtggtttatcaagggatccacaaacgccaaagaactgtcttcc
aagggcgtgaagatctgggatgccaatgggtcccgagacttcctggacagcctggggttt
tccagccgccaggaaggggacctgggtcccgtgtatggcttccagtggaggcattttggg
gctgactacaaagatatggactcagattactcgggtcagggagtggaccagctgcagaaa
gtgattgacaccatcaaaaccaaccctgatgacagaagaatcatcatgtgcgcctggaac
ccaaaagacctccctctgatggcgctgcctccctgccatgccctctgccagttctacgtg
gtgaacggagagctgtcctgccagctgtaccagcgctccggggacatgggcctgggcgtg
cccttcaacattgccagctacgccctgctcacctacatggtcgcccacgtcactggcctg
cagccaggtgactttgtacatactttgggagatgcacatatttacctgaatcacattgag
ccactgaaaactcagcttcagcgagaaccaagacctttcccaaagctcaaaatccttcga
acagttgagaccatcgacaacttcacagctgaagactttcagctggaagggtacaatcca
catcctgccattaagatggaaatggctgtgtag

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