KEGG   Drosophila melanogaster (fruit fly): Dmel_CG4067
Entry
Dmel_CG4067       CDS       T00030                                 
Symbol
pug
Name
(RefSeq) pugilist, isoform D
  KO
K00288  methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase [EC:1.5.1.5 3.5.4.9 6.3.4.3]
Organism
dme  Drosophila melanogaster (fruit fly)
Pathway
dme00670  One carbon pool by folate
dme01100  Metabolic pathways
dme01240  Biosynthesis of cofactors
dme04981  Folate transport and metabolism
Module
dme_M00141  C1-unit interconversion, eukaryotes
Brite
KEGG Orthology (KO) [BR:dme00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    Dmel_CG4067 (pug)
 09150 Organismal Systems
  09154 Digestive system
   04981 Folate transport and metabolism
    Dmel_CG4067 (pug)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:dme04147]
    Dmel_CG4067 (pug)
Enzymes [BR:dme01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.5  methylenetetrahydrofolate dehydrogenase (NADP+)
     Dmel_CG4067 (pug)
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.4  In cyclic amidines
    3.5.4.9  methenyltetrahydrofolate cyclohydrolase
     Dmel_CG4067 (pug)
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.4  Other carbon-nitrogen ligases
    6.3.4.3  formate---tetrahydrofolate ligase
     Dmel_CG4067 (pug)
Exosome [BR:dme04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   Dmel_CG4067 (pug)
SSDB
Motif
Pfam: FTHFS THF_DHG_CYH_C THF_DHG_CYH AcetDehyd-dimer Peptidase_C39
Other DBs
NCBI-GeneID: 41279
NCBI-ProteinID: NP_001014614
FlyBase: FBgn0020385
UniProt: O96553 E8NH74
LinkDB
Position
3R
AA seq 968 aa
MSAQYQRFLKVLEKWPAEKSKVGSGEWTAEPAIKMSGAKIISGTAVAKSIREELRNEVTA
MSKQLADFVPGLRIVQVGGREDSNVYIRMKIKAATEIGIDAAHVQLPRSITEVELLDKIN
DLNEDPRVHGIIVQMPLDCDTPIDSHRITDAVSPEKDVDGLHTVNEGRLAIGDLGGFLPC
TPWGCLELIRRSGVEIAGARAVVLGRSKIVGTPAAELLKWANATVTVCHSKTRNLEEITR
SADILVVGIGVAEMVKGSWIKPGAVVIDCGINVKPDASKASGSKLVGDVDYAEALQVAGH
LTPVPGGVGPMTVAMLMKNTVRSAARFLERLAKSQWALQTLPLKPQRPVPSDIVIARAQK
PKDIAVLAKEIGLEAREVSLYGNKKAKISLSVLERLKDKEVGHYVVVAGMTPTPLGEGKT
TTLMGLVQALGAHKLRNTMAALRQPSQGPTFGIKGGAAGGGYAQVIPMEEFNLHLTGDIH
AVSAANNLLAAQLDTRIFHENTQKDKALYDRLVPAIKGQRKFSPIQLRRLQKLGITKTDP
DTLTADEYGPFARLDIDPDTIMWERVVDINDRYLRTITVGQSPTEKGISRETRFSISVAS
EIMAVLALSRSLEDMKQRLADMVVAFDKRGKPVTADDLGVTGALAVLLKDALEPNLMQSL
EGTPVLVHAGPFANIAHGCNSIIADEVGLKLVGKNGFVCTEAGFGSDIGMEKFCNIKCRT
SGRKPNAMVLVATVRAIKMHGGGAPVTPGAPLNKQYTEENLELVQKGLPNLLQHIENGKA
FGMPVVVSLNAHSADTPAEHELVKKAALEAGAFAAVVSTHWADGGAGAVQLADAVIKACE
QGNQFRLLYDLELPLVDKMNKIATTMYGAGKVVLSPAAEEKVKRLTDAGFGNLPICMSKV
SGSFTGDAKIKGAPKGFTLDVEDVYVSAGAGFVVAMCGEVTKMPGLPTRPAIYDIDLNTE
TGEIEGLF
NT seq 2907 nt   +upstreamnt  +downstreamnt
atgtcggcgcaatatcaaagattcctgaaagtactagaaaagtggccagcggagaaatca
aaagtcggcagcggagagtggacagcagagccggctatcaagatgagtggggccaagatc
atatcgggcacggcggtggccaaatccattcgcgaagagctgcgtaacgaggtgacggct
atgagcaagcaattggcggattttgtgcccggcttaaggattgtccaggttggtggacgt
gaggactccaacgtttacatccgcatgaagatcaaggcggctacggagatcggtatcgat
gccgcccacgtccagctgccccgatccatcaccgaggtggaattgctcgataagataaac
gatctgaacgaggacccccgggtgcacggcatcatagtgcaaatgcccctggattgtgac
acacccatcgattcgcaccgaattacggacgccgtttccccggagaaggatgttgacggc
ttgcacacggttaacgaaggtcgcctggccatcggtgaccttggtggtttcctgccctgc
actccttggggttgcctggagttaattcgccgttctggagtagagatcgccggagccagg
gctgtggttctgggacgcagcaagatcgtgggcactcccgccgccgaactgctcaagtgg
gccaatgccacggtcacagtgtgccactcaaagacccgcaacctggaggagatcacccga
agtgcagacattctggtggtcggaattggagtggccgagatggttaagggatcgtggata
aagcccggagcagtggtcatcgattgcggcatcaatgtgaagccagacgccagcaaggcc
agtggcagcaagctggtcggggacgtggactacgcggaagctctccaagtggcaggacat
ttgacgccagtgcccggcggcgtgggacccatgacggtggccatgcttatgaaaaacacc
gtgcgatctgcggcccgattccttgagcgtcttgctaagagccagtgggcccttcaaacg
ctgcccctcaagccccagcgtcccgtgcccagcgatattgtgattgcccgtgcccaaaaa
ccgaaggacattgccgtgctggccaaggagattggtctggaagctcgtgaggtttccttg
tacggaaataagaaggccaagatttcactgtcagtgttggagcgtctgaaggacaaggag
gtgggtcactatgtggttgtagccggtatgacaccaacgcctttgggtgagggtaagacc
accacactaatgggcttggtccaggctctcggcgcgcacaagctgagaaacaccatggct
gctctgcgacagccctcccaaggtccaacctttggcatcaaaggaggagctgctggcggc
ggatacgcccaggtgattcccatggaggagttcaatctccatctgacaggagacattcat
gcggtatcggcagccaataacttgctggccgcccagctggacacccgcatcttccacgag
aatacccaaaaggacaaggccttgtatgacagattggtgcccgcgatcaagggtcagcgg
aaattcagccccattcagctacgccggctccagaaattgggaatcaccaaaaccgatccc
gatacccttaccgctgacgaatacggaccttttgcccggctggacatcgatccggacacg
attatgtgggagcgtgtggtggacatcaacgatcggtacctacgcaccattaccgttggg
caatcgcccactgaaaagggtatttcgagggagacccggttctccatctcggtggccagc
gagatcatggctgtgctagcactatcccgaagtctggaggacatgaagcagcggctggct
gacatggtggtggcattcgacaaacgaggcaagcccgtaaccgctgacgatttgggtgtc
accggtgccctggcagttcttttgaaggacgctctcgagccgaacctgatgcagtcgctc
gagggaactccagtgctggtgcacgctggtccctttgccaacatcgcccacggttgcaac
tcgatcatcgctgatgaagtcggcctaaagctggttggtaaaaatggatttgtctgcacg
gaggccgggttcggatcagatattggcatggaaaagttttgcaacattaagtgtcggaca
tccggtcgcaagccgaacgccatggtgctggtagccactgtgagggccatcaagatgcac
ggcggcggagctcccgtcactcccggagcccccttgaacaagcagtacaccgaggagaac
ttggagctcgtccagaagggtctgcccaatctgctgcagcacatcgagaacggaaaggcc
ttcggcatgccagtggtggtgagccttaatgctcattcagcagacaccccggcggagcat
gagttggtcaaaaaggctgctctggaggcaggtgcattcgccgccgtagtctccactcac
tgggcggacggaggagccggagccgttcagctggccgatgccgtgatcaaggcctgcgaa
cagggcaatcaattccgattgctctacgatctggagctgccgctggtggataagatgaac
aagatcgctacgacgatgtacggcgctggaaaggtggtgctctcgccggcggctgaggag
aaggtcaaacgcctgacggatgcgggttttggcaatctacctatctgcatgtccaaagtc
tccggctccttcaccggcgatgccaaaatcaaaggcgcccccaagggcttcaccctggac
gttgaggacgtatatgtttcagccggagccggctttgtggtcgccatgtgcggtgaggtc
accaaaatgccgggtcttcccacccgcccggcgatctacgatatcgatctgaatacggaa
accggagaaattgagggcctattttag

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