KEGG   Cyclopterus lumpus (lumpfish): 117751685
Entry
117751685         CDS       T09199                                 
Symbol
mthfd1b
Name
(RefSeq) methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1b
  KO
K00288  methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase [EC:1.5.1.5 3.5.4.9 6.3.4.3]
Organism
clum  Cyclopterus lumpus (lumpfish)
Pathway
clum00670  One carbon pool by folate
clum01100  Metabolic pathways
clum01240  Biosynthesis of cofactors
clum04981  Folate transport and metabolism
Module
clum_M00141  C1-unit interconversion, eukaryotes
Brite
KEGG Orthology (KO) [BR:clum00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    117751685 (mthfd1b)
 09150 Organismal Systems
  09154 Digestive system
   04981 Folate transport and metabolism
    117751685 (mthfd1b)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:clum04147]
    117751685 (mthfd1b)
Enzymes [BR:clum01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.5  methylenetetrahydrofolate dehydrogenase (NADP+)
     117751685 (mthfd1b)
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.4  In cyclic amidines
    3.5.4.9  methenyltetrahydrofolate cyclohydrolase
     117751685 (mthfd1b)
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.4  Other carbon-nitrogen ligases
    6.3.4.3  formate---tetrahydrofolate ligase
     117751685 (mthfd1b)
Exosome [BR:clum04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   117751685 (mthfd1b)
SSDB
Motif
Pfam: FTHFS THF_DHG_CYH_C THF_DHG_CYH
Other DBs
NCBI-GeneID: 117751685
NCBI-ProteinID: XP_034419530
Ensembl: ENSCLMG00005012041
LinkDB
Position
22:8990682..9001753
AA seq 934 aa
MSAQIISGKEVSAQVRERLKKDVEQMKLQDPNFRPGLVVLQVGDRDDSNLYISMKLKAAA
EIGINATHMRLPKTATEEEVLHSITEVNENSSVHGLIVQLPLDSVHKIDTEKVTNAVAPE
KDVDGLTSINAGKLSRGDLRDCFIPCTPSGCMELIRQTGVSVAGKRAVVIGRSKIVGAPM
HDLLLWNHATVTTCHSKTADLPGEVSRADILVVGIGKAEMVKGEWIKKGAVVIDCGINHI
PDETKASGKRVVGDVHYASAKELAGFITPVPGGVGPMTVAMLMANTVLSAKRFLESHQPG
KWSISYTKLDLQKPVPSDIVISRSCVPKPIDCLAREVGLLSDEVELFGKTKAKVQLKIIK
RLQAQPDGKYVVVTGITPTPLGEGKSTTTIGLVQALGAHMKLNVFACVRQPSQGPTFGIK
GGAAGGGYSQVIPMEEFNLHLTGDIHAITAANNLVAAAVDARIFHESTQSDKALYNRLVP
LSGGQRKFSPIQINRLKKLGIEKTDPSTLTEEEITRFARLDMDPSSVTWQRVLDTNDRFL
RKITIGQSPTEKGYTREAQFDITVASEIMAVLALTSSLEDMRQRLAKMVVATSRGGQPIT
TEDLGVSGALAVLMKDAIKPNLMQTLEGTPVFVHAGPFANIAHGNSSILADIIALKLVGP
EGFVVTEAGFGADIGMEKFFNIKCRYSGLRPHVVVLVATVRALKMHGGGPTVTAGMPLPK
EYIEENLELLEKGCSNMTKQIENAQHFGLPVVVAVNAFKTDTEAELDLVCNMAKAARAFD
AVRCSHWAEGGAGALALGQAVQRASEAPSKFKFLYDLELPIADKIRIIAQKIYGADDIEL
LPEAQHKVELYTKQGFSKLPICMAKTHLSLSHEADKKGVPTGFIVPIRDIRASVGSGFLF
PLVGTMPTIPGLPTRPCFYDIDLDPETEQVNGLF
NT seq 2805 nt   +upstreamnt  +downstreamnt
atgtcagctcaaatcataagcgggaaagaagtttcagcgcaggtgagggagcgtctaaag
aaggacgtggagcagatgaagctccaggaccctaacttcagacccggtctagtggtttta
caggttggagaccgtgatgattcaaatctgtacatcagcatgaagttgaaggcagcagca
gagattggaataaacgcaacacatatgagacttcccaagactgcaacggaggaggaggtt
cttcacagcatcacagaggtgaatgagaactcgtctgtccacggcctcatcgtgcagctg
cccttggactccgtccataagatcgacacagagaaggtcaccaacgccgtggccccggag
aaggatgtagacggactgaccagcatcaatgcagggaagctgtctcgtggggacctgcgc
gactgcttcatcccatgcacaccaagcggctgcatggagttgatcagacaaaccggtgtg
tctgtggcagggaagagagcggtcgtgattggtcgtagtaagattgtgggagcaccgatg
cacgacctgctgctgtggaaccacgccaccgtcaccacctgccactctaaaaccgcagat
ctccccggagaggtgagccgagcagacatcctggtggttggcatcgggaaagcagagatg
gtgaaaggagagtggatcaagaagggtgcagttgttatcgactgtggcatcaaccacatc
ccagatgagaccaaagcaagtgggaagcgggtggtgggtgatgtccactacgcctcagcc
aaggagctggctggcttcatcacccctgtgcccggtggtgtgggacccatgactgtggcc
atgctgatggcgaacacggtgttgagtgcaaaacgtttcctggagagccaccaaccaggg
aagtggagcatttcttacaccaaactcgaccttcagaagcctgtgccgagcgacattgtg
atttctcgctcctgcgtgccaaagcccatcgactgtctagcaagagaggtgggcctgctg
tctgacgaggtggagctctttggcaaaactaaggccaaggtccagctgaaaatcatcaaa
cgtctgcaggcccagccagatggcaaatatgtggtggtcactggcattacacccaccccc
ttgggtgaaggaaagagcaccaccaccatcggcctggtccaggccctgggagcccacatg
aagctcaatgtgtttgcttgtgtcagacagccttctcagggtcccacctttggcattaaa
ggcggtgctgcaggaggtggatattctcaagtcattccaatggaggagttcaacctccat
ctgactggggacattcacgccatcacggctgccaataacttggtggctgctgccgttgat
gctcgcatcttccacgagtctacacaatctgacaaagctctgtataaccgcttggtccca
ctcagtggaggacagaggaagttctcccccatccagatcaaccgactgaaaaaactgggc
atagaaaagactgatccctccactctgactgaagaagagatcacccgctttgcccgtctg
gacatggacccgagctctgtcacctggcaaagagtgttggacaccaatgatcgtttcctg
aggaagatcacaatcggccagtcgccaactgaaaagggctacacgagagaggcccagttt
gacatcacggtggccagtgaaatcatggcggtgctcgccctcaccagcagcctggaggac
atgcgtcagcgtctggccaagatggtggtggccaccagccgcggcggacagcccatcacc
accgaggacctgggtgtgagtggtgctctagctgtgctaatgaaagatgccatcaagcca
aacctgatgcagaccttggagggaacgcctgtgtttgtccacgccggcccgtttgccaac
atcgcccatggcaactcctccatcctggctgatataatagctttgaaactggttggacct
gagggctttgtggtgacggaggccggctttggtgctgacattggcatggagaagttcttt
aacatcaagtgtcgctactcaggcctgaggccccacgtggtggtgctggtggccactgtt
cgagccctgaagatgcacgggggaggaccaacggtcactgctgggatgccactgccaaag
gaatacatcgaggagaaccttgagctgctggagaagggctgcagcaacatgacgaagcag
atagagaatgcacagcacttcggcttgccagtggtcgtggctgttaatgctttcaagaca
gacactgaggctgagctggacctggtctgcaacatggccaaagccgccagggccttcgac
gccgtgcgctgctcccactgggccgaaggaggagccggtgcattggccctgggccaggct
gtccagagggcctctgaggcccccagcaaattcaagttcctctatgatttggagctccct
attgctgataagattcgaataatcgcccagaagatctacggagcggatgacattgagctt
ctcccagaggctcaacacaaggtggagctctacaccaaacagggtttcagcaagctgcca
atctgcatggcgaagactcacctgtcgctctctcacgaggcggacaagaagggtgtgccc
acagggttcatcgtgccaatcagagacatccgcgccagtgtgggttccggctttttgttc
ccactggttggcacgatgcccacgatccctggtctgcccaccaggccttgtttctatgac
attgacctggaccctgagactgagcaggtcaacggactcttctga

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