KEGG   PATHWAY: ccag00260
Entry
ccag00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Chromohalobacter canadensis
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
ccag00260  Glycine, serine and threonine metabolism
ccag00260

Module
ccag_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:ccag00260]
ccag_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:ccag00260]
ccag_M00033  Ectoine biosynthesis, aspartate => ectoine [PATH:ccag00260]
ccag_M00555  Betaine biosynthesis, choline => betaine [PATH:ccag00260]
ccag_M00621  Glycine cleavage system [PATH:ccag00260]
ccag_M00919  Ectoine degradation, ectoine => aspartate [PATH:ccag00260]
ccag_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:ccag00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Chromohalobacter canadensis [GN:ccag]
Gene
SR908_10650  aspartate kinase [KO:K00928] [EC:2.7.2.4]
SR908_03005  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
SR908_06015  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
SR908_10270  homoserine kinase [KO:K02204] [EC:2.7.1.39]
SR908_06010  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
SR908_11885  low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
SR908_03710  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
SR908_00095  D-2-hydroxyacid dehydrogenase [KO:K00018] [EC:1.1.1.29]
SR908_04595  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
SR908_05760  glycerate kinase [KO:K00865] [EC:2.7.1.165]
SR908_07740  gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
SR908_07505  serA; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
SR908_01740  serC; 3-phosphoserine/phosphohydroxythreonine transaminase [KO:K00831] [EC:2.6.1.52]
SR908_03380  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
SR908_16645  gcvP; aminomethyl-transferring glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
SR908_16660  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
SR908_13760  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
SR908_16650  gcvH; glycine cleavage system protein GcvH [KO:K02437]
SR908_09990  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
SR908_03045  choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
SR908_14920  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
SR908_05210  aldehyde dehydrogenase family protein [KO:K00130] [EC:1.2.1.8]
SR908_14925  betB; betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
SR908_07635  homocysteine S-methyltransferase family protein [KO:K00544] [EC:2.1.1.5]
SR908_12520  aromatic ring-hydroxylating dioxygenase subunit alpha [KO:K00479] [EC:1.14.13.251]
SR908_12525  hybrid-cluster NAD(P)-dependent oxidoreductase [KO:K21832] [EC:1.14.13.251]
SR908_12445  dgcA; dimethylglycine demethylation protein DgcA [KO:K21833] [EC:1.5.7.3]
SR908_12450  (Fe-S)-binding protein [KO:K21834]
SR908_12455  electron transfer flavoprotein subunit alpha/FixB family protein [KO:K25960]
SR908_12460  electron transfer flavoprotein subunit beta [KO:K25961]
SR908_12495  sarcosine oxidase subunit alpha family protein [KO:K00302] [EC:1.5.3.24 1.5.3.1]
SR908_12485  sarcosine oxidase subunit beta family protein [KO:K00303] [EC:1.5.3.24 1.5.3.1]
SR908_12500  soxG; sarcosine oxidase subunit gamma family protein [KO:K00305] [EC:1.5.3.24 1.5.3.1]
SR908_12490  sarcosine oxidase subunit delta [KO:K00304] [EC:1.5.3.24 1.5.3.1]
SR908_12405  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
SR908_04540  eutB; hydroxyectoine utilization dehydratase EutB [KO:K01754] [EC:4.3.1.19]
SR908_06700  threonine/serine dehydratase [KO:K01754] [EC:4.3.1.19]
SR908_08600  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
SR908_07095  aspartate/glutamate racemase family protein [KO:K25316] [EC:5.1.1.10]
SR908_14000  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
SR908_13995  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
SR908_00270  ectB; diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
SR908_00265  ectA; diaminobutyrate acetyltransferase [KO:K06718] [EC:2.3.1.178]
SR908_00275  ectoine synthase [KO:K06720] [EC:4.2.1.108]
SR908_05980  thpD; ectoine hydroxylase [KO:K10674] [EC:1.14.11.55]
SR908_04585  doeA; ectoine hydrolase DoeA [KO:K15783] [EC:3.5.4.44]
SR908_04580  doeB; N(2)-acetyl-L-2,4-diaminobutanoate deacetylase DoeB [KO:K15784] [EC:3.5.1.125]
SR908_04545  aspartate aminotransferase family protein [KO:K15785] [EC:2.6.1.76]
SR908_04550  NAD-dependent succinate-semialdehyde dehydrogenase [KO:K15786] [EC:1.2.1.-]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
ccag00010  Glycolysis / Gluconeogenesis
ccag00020  Citrate cycle (TCA cycle)
ccag00230  Purine metabolism
ccag00250  Alanine, aspartate and glutamate metabolism
ccag00270  Cysteine and methionine metabolism
ccag00290  Valine, leucine and isoleucine biosynthesis
ccag00300  Lysine biosynthesis
ccag00330  Arginine and proline metabolism
ccag00460  Cyanoamino acid metabolism
ccag00470  D-Amino acid metabolism
ccag00564  Glycerophospholipid metabolism
ccag00600  Sphingolipid metabolism
ccag00620  Pyruvate metabolism
ccag00630  Glyoxylate and dicarboxylate metabolism
ccag00640  Propanoate metabolism
ccag00680  Methane metabolism
ccag00860  Porphyrin metabolism
ccag00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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