KEGG   Aptenodytes forsteri (emperor penguin): 103894073
Entry
103894073         CDS       T08527                                 
Symbol
MTHFD1
Name
(RefSeq) C-1-tetrahydrofolate synthase, cytoplasmic
  KO
K00288  methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase [EC:1.5.1.5 3.5.4.9 6.3.4.3]
Organism
afor  Aptenodytes forsteri (emperor penguin)
Pathway
afor00670  One carbon pool by folate
afor01100  Metabolic pathways
afor01240  Biosynthesis of cofactors
afor04981  Folate transport and metabolism
Module
afor_M00141  C1-unit interconversion, eukaryotes
Brite
KEGG Orthology (KO) [BR:afor00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    103894073 (MTHFD1)
 09150 Organismal Systems
  09154 Digestive system
   04981 Folate transport and metabolism
    103894073 (MTHFD1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:afor04147]
    103894073 (MTHFD1)
Enzymes [BR:afor01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.5  methylenetetrahydrofolate dehydrogenase (NADP+)
     103894073 (MTHFD1)
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.4  In cyclic amidines
    3.5.4.9  methenyltetrahydrofolate cyclohydrolase
     103894073 (MTHFD1)
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.4  Other carbon-nitrogen ligases
    6.3.4.3  formate---tetrahydrofolate ligase
     103894073 (MTHFD1)
Exosome [BR:afor04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   103894073 (MTHFD1)
SSDB
Motif
Pfam: FTHFS THF_DHG_CYH_C THF_DHG_CYH DUF6507 OCD_Mu_crystall
Other DBs
NCBI-GeneID: 103894073
NCBI-ProteinID: XP_019326053
LinkDB
Position
Unknown
AA seq 909 aa
MKEKFPGFRPGLAILQVGNRDDSNLYINMKLKAAAEIGISANHIKLPNTATEADVLKCIA
SLNGDPAVHGFIVQLPLDSDKPISTEKITNAVAPEKDVDGLSSINAGKLSRGDLGDCFIP
CTPKGCMELIRQTGIQVAGKRAVVVGRSKIVGAPMHDLLLWNHATVTTCHSKTSTLAEEV
GKADILVVAAGKAEMVKGEWIKPGAIVIDCGINHVPDSTKASGKRVVGDVAYSTAKEKAS
YITPVPGGVGPMTVAMLMQSTVESAQRFLEKFQPGKWNIQYNQLTLKVPVPSDIEISQSC
ILKPIDQVAKEVGLLPDEVELYGQTKAKVHLSALKRLKNQPDGKYIVVTGITPTPLGEGK
STTTVGLVQALGAHLHQNVFACVRQPSQGPTFGIKGGAAGGGYCQVIPMEEFNLHLTGDI
HAITAANNLVAAAVDARIFHELTQTDQALYNRLVPSVNGVRKFSDIQIRRLQKLGINKTD
PTALTKEEVNLFVRLDIDPGTITWQRVLDTNDRFLRKITIGQSPTEKGFSRMAQFDITVS
SEIMAVLALSDGLDDMKKRLGRMVVASSKRGEPVTADDLGVTGALAVLMKDAVKPNLMQT
LEGTPVFVHAGPFANIAHGNSSVLADKIALKLVGKEGFVVTEAGFGADIGMEKFFNIKCR
YSGLRPHVVVLVATVRALKMHGGGPAVTAGVPLPKEYMEENLQLLAKGCSNLNKQIQNAR
MFGVPVVVAVNAFKTDTKAELALVVQLAKEAGAFEAVECTHWAEGGKGAVALAQAVQRAS
QTPSNFRFLYNAELPVIDKIRLIAQQIYGASDIELLPEAQEKVTVYTKQGFGNLPICMAK
THLSLSHDPERKGAPTGFILPIRDIRASVGAGFLYPLVGTMSTMPGLPTRPCFYDIDLDP
VSGEVNGLF
NT seq 2730 nt   +upstreamnt  +downstreamnt
atgaaagagaaatttccaggcttcagaccaggactcgcaattttgcaggttggaaatagg
gatgattcgaacctctacattaatatgaagctgaaggctgctgctgagattgggatcagt
gccaatcacataaaactgccaaacacagcaacagaagctgatgtcctcaagtgcattgcc
tctttgaatggagaccctgctgttcatggctttatagtgcagctgccacttgactctgat
aaacccatcagtacagaaaaaataaccaatgctgttgcacctgagaaggatgtagatggc
ttaagtagcatcaatgctgggaaactctctagaggggaccttggagactgctttattccc
tgtacgccaaaaggatgcatggaacttatcaggcagacaggcatccaggttgcagggaaa
agagctgtagtggttggtcgcagtaagatcgttggtgctcccatgcatgacctgctgctg
tggaatcacgcaacagtaaccacttgccattcaaagacctcaacgctggctgaggaggtt
ggtaaagctgatatcctggtggttgcagctggtaaagctgaaatggtaaaaggtgaatgg
atcaaacctggtgcaattgtaatagactgtggaattaaccatgtgccagacagcacaaag
gccagtggaaaaagagttgtaggagatgtggcgtacagtacagcaaaggaaaaagcttcc
tacatcaccccagttcctggtggcgttgggcctatgactgtggccatgttaatgcagagc
acagtggagagtgcgcagcgttttctggagaagttccagcctggaaaatggaacatccaa
tataaccagcttaccctaaaggtgcctgttccaagtgatattgaaatatcgcagtcttgc
atactcaagcccattgatcaagttgcaaaagaagttggcctgctccctgatgaagtggag
ctctacggccaaactaaagccaaagttcatctgtcagctctgaaacggctgaagaaccag
ccagatggcaaatacattgttgttactgggataactcctactcccctgggagaggggaaa
agcaccactactgttggtcttgttcaagccttaggagcacaccttcaccagaatgtcttt
gcttgtgttcggcagccttctcaggggccaacctttggtataaaaggtggagctgcaggt
ggtggctattgtcaagttatccccatggaagagtttaaccttcacctcaccggtgacatc
catgctatcactgcagccaacaacctggtcgctgctgcagtcgacgcacgtatattccat
gagctaactcagactgaccaggctctctacaaccgtttggtgccttctgtcaatggtgtt
aggaagttctcagacattcagatccgaagactacagaaattgggtattaacaaaactgat
cctacagctttgacaaaggaagaagtaaacttatttgtgagattggacattgacccaggc
accataacatggcaaagagtactggatacaaatgacaggttccttaggaaaatcactatt
ggacagtctccaacagaaaaaggcttctcacgaatggctcagtttgacatcacggtgagc
agtgaaatcatggcagttctagcactctctgatgggttggatgatatgaaaaagcgactg
ggcagaatggtagtagcttctagcaagagaggagaaccagttacagcagatgaccttgga
gtgactggtgctctggctgtcttgatgaaagatgctgttaaaccaaacctcatgcagaca
ctagagggaacaccagtgtttgttcatgctggaccttttgccaatattgcacatgggaat
tcttcagtgttggcagacaaaatagcactgaagcttgtgggtaaagagggatttgttgtt
acagaagcaggatttggtgcagacataggcatggagaaattctttaatattaagtgccgc
tattccggtctccggcctcatgtggtggtgttggttgctactgtccgagctctgaaaatg
catggaggagggcctgcagtcactgctggggtacctttaccaaaggagtacatggaagag
aatcttcaactgttggcaaaaggctgtagtaacctaaacaagcaaatccaaaatgcacgg
atgtttggtgtcccagtagtagtggctgtcaatgctttcaaaacagatacaaaggctgaa
ctggcccttgtagtacaactggcaaaggaagcaggagcatttgaagctgtggagtgcact
cactgggcagagggaggtaaaggagcggttgcactggcccaagctgttcagagagcatcg
cagacacccagcaacttcaggttcctctataatgcggagctccctgttatagacaagatt
agacttattgcacagcagatctatggggcaagtgacattgagctacttccagaagcacag
gagaaagtcaccgtctacactaagcaaggatttggaaacctgccaatctgcatggctaaa
actcacttatcattgtctcatgaccctgaacgaaaaggagcacctacaggttttattctg
ccaatccgagacattcgggccagtgttggtgctggattcctgtatccgctagtaggaacg
atgagcactatgccaggacttcctacaagaccctgtttctatgatatagacttggaccca
gtgtcaggagaagtaaatgggctcttttga

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