KEGG   REACTION: R12659
Entry
R12659                      Reaction                               
Name
tryptamine,NADPH---hemoprotein reductase:oxygen oxidoreductase (5-hydroxylating)
Definition
Tryptamine + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> Serotonin + [Oxidized NADPH---hemoprotein reductase] + H2O
Equation
C00398 + C03024 + C00007 <=> C00780 + C03161 + C00001
Reaction class
RC00490  C00398_C00780
Enzyme
1.14.14.186
Pathway
rn00380  Tryptophan metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00936  Melatonin biosynthesis, plants, tryptophan => serotonin => melatonin
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.186
     R12659  Tryptamine + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> Serotonin + [Oxidized NADPH---hemoprotein reductase] + H2O
Orthology
K24541  tryptamine 5-hydroxylase [EC:1.14.14.186]
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